Results 21 to 30 of about 13,239 (158)
A narrative review on serum biomarkers of cardiac fibrosis
Journal of the Practice of Cardiovascular Sciences, 2023 Myocardial fibrosis is the excessive deposition of extracellular matrix (ECM) proteins in the cardiac interstitium leading to pathological conditions of the heart.
Santoshi Kumari +3 more
doaj +1 more source
Molecular Insights Into Lysyl Oxidases in Cartilage Regeneration and Rejuvenation
Frontiers in Bioengineering and Biotechnology, 2020 Articular cartilage remains among the most difficult tissues to regenerate due to its poor self-repair capacity. The lysyl oxidase family (LOX; also termed as protein-lysine 6-oxidase), mainly consists of lysyl oxidase (LO) and lysyl oxidase-like 1-4 ...
Weiping Lin +3 more
doaj +1 more source
Targeting lysyl oxidase reduces peritoneal fibrosis. [PDF]
PLoS ONE, 2017 Abdominal surgery and disease cause persistent abdominal adhesions, pelvic pain, infertility and occasionally, bowel obstruction. Current treatments are ineffective and the aetiology is unclear, although excessive collagen deposition is a consistent ...
Christopher R Harlow +12 more
doaj +1 more source
Dill extract induces elastic fiber neosynthesis and functional improvement in the ascending aorta of aged mice with reversal of age-dependent cardiac hypertrophy and involvement of lysyl oxidase-like-1 [PDF]
, 2020 Elastic fibers (90% elastin, 10% fibrillin-rich microfibrils) are synthesized only in early life and adolescence mainly by the vascular smooth muscle cells through the cross-linking of its soluble precursor, tropoelastin.
Boyle, Walter A +7 more
core +3 more sources
Lysyl Oxidases in the Trabecular Meshwork [PDF]
Journal of Glaucoma, 2014 The mechanical properties of the extracellular matrix (ECM) play an important role in maintaining cellular function and overall tissue homeostasis. Emerging evidence suggests that biomechanical modifications of the ECM may be initiators and/or drivers of disease, exemplified by increased tissue stiffness.
Robert J, Wordinger, Abbot F, Clark
openaire +2 more sources
Lysyl Oxidase and the Tumor Microenvironment [PDF]
International Journal of Molecular Sciences, 2016 The lysyl oxidase (LOX) family of oxidases contains a group of extracellular copper-dependent enzymes that catalyze the cross-linking of collagen and elastin by oxidation, thus maintaining the rigidity and structural stability of the extracellular matrix (ECM).
Tong-Hong Wang +2 more
openaire +2 more sources
Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces [PDF]
, 2015 The diverse composition and structure of extracellular matrix (ECM) interfaces encountered by tumor cells at secondary tissue sites can influence metastatic progression. Extensive in vitro and in vivo data has confirmed that metastasizing tumor cells can
Caley, Matthew P. +7 more
core +2 more sources
Biomedicines, 2022 Lysyl oxidase (LOX) is a secretory protein that catalyzes elastin and collagen cross-linking. Lowering LOX expression and activity in endothelial cells is associated with a high risk of aneurysms and vascular malformation.
Rolf Schreckenberg +9 more
doaj +1 more source
Incorporation of copper into lysyl oxidase [PDF]
Biochemical Journal, 1997 Lysyl oxidase is a copper-dependent enzyme involved in extracellular processing of collagens and elastin. Although it is known that copper is essential for the functional activity of the enzyme, there is little information on the incorporation of copper. In the present study we examined the insertion of copper into lysyl oxidase using 67Cu in cell-free
T, Kosonen +4 more
openaire +2 more sources
Comparing hydrazine-derived reactive groups as inhibitors of quinone-dependent amine oxidases
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017 Lysyl oxidase has emerged as an important enzyme in cancer metastasis. Its activity has been reported to become upregulated in several types of cancer, and blocking its activity has been shown to limit the metastatic potential of various cancers.
Ashley A. Burke +5 more
doaj +1 more source