Results 1 to 10 of about 155,219 (227)

Lysyl Oxidase Like-4 (LOXL4) as a tumor marker and prognosticator in advanced stage laryngeal cancer

Brazilian Journal of Otorhinolaryngology, 2022
Introduction: Lysyl oxidase-like 4 is an amine oxidase from the lysyl oxidase family that was previously shown to be overexpressed in head and neck cancer and upregulated in response to hypoxia. The possible role of lysyl oxidase-like 4 as a tumor marker
Ozan Muzaffer Altuntaş, Nilda Süslü, Yeşim Gaye Güler Tezel, Hayriye Tatlı Doğan, Taner Yılmaz   +4 more
doaj   +3 more sources

Expression of Lysyl Oxidase-Related Protein and Effect of Lysyl Oxidase Inhibition in Cyclosporine-Induced Nephropathy Mouse Model [PDF]

Pharmaceuticals
Background/Objectives Lysyl oxidase-like 2 (LOXL2), a member of the lysyl oxidase family of amine oxidases involved in collagen cross-linking, has emerged as a key mediator of pathological extracellular matrix remodeling and tissue fibrosis. Dysregulated
Hyo Jeong Kim, Tae Yeon Kim, Jong Hyun Jhee, Hoon Young Choi, Jae Myun Lee, Hyeong Cheon Park   +5 more
doaj   +2 more sources

A novel function for lysyl oxidase in pluripotent mesenchymal cell proliferation and relevance to inflammation-associated osteopenia. [PDF]

PLoS ONE, 2014
Lysyl oxidase is a multifunctional enzyme required for collagen biosynthesis. Various growth factors regulate lysyl oxidase during osteoblast differentiation, subject to modulation by cytokines such as TNF-α in inflammatory osteopenic disorders including
Roozbeh Khosravi, Katharine L Sodek, Wan-Peng Xu, Manish V Bais, Debashree Saxena, Michael Faibish, Philip C Trackman   +6 more
doaj   +2 more sources

Lysyl oxidase inhibitors in colorectal cancer progression [PDF]

Translational Oncology
The lysine oxidase (LOX) family, consisting of LOX and LOX-like-1–4 (LOXL1–LOXL4), catalyses the cross-linking reaction of collagen and elastin in the extracellular matrix (ECM). Numerous studies have demonstrated that LOX family members are dysregulated
Muxian Liu, Jie Wang, Meihong Liu
doaj   +2 more sources

Hydrogen sulfide generated by cystathionine gamma lyase inhibits lysyl oxidase and protects against calcific tendinopathy [PDF]

Journal of Orthopaedic Translation
Background/objective: Increased lysyl oxidase (LOX) activity favors pathologic cartilage and vessel calcification. LOX promotes disease through enhanced collagen cross-linking, inflammation, reactive oxygen species (ROS) production, cell trans ...
Elodie Faure, Ilaria Bernabei, Driss Ehirchiou, Philipp Michel, Daniel Kronenberg, Thomas Pap, Giuseppe Cirino, Richard Stange, Nathalie Busso, Sonia Nasi   +9 more
doaj   +2 more sources

Induced collagen cross-links enhance cartilage integration. [PDF]

PLoS ONE, 2013
Articular cartilage does not integrate due primarily to a scarcity of cross-links and viable cells at the interface. The objective of this study was to test the hypothesis that lysyl-oxidase, a metalloenzyme that forms collagen cross-links, would be ...
Aristos A Athens, Eleftherios A Makris, Jerry C Hu   +2 more
doaj   +1 more source

Relationship between plasma cell-free DNA changes and lysyl oxidase during the treatment and prognosis of canine transmissible venereal tumors

BMC Veterinary Research, 2022
Background Transmissible venereal tumors (TVT) are a wide range of canine tumors for which there are no effective markers to monitor the therapeutic response in real-time.
Mona Mohamadzaheri, Hadi Cheraghi, Darioush Shirani, Ali Hatamkhani   +3 more
doaj   +1 more source

Insights from the in silico structural, functional and phylogenetic characterization of canine lysyl oxidase protein

Journal of Genetic Engineering and Biotechnology, 2020
Background Lysyl oxidase is an extracellular regulatory enzyme with an imperative role in interlinking of collagen and elastin by oxidizing lysine residues. Lysyl oxidase has been implicated in incidence of mammary tumors in bitches.
Afnan Saleem, Shiveeli Rajput
doaj   +1 more source

Arterial stiffness and cardiac dysfunction in Hutchinson–Gilford Progeria Syndrome corrected by inhibition of lysyl oxidase

Life Science Alliance, 2021
The findings show that increased lysyl oxidase abundance is causal for the elevated arterial stiffness present in the arteries of Hutchinson–Gilford Progeria Syndrome mice.
Ryan von Kleeck, Emilia Roberts, Paola Castagnino, Kyle Bruun, Sonja A Brankovic, Elizabeth A Hawthorne, Tina Xu, John W Tobias, Richard K Assoian   +8 more
doaj   +1 more source

Properties of a cryptic lysyl oxidase from haloarchaeon Haloterrigena turkmenica [PDF]

PeerJ, 2019
Background Lysyl oxidases (LOX) have been extensively studied in mammals, whereas properties and functions of recently found homologues in prokaryotic genomes remain enigmatic. Methods LOX open reading frame was cloned from Haloterrigena turkmenica in an
Nikolay B. Pestov, Daniel V. Kalinovsky, Tatyana D. Larionova, Alia Z. Zakirova, Nikolai N. Modyanov, Irina A. Okkelman, Tatyana V. Korneenko   +6 more
doaj   +2 more sources