Results 41 to 50 of about 155,219 (227)

Immunological characterization of bovine lysyl oxidase

, 1985
1. 1. Antibodies to homogeneously purified bovine aortic lysyl oxidase were prepared in chickens. 2. 2. The chicken anti-lysyl oxidase antiserum effectively inhibited bovine aortic lysyl oxidase activity.
Chichester, C. O., Burbelo, P. D., Kagan, M.   +2 more
core   +1 more source

Lysyl oxidase-like 3 restrains mitochondrial ferroptosis to promote liver cancer chemoresistance by stabilizing dihydroorotate dehydrogenase

Nature Communications, 2023
To overcome chemotherapy resistance, novel strategies sensitizing cancer cells to chemotherapy are required. Here, we screen the lysyl-oxidase (LOX) family to clarify its contribution to chemotherapy resistance in liver cancer.
Meixiao Zhan, Yufeng Ding, Shanzhou Huang, Yuhang Liu, Jing Xiao, Hua Yu, Ligong Lu, Xiongjun Wang   +7 more
doaj   +1 more source

LOXL2 Inhibitors and Breast Cancer Progression

Antioxidants, 2021
LOX (lysyl oxidase) and lysyl oxidase like-1–4 (LOXL 1–4) are amine oxidases, which catalyze cross-linking reactions of elastin and collagen in the connective tissue.
Sandra Ferreira, Nuno Saraiva, Patrícia Rijo, Ana S. Fernandes   +3 more
doaj   +1 more source

Characterization of Recombinant Lysyl Oxidase Propeptide

, 2016
Lysyl oxidase enzyme activity is critical for the biosynthesis of mature and functional collagens and elastin. In addition, lysyl oxidase has tumor suppressor activity that has been shown to depend on the propeptide region (LOX-PP) derived from pro-lysyl
Philip C. Trackman (329334), Erdjan Salih (2234080), Emile D. Vu (2307778), Kathrin H. Kirsch (329335), Siddharth R. Vora (2307781), Ying Guo (53523), Danielle N. Stephens (333483), Gail E. Sonenshein (329336)   +7 more
core   +2 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Lysyl oxidase-like 2 promoter hypermethylation in mid-dermal elastolysis

, 2016
Lysyl oxidase-like 2 promoter hypermethylation in mid-dermal ...
GIROLOMONI, Giampiero, Gambichler, T, Reininghaus, L, Schulze, Hj, Skrygan, M, Schaller, J, Colato, C, Hessam, S, Heitzer, E.   +8 more
core   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Primers for Site-directed Mutagenesis of the Lysyl Oxidase Promoter.

, 2014
Primers for Site-directed Mutagenesis of the Lysyl Oxidase Promoter.
Philip C. Trackman (329334), Katharine L. Sodek (590061), Debashree Saxena (590063), Wan-Peng Xu (590062), Michael Faibish (590064), Roozbeh Khosravi (590060), Manish V. Bais (333481)   +6 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Lysyl oxidase in the pathology of the heart

Acta Biomedica Scientifica
Cardiovascular pathology is currently one of the main causes of disability and mortality of the able-bodied population. Fibrosis, an overgrowth of connective tissue, occupies one of the main places among the diseases of this pathology.
N. N. Dremina, I. S. Trukhan, I. A. Shurygina, M. G. Shurygin   +3 more
doaj   +1 more source