Results 31 to 40 of about 155,219 (227)
Targeting lysyl oxidase reduces peritoneal fibrosis. [PDF]
PLoS ONE, 2017 Abdominal surgery and disease cause persistent abdominal adhesions, pelvic pain, infertility and occasionally, bowel obstruction. Current treatments are ineffective and the aetiology is unclear, although excessive collagen deposition is a consistent ...
Christopher R Harlow +12 more
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Lysyl Oxidase and the Tumor Microenvironment [PDF]
International Journal of Molecular Sciences, 2016 The lysyl oxidase (LOX) family of oxidases contains a group of extracellular copper-dependent enzymes that catalyze the cross-linking of collagen and elastin by oxidation, thus maintaining the rigidity and structural stability of the extracellular matrix (ECM).
Tong-Hong Wang +2 more
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Comparing hydrazine-derived reactive groups as inhibitors of quinone-dependent amine oxidases
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017 Lysyl oxidase has emerged as an important enzyme in cancer metastasis. Its activity has been reported to become upregulated in several types of cancer, and blocking its activity has been shown to limit the metastatic potential of various cancers.
Ashley A. Burke +5 more
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Frontiers in Chemistry, 2018 Accumulating evidence suggests an unequivocal role of lysyl oxidases as key players of tumor progression and metastasis, which renders this enzyme family highly attractive for targeted non-invasive functional imaging of tumors. Considering their function
Manuela Kuchar +15 more
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Site-specific expression of amine oxidases in breast cancer metastases
Tumor Biology, 2018 We aimed to evaluate the expression of amine oxidase-related proteins in metastatic breast cancer tissue and determine its clinical implication. A tissue microarray was constructed from a total of 126 metastatic breast tumors (31 bone metastases (24.6%),
Yoon Jin Cha, Woo Hee Jung, Ja Seung Koo
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Ibn Al-Haitham Journal for Pure and Applied Sciences, 2018 This study was aimed to determine bone formation markers (OST and BALP) and lysyl oxidase in diabetes and non-diabetes Iraqi acromegaly patients in addition to find the relationship among these parameters.
Eiman A. Abass +2 more
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Biomedicines, 2022 Lysyl oxidase (LOX) is a secretory protein that catalyzes elastin and collagen cross-linking. Lowering LOX expression and activity in endothelial cells is associated with a high risk of aneurysms and vascular malformation.
Rolf Schreckenberg +9 more
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PLoS ONE, 2023 The purpose of this study was to determine whether FABP1 and FAS regulate expression of collagen and its crosslinking via lysyl oxidase in isolated adipocytes from Zongdihua pigs.
Rong Yang +8 more
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Incorporation of copper into lysyl oxidase [PDF]
Biochemical Journal, 1997 Lysyl oxidase is a copper-dependent enzyme involved in extracellular processing of collagens and elastin. Although it is known that copper is essential for the functional activity of the enzyme, there is little information on the incorporation of copper. In the present study we examined the insertion of copper into lysyl oxidase using 67Cu in cell-free
T, Kosonen +4 more
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The Turkish Journal of Gastroenterology, 2022 Objectives: This study aims to investigate the association of serum lysyl oxidase (LOX) levels with systemic sclerosis (SSc), to examine the relationship between LOX and disease onset, and to evaluate the probable effects of hyperlipidemia on the ...
Mohammad Hassan Jokar +5 more
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