Results 61 to 70 of about 13,239 (158)

Effect of Estrogen on Musculoskeletal Performance and Injury Risk. [PDF]

, 2018
Estrogen has a dramatic effect on musculoskeletal function. Beyond the known relationship between estrogen and bone, it directly affects the structure and function of other musculoskeletal tissues such as muscle, tendon, and ligament.
Baar, Keith, Chidi-Ogbolu, Nkechinyere
core  

Vascular lysyl oxidase over-expression alters extracellular matrix structure and induces oxidative stress [PDF]

, 2018
Lysyl oxidase (LOX) participates in the assembly of collagen and elastin fibres. The impact of vascular LOX over-expression on extracellular matrix (ECM) structure and its contribution to oxidative stress has been analysed. Methods Studies were conducted
Briones, Ana M., García-Redondo, Ana B., Martínez-González, Jose, Rodríguez, Cristina, Salaíces, Mercedes, Varona, Saray   +5 more
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In silico molecular docking and molecular dynamics simulation studies of potential inhibitors of canine lysyl oxidase

Heliyon
Lysyl oxidase (LOX), an extracellular copper-dependent oxidising enzyme, carries out oxidation of peptidyl lysine resulting in covalent cross-linkage and stabilisation of elastin and collagen fibres.
Afnan Saleem, Irfan Gul, Amreena Hassan, Jan Mohd Muneeb, Mahak Khan, Abrar Ahad Malik, B.V. Sunil Kumar, Satparkash Singh   +7 more
doaj   +1 more source

Common polymorphisms in human lysyl oxidase genes are not associated with the adolescent idiopathic scoliosis phenotype

BMC Medical Genetics, 2011
Background Although adolescent idiopathic scoliosis affects approximately 3% of adolescents, the genetic contributions have proven difficult to identify.
Wise Carol A, Dobbs Matthew B, Gurnett Christina A, McGregor Tracy L, Morcuende Jose A, Morgan Thomas M, Menon Ramkumar, Muglia Louis J   +7 more
doaj   +1 more source

Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer

Nature Communications, 2020
The development of chemoresistance is a major hurdle in triple negative breast cancer (TNBC). Here, the authors show that lysyl oxidase (LOX) is overexpressed in chemoresistant TNBCs, and when inhibited reduces collagen cross-linking, fibronectin fibril ...
Ozge Saatci, Aysegul Kaymak, Umar Raza, Pelin G. Ersan, Ozge Akbulut, Carolyn E. Banister, Vitali Sikirzhytski, Unal Metin Tokat, Gamze Aykut, Suhail A. Ansari, Hayriye Tatli Dogan, Mehmet Dogan, Pouria Jandaghi, Aynur Isik, Fatma Gundogdu, Kemal Kosemehmetoglu, Omer Dizdar, Sercan Aksoy, Aytekin Akyol, Aysegul Uner, Phillip J. Buckhaults, Yasser Riazalhosseini, Ozgur Sahin   +22 more
doaj   +1 more source

Lysyl Oxidase (LOX): Functional Contributions to Signaling Pathways

Biomolecules, 2020
Cu-dependent lysyl oxidase (LOX) plays a catalytic activity-related, primary role in the assembly of the extracellular matrix (ECM), a dynamic structural and regulatory framework which is essential for cell fate, differentiation and communication during ...
Rozalia Laczko, Katalin Csiszar
doaj   +1 more source

Characterization of the Native Lysine Tyrosylquinone Cofactor in Lysyl Oxidase by Raman Spectroscopy [PDF]

, 1997
Lysine tyrosylquinone (LTQ) recently has been identified as the active site cofactor in lysyl oxidase by isolation and characterization of a derivatized active site peptide.
Klinman, Judith P., Mure, Minae, Nakamura, Nobuhumi, Sanders-Loehr, Joann, Wang, Sophie X.   +4 more
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The Role of Lysine Tyrosylquinone Containing Oxidases in Progression of Solid Tumors

Frontiers in Bioscience-Landmark
Lysine tyrosylquinone (LTQ), the cofactor formed through copper-assisted tyrosine oxidation and subsequent intramolecular cross-linking, is inherent in all members of the lysyl oxidase family.
Tatyana V. Korneenko, Nikolay B. Pestov, Nickolai A. Barlev   +2 more
doaj   +1 more source

Lysyl oxidase-like 3 mRNA expression indicates poor survival from oral squamous cell carcinoma

Journal of Dental Sciences, 2011
Background/purpose: Oral squamous cell carcinoma (OSCC) is highly prevalent worldwide. Lysyl oxidase (LOX) is an important enzyme that modulates the extracellular matrix. The LOX superfamily contains LOX and LOX-like (LOXL) enzymes.
Tzong-Ming Shieh, Shun-Yao Ko, Shu-Shin Chang, Kuo-Wei Chang, Yin-Hua Shih, Chung-Ji Liu   +5 more
doaj   +1 more source

The promoter from SlREO, a highly-expressed, root-specific Solanum lycopersicum gene, directs expression to cortex of mature roots [PDF]

, 2008
Root-specific promoters are valuable tools for targeting transgene expression, but many of those already described have limitations to their general applicability.
Abe, Andrew J. Thompson, Bassett, Benfey, Bird, Bradford, Bucher, Bucher, Butler, Cardon, Carole Wright, Chan, Chen, Diatchenko, Elmayan, Fester, Garoosi, Giritch, Giritch, Gittins, Grichko, Gubler, Hagen, Hans, Hausinger, Hertig, Higo, Hudson, Ian B. Taylor, Itzhaki, Jefferson, John Andrews, Karimi, Keller, Kenneth Manning, Klinedinst, Koyama, Krasnyanski, K�ck, Liang, Liedl, L�on-Kloosterziel, Marin, Matsuda, Matthew O. Jones, Mudge, Mudge, Okubara, Phillips, Prescott, Prescott, Radi, Ro, Saslowsky, Sobeih, Subramanian, Suzuki, Tang, Thompson, Tirajoh, Vaughan, von Schweinichen, White, Xiao, Xu, Yamamoto, Yoshimoto, Zhang, Zhang   +68 more
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