Results 61 to 70 of about 155,219 (227)

CD8+ T‐cells, CD86+ macrophages and TNF‐α signalling pathways are correlated with fetlock osteoarthritis in racehorses

Equine Veterinary Journal, EarlyView.
Abstract Background There is emerging evidence for the role of the immune system in osteoarthritis (OA) pathophysiology; however, little is known about how immune cells and the synovial transcriptome are altered in naturally occurring equine OA. Objectives To evaluate synovial fluid (SF) and synovial membrane (SM) immune cell populations and the SM ...
E. J. Secor, E. N. Chow, M. Thomas, L. Johnson, A. Siefert, B. Wagner, J. B. Engiles, H. L. Reesink   +7 more
wiley   +1 more source

Proteomic characterization of type I collagen N-terminal crosslinked peptides

Matrix Biology Plus
Collagen cross-links mediated by the lysyl oxidase and lysyl hydroxylase families of enzymes significantly contribute to the biomechanical strength and rigidity of tissues, influencing cell signaling and the downstream cell phenotype.
Zsuzsanna Darula, Maxwell C. McCabe, Alex Barrett, Lauren R. Schmitt, Mark D. Maslanka, Anthony J Saviola, Joseph Orgel, Alma Burlingame, Claudia A. Staab-Weijnitz, Kurt Stenmark, Valerie Weaver, Robert J. Chalkley, Kirk C. Hansen   +12 more
doaj   +1 more source

Bone phenotype of lysyl oxidase isoform knockout mice & in vitro expression of lysyl oxidase proenzyme (II) [PDF]

, 2012
Dissertation (MSD) --Boston University, Goldman School of Dental Medicine, 2012 (Department of Oral Biology).Includes bibliographic references: leaves 71-77.Lysyl oxidases constitute a family of enzymes responsible for the formation of crosslinks in ...
Alsofi, Loai A.
core   +1 more source

Ultra‐Tough Hybrid Supramolecular Gelatin Hydrogels

Small, EarlyView.
Tannic acid‐mediated coacervation compacts gelatin into a dense supramolecular network while generating an acidic microenvironment that activates pre‐embedded bis‐oxazoline crosslinkers. The resulting hybrid hydrogel combines covalent stabilization with reversible energy dissipation, producing high strength, extreme extensibility, substantial toughness,
Patrick Shakari, Christos Leliopoulos, Hamidreza Mokhtari, Rohith Pavan Parvathaneni, Afroditi Kontse, Jöns Hilborn, Oommen P. Varghese   +6 more
wiley   +1 more source

Evaluation of LOXL1 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma [PDF]

, 2008
Purpose: To evaluate genetic susceptibility of lysyl oxidase-like 1 (LOXL1) gene polymorphisms to exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) in a case-control cohort of American and European patients.
Spiteri, Anthony, Tarkkanen, A, Sarfarazi, M, O\u27Brien, Colm, Ritch, Robert, Tarkkanen, Ahti, Child, AH, Aragon-Martin, JA, Spiteri, A, Liebmann, Jeffrey, Liebmann, J, Cobb, CJ, Blaaow, Karima, Mercieca, Franco, Mercieca, F, Damji, KF, O'Brien, C, Blaaow, K, Rezaie, T, Cobb, Caroline J, Damji, Karim F, Ritch, R, Aragon-Martin, Jose A   +22 more
core   +2 more sources

Four‐dimensional immuno‐mechanobiomaterials: Dynamic material cues that program host response to prevent fibrosis and enable regeneration

VIEW, EarlyView.
Dynamic immuno‐mechanobiomaterials with time‐programmed mechanical adaptation orchestrate host responses through precise mechanotransduction and immune‐stromal regulation. These adaptive biomaterials minimize mechanical mismatch, attenuate the forign dy response and fibrosis, promote angiogenesis and controlled extracellular matrix remodeling, and ...
Gobinath Vellapalayam Manoharan, Kathirvel Ayyaswamy, Parthasarathy Vellaichamy, Nagarajan Deivanayagam Pillai, Rithik Gobinath   +4 more
wiley   +1 more source

LOXL2 catalytically inactive mutants mediate epithelial-to-mesenchymal transition

Biology Open, 2014
Summary Lysyl-oxidase-like 2 (LOXL2) is a member of the lysyl oxidase family that catalyzes the cross-linking of collagens or elastins in the extracellular matrix, thus regulating the tensile strength of tissues.
Eva P. Cuevas, Gema Moreno-Bueno, Giacomo Canesin, Vanesa Santos, Francisco Portillo, Amparo Cano   +5 more
doaj   +1 more source

From patient to tumor organoid: Culture protocol choice controls glioblastoma tumor architecture and identity

Brain Pathology, EarlyView.
How glioblastoma organoids are made shapes what they become. Fragment‐based cultures preserve extracellular matrix networks, cellular diversity, and primary tumor identity, whereas dissociation‐based cultures shift toward growth‐adapted states and simplified microenvironments. Abstract Patient‐derived tumor organoids are widely used in cancer research,
Jana Slovackova, Ondrej Bernatik, Katarina Cimborova, Martin Barak, Michal Hendrych, Karolina Kocourkova, Marie Sulcova, Jaroslav Olha, Katerina Amruz Cerna, Zdenek Hodny, Radim Jancalek, Dasa Bohaciakova   +11 more
wiley   +1 more source

Optical molecular imaging of lysyl oxidase activity – detection of active fibrogenesis in human lung tissue [PDF]

, 2015
Aberrant fibrogenesis is a feature of many diseases in multiple organ systems. The lysyl oxidase family of enzymes are central to tissue homeostasis and elevated lysyl oxidase activity is implicated in fibroproliferation as well as in cancer stroma.
Miele, Amy, Hirani, Nik, Chankeshwara, Sunay V., Michels, Chesney, Aslam, Tashfeen, Akram, Ahsan R.; id_orcid, Dhaliwal, Kevin, Haslett, Chris, Bradley, Mark, Akram, Ahsan R., McDonald, Neil, Chankeshwara, Sunay V, Megia Fernandez, Alicia   +12 more
core   +1 more source

In silico molecular docking and molecular dynamics simulation studies of potential inhibitors of canine lysyl oxidase

Heliyon
Lysyl oxidase (LOX), an extracellular copper-dependent oxidising enzyme, carries out oxidation of peptidyl lysine resulting in covalent cross-linkage and stabilisation of elastin and collagen fibres.
Afnan Saleem, Irfan Gul, Amreena Hassan, Jan Mohd Muneeb, Mahak Khan, Abrar Ahad Malik, B.V. Sunil Kumar, Satparkash Singh   +7 more
doaj   +1 more source