Results 71 to 80 of about 13,239 (158)
Lysyl oxidase inhibitors attenuate cyclosporin A-induced nephropathy in mouse
Scientific Reports, 2021 Calcineurin inhibitors, such as Cyclosporin (CsA), are the mainstay of anti-rejection therapy in solid organ transplants but can paradoxically induce progressive nephropathy characterised by renal dysfunction and interstitial fibrosis.
Long T. Nguyen +8 more
doaj +1 more source
Replacement of the Catalytic Nucleophile Aspartyl Residue of Dextran Glucosidase by Cysteine Sulfinate Enhances Transglycosylation Activity [PDF]
, 2013 Dextran glucosidase from Streptococcus mutans (SmDG) catalyzes the hydrolysis of an α-1,6-glucosidic linkage at the nonreducing end of isomaltooligosaccharides and dextran.
Kimura, Atsuo +4 more
core +1 more source
Kinetics and stereospecificity of the lysyl oxidase reaction
Journal of Biological Chemistry, 1993 The structural specificity of amine oxidation by lysyl oxidase was investigated using kinetic and NMR spectroscopic analyses. Substrate efficiency increased with increasing molecular distance from the alpha-carbon of the aromatic moiety substituted on the aliphatic chains of a series of primary amines. The p-hydroxyl substituent of p-hydroxybenzylamine
M A, Shah +3 more
openaire +2 more sources
Cell Reports, 2012 Arterial stiffening is a risk factor for cardiovascular disease, but how arteries stay supple is unknown. Here, we show that apolipoprotein E (apoE) and apoE-containing high-density lipoprotein (apoE-HDL) maintain arterial elasticity by suppressing the ...
Devashish Kothapalli +14 more
doaj +1 more source
Investigation of tumor hypoxia using a two-enzyme system for in vitro generation of oxygen deficiency [PDF]
, 2011 Background Oxygen deficiency in tumor tissue is associated with a malign phenotype, characterized by high invasiveness, increased metastatic potential and poor prognosis.
Vasileios Askoxylakis +9 more
core +1 more source
Promising LOX proteins for cartilage-targeting osteoarthritis therapy
Pharmacological ResearchOsteoarthritis (OA) is the most affected joint disease worldwide, touching millions of people every year. It is caused by a progressive degeneration of articular cartilage, causing pain and limited mobility.
Luca Morici +3 more
doaj +1 more source
Frontiers in Oncology, 2020 Glioma is the most prevalent primary brain tumor in adults and has an extremely unfavorable prognosis. As a member of the lysyl oxidase (LOX) family, lysyl-oxidase-like-2 (LOXL2) is known to play different roles in different tumors.
Qing Zhang +5 more
doaj +1 more source
Effect of phenytoin and age on gingival fibroblast enzymes.
Frontiers in Dentistry, 2014 The alteration of cytokine balance is stated to exert greater influence on gingival overgrowth compared to the direct effect of the drug on the regulation of extracellular matrix metabolism.
Surena Vahabi +3 more
doaj
Mechanisms underlying the cardiac antifibrotic effects of losartan metabolites [PDF]
, 2017 Excessive myocardial collagen deposition and cross-linking (CCL), a process regulated by lysyl oxidase (LOX), determines left ventricular (LV) stiffness and dysfunction.
Beaumont, Javier +3 more
core +1 more source
Structure of the Human Lysyl Oxidase Gene
Genomics, 1993 Lysyl oxidase (EC 1.4.3.13), an extracellular copper enzyme, initiates the crosslinking of collagens and elastin by catalyzing oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues. We report here that the human lysyl oxidase gene is about 15 kb in size and consists of seven exons.
E R, Hämäläinen +3 more
openaire +2 more sources