Results 81 to 90 of about 155,219 (227)
Oral wound healing in the elderly: Mechanisms, challenges, and innovations
Periodontology 2000, EarlyView.Abstract Objective This narrative synthesizes current knowledge on the biological mechanisms, clinical challenges, and regenerative innovations for optimizing intraoral wound healing in the elderly. Methods Narrative review of preclinical and clinical studies addressing age‐related changes in the four canonical wound‐healing phases (hemostasis ...
Ann M. Decker +7 more
wiley +1 more source
Lysyl oxidase-like 3 mRNA expression indicates poor survival from oral squamous cell carcinoma
Journal of Dental Sciences, 2011 Background/purpose: Oral squamous cell carcinoma (OSCC) is highly prevalent worldwide. Lysyl oxidase (LOX) is an important enzyme that modulates the extracellular matrix. The LOX superfamily contains LOX and LOX-like (LOXL) enzymes.
Tzong-Ming Shieh +5 more
doaj +1 more source
Understanding exosomes in regenerative dentistry
Periodontology 2000, EarlyView.Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad +2 more
wiley +1 more source
Effect of phenytoin and age on gingival fibroblast enzymes.
Frontiers in Dentistry, 2014 The alteration of cytokine balance is stated to exert greater influence on gingival overgrowth compared to the direct effect of the drug on the regulation of extracellular matrix metabolism.
Surena Vahabi +3 more
doaj
Promising LOX proteins for cartilage-targeting osteoarthritis therapy
Pharmacological ResearchOsteoarthritis (OA) is the most affected joint disease worldwide, touching millions of people every year. It is caused by a progressive degeneration of articular cartilage, causing pain and limited mobility.
Luca Morici +3 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani +5 more
wiley +1 more source
TNF-α post-transcriptionally attenuates Wnt3a-stimulated lysyl oxidase mRNA levels.
, 2014 A) The effect of TNF-α on Wnt3a-stimulated lysyl oxidase mRNA levels in C3H10T1/2 cells was examined by treating cells with Wnt3a- or control-conditioned media in the presence or absence of increasing concentrations of TNF-α.
Philip C. Trackman (329334) +6 more
core +1 more source
Frontiers in Oncology, 2020 Glioma is the most prevalent primary brain tumor in adults and has an extremely unfavorable prognosis. As a member of the lysyl oxidase (LOX) family, lysyl-oxidase-like-2 (LOXL2) is known to play different roles in different tumors.
Qing Zhang +5 more
doaj +1 more source
Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes
The Journal of Physiology, EarlyView.Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone +1 more
wiley +1 more source
Regulation of Lysyl Oxidase by Interferon-γ in Rat Aortic Smooth Muscle Cells
, 2000 —Lysyl oxidase is an essential catalyst for the cross-linking of extracellular collagen and elastin. Abnormalities in lysyl oxidase activity may contribute to the pathogenesis of arterial diseases characterized by abnormal matrix remodeling.
John W. Ford +3 more
core +1 more source