Results 41 to 50 of about 13,239 (158)

Purification procedure and assay for the activity of lysyl oxidase

The Ukrainian Biochemical Journal, 2018
The goal of the present study was to extract and purify lysyl oxidase from rodent’s tissues by a fast, simple, effective and inexpensive method and to develop a sensitive, time-saving lysyl oxidase specific activity assay for routine in vitro experiments.
.O. O. Gudkova, N. V. Latyshko, O. V. Zaitseva, S. G. Shandrenko   +3 more
doaj   +1 more source

Neural regulation of cancer: from mechanobiology to inflammation. [PDF]

, 2016
Despite recent progress in cancer research, the exact nature of malignant transformation and its progression is still not fully understood. Particularly metastasis, which accounts for most cancer death, is a very complex process, and new treatment ...
Kim, Tae-Hyung, Rowat, Amy C, Sloan, Erica K   +2 more
core   +2 more sources

α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site. [PDF]

, 2017
Tumors are fibrotic and characterized by abundant, remodeled, and cross-linked collagen that stiffens the extracellular matrix stroma. The stiffened collagenous stroma fosters malignant transformation of the tissue by increasing tumor cell tension to ...
Cassereau, L, García, AJ, Gooch, KJ, Hannachi, E-I, Miroshnikova, YA, Mouw, JK, Ou, G, Pickup, M, Rozenberg, GI, Sarang-Sieminski, AL, Templeman, KL, Weaver, VM   +11 more
core   +2 more sources

Regulation of lysyl oxidase in vascular cells: lysyl oxidase as a new player in cardiovascular diseases [PDF]

Cardiovascular Research, 2008
Lysyl oxidase (LOX) plays a crucial role in the maintenance of extracellular matrix stability and could participate in vascular remodelling associated with cardiovascular diseases. Evidence from in vitro and in vivo studies shows that LOX downregulation is associated with the endothelial dysfunction characteristic of earlier stages of the ...
Tejedor-Rodríguez, Cristina, Martínez-González, José, Raposo, Berta, Alcudia, Javier F., Guadall, Anna, Badimón Maestro, Lina   +5 more
openaire   +3 more sources

In vivo manipulation of the extracellular matrix induces vascular regression in a basal chordate. [PDF]

, 2017
We investigated the physical role of the extracellular matrix (ECM) in vascular homeostasis in the basal chordate Botryllus schlosseri, which has a large, transparent, extracorporeal vascular network encompassing an area >100 cm2 We found that the ...
Boyer, Scott W, Braden, Brian P, Calhoun, Chris, De Tomaso, Anthony W, Langenbacher, Adam, Maio, Alessandro Di, Rodriguez, Delany, Setar, Leah, Taketa, Daryl A, Valentine, Megan T   +9 more
core   +1 more source

Propagation-based phase-contrast synchrotron imaging of aortic dissection in mice : from individual elastic lamella to 3D analysis [PDF]

, 2018
In order to show the advantage and potential of propagation-based phase-contrast synchrotron imaging in vascular pathology research, we analyzed aortic medial ruptures in BAPN/AngII-infused mice, a mouse model for aortic dissection. Ascending and thoraco-
Aoki, Hiroki, Aslanidou, Lydia, De Backer, Julie, Logghe, Gerlinde, Segers, Patrick, Stampanoni, Marco, Stergiopulos, Nikolaos, Trachet, Bram, Villaneuva-Perez, Pablo   +8 more
core   +3 more sources

Characterization of Recombinant Lysyl Oxidase Propeptide [PDF]

Biochemistry, 2010
Lysyl oxidase enzyme activity is critical for the biosynthesis of mature and functional collagens and elastin. In addition, lysyl oxidase has tumor suppressor activity that has been shown to depend on the propeptide region (LOX-PP) derived from pro-lysyl oxidase (Pro-LOX) and not on lysyl oxidase enzyme activity.
Siddharth R, Vora, Ying, Guo, Danielle N, Stephens, Erdjan, Salih, Emile D, Vu, Kathrin H, Kirsch, Gail E, Sonenshein, Philip C, Trackman   +7 more
openaire   +2 more sources

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy [PDF]

, 2015
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer‐related mortality. Despite significant advances made in the treatment of other cancers, current chemotherapies offer little survival benefit in this disease ...
Amy Au, Andrew Biankin, Bryan W Miller, Caroline Springer, Christopher Ross Carter, Colin McKay, Colin Steele, David Chang, Emma Shanks, Ewan McGhee, Grazia Saturno, Janine T Erler, Jennifer P Morton, Joshua Leach, Karin Oien, Kurt Anderson, Lynn McGarry, Mark Pinese, Nigel B Jamieson, Owen J Sansom, Paul Timpson, Peter Bailey, Richard Marais, Saadia Karim, Thomas R Jeffry Evans, Timpson P   +25 more
core   +2 more sources

The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase [PDF]

, 2015
Tumour metastasis is a complex process involving reciprocal interplay between cancer cells and host stroma at both primary and secondary sites, and is strongly influenced by microenvironmental factors such as hypoxia.
A Agrawal, A Bondareva, A Gartland, AC Monteiro, Alison Gartland, AM Baker, AM Baker, AM Parfitt, Anette M. Høye, Ankita Agrawal, BE Bax, CP El-Haibi, DA Chan, Demelza Bird, EJ Feres-Filho, Erwin M. Schoof, Georgina Lang, Hamish Forrest, HE Barker, Holly R. Evans, Iain D. Huggins, IR Garrett, Janine T. Erler, JT Chi, JT Erler, JT Erler, L Jin, Lara Perryman, M Smid, MA Blanco, MJ van de Vijver, N Pischon, N Wang, Norain Ab Latif, PS Steeg, RE Coleman, RN Kaplan, Robin M. H. Rumney, Rune Linding, S Hiratsuka, SR Vora, Thomas R. Cox, TR Cox, WJ Boyle, Y Kang   +44 more
core   +2 more sources

Lysyl oxidase in the pathology of the heart

Acta Biomedica Scientifica
Cardiovascular pathology is currently one of the main causes of disability and mortality of the able-bodied population. Fibrosis, an overgrowth of connective tissue, occupies one of the main places among the diseases of this pathology.
N. N. Dremina, I. S. Trukhan, I. A. Shurygina, M. G. Shurygin   +3 more
doaj   +1 more source