Results 81 to 90 of about 13,239 (158)

Comparing the expression patterns and differences of LOX and LOXL1 during the development of myodural bridge and ligamentum flavum

Frontiers in Cell and Developmental Biology
The ligamentum flavum (LF) is a passive stabilizing tissue that connects two adjacent vertebral arches and contributes to the enclosure the spinal canal, thereby closing the entire canal posteriorly.
Yi-tong Sun, Zhao-ran Li, Hua-xun Lai, Wei Ma, Chan Li, Ji-hang Li, Yan-yan Chi, Sheng-bo Yu, Nan Zheng, Bo Liu, Jian-fei Zhang, Hong-jin Sui   +11 more
doaj   +1 more source

Environmental tobacco smoke exposure exaggerates bleomycin-induced collagen overexpression during pulmonary fibrogenesis

Journal of Inflammation
Environmental tobacco smoke (ETS) is known to cause lung inflammatory and injurious responses. Smoke exposure is associated with the pathobiology related to lung fibrosis, whereas the mechanism that ETS exposure augments pulmonary fibrogenesis is unclear.
Qixin Wang, Chiara Goracci, Isaac Kirubakaran Sundar, Irfan Rahman   +3 more
doaj   +1 more source

Spatial and temporal changes in extracellular elastin and laminin distribution during lung alveolar development [PDF]

, 2018
Lung alveolarization requires precise coordination of cell growth with extracellular matrix (ECM) synthesis and deposition. The role of extracellular matrices in alveogenesis is not fully understood, because prior knowledge is largely extrapolated from ...
Chen, Hui, Fernandez, G. Esteban, Krenitsky, Daria, Li, Nan, Luo, Yongfeng, Mecham, Robert P., Moats, Rex, Pryhuber, Gloria S., Shi, Wei, Warburton, David   +9 more
core   +2 more sources

Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface

Nature Communications, 2017
Lysyl oxidase is able to remodel the extracellular matrix and its expression correlates with poor prognosis. Here the authors show that this protein modulates trapping of the epidermal growth factor receptor at the cell surface, causing persistent ...
HaoRan Tang, Leo Leung, Grazia Saturno, Amaya Viros, Duncan Smith, Gianpiero Di Leva, Eamonn Morrison, Dan Niculescu-Duvaz, Filipa Lopes, Louise Johnson, Nathalie Dhomen, Caroline Springer, Richard Marais   +12 more
doaj   +1 more source

Changes in skeletal collagen crosslinks and matrix hydration in high and low turnover chronic kidney disease [PDF]

, 2014
Chronic kidney disease (CKD) increases fracture risk. The results of this work point to changes in bone collagen and bone hydration as playing a role in bone fragility associated with CKD.
Allen, Matthew R., Chen, Neal, Granke, Mathilde, Moe, Sharon M., Newman, Christopher L., Nyman, Jeffry S.   +5 more
core   +1 more source

Lysyl oxidase inhibitors in colorectal cancer progression

Translational Oncology
The lysine oxidase (LOX) family, consisting of LOX and LOX-like-1–4 (LOXL1–LOXL4), catalyses the cross-linking reaction of collagen and elastin in the extracellular matrix (ECM). Numerous studies have demonstrated that LOX family members are dysregulated
Muxian Liu, Jie Wang, Meihong Liu
doaj   +1 more source

Endogenous mammalian lectin localized extracellularly in lung elastic fibers. [PDF]

, 1984
An affinity-purified antibody preparation raised against a beta-galactoside-binding lectin from bovine lung was used to localize a similar lectin in rat lung by immunofluorescence and by electron microscopy after on-grid staining visualized with ...
Barondes, SH, Cerra, RF, Haywood-Reid, PL   +2 more
core   +3 more sources

Structure of the Mouse Lysyl Oxidase Gene

Genomics, 1993
Lysyl oxidase, an extracellular enzyme involved in the maturation of collagen and elastin, also appears to function as a phenotypic suppressor of transformation by the ras gene product, p21. Genomic clones of the mouse lysyl oxidase gene have been isolated, analyzed, and sequenced.
S, Contente, K, Csiszar, K, Kenyon, R M, Friedman   +3 more
openaire   +2 more sources

The histone deacetylase inhibitor, romidepsin, as a potential treatment for pulmonary fibrosis [PDF]

, 2017
Idiopathic pulmonary fibrosis (IPF) is a progressive disease that usually affects elderly people. It has a poor prognosis and there are limited therapies. Since epigenetic alterations are associated with IPF, histone deacetylase (HDAC) inhibitors offer a
Alzetani, Aiman, Calderwood, Claire J., Conforti, Franco, Davies, Donna E., Davies, Elizabeth R., Ganesan, A., Havelock, Tom, Jones, Mark G., Mahajan, Sumeet, Maher, Toby M., Marshall, Benjamin J., Molyneaux, Philip L., O’reilly, Katherine M.a., Packham, Graham, Richeldi, Luca, Sime, Patricia J., Skipp, Paul J., Smart, David E., Tetley, Teresa D., Thatcher, Thomas H., Thorley, Andrew J., Warner, Jane A.­   +21 more
core   +2 more sources

Lack of association between lysyl oxidase-like 1 polymorphisms and primary open angle glaucoma:a meta-analysis

International Journal of Ophthalmology, 2014
AIM: To study the associations between lysyl oxidase-like 1 (LOXL1) polymorphisms and primary open angle glaucoma (POAG) remain inconsistent. In this study, we have performed a meta-analysis to investigate the association of LOXL1 polymorphisms with POAG
Wen Sun, Yan Sheng, Yu Weng, Chun-Xiao Xu, Susan E.I. Williams, Yu-Tao Liu, Michael A. Hauser, R. Rand Allingham, Ming-Juan Jin, Guang-Di Chen   +9 more
doaj   +1 more source