Results 11 to 20 of about 155,219 (227)
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on LOX (lysyl oxidase), with data on DNA, on the protein encoded, and where the gene is implicated.
Fong, SFT, Fong, KSK, Csiszar, K
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Purification procedure and assay for the activity of lysyl oxidase
The Ukrainian Biochemical Journal, 2018 The goal of the present study was to extract and purify lysyl oxidase from rodent’s tissues by a fast, simple, effective and inexpensive method and to develop a sensitive, time-saving lysyl oxidase specific activity assay for routine in vitro experiments.
.O. O. Gudkova +3 more
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Lysyl oxidase in colorectal cancer
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2013 Colorectal cancer is the third most prevalent form of cancer worldwide and fourth-leading cause of cancer-related mortality, leading to ∼600,000 deaths annually, predominantly affecting the developed world. Lysyl oxidase is a secreted, extracellular matrix-modifying enzyme previously suggested to act as a tumor suppressor in colorectal cancer. However,
Cox, Thomas R, Erler, Janine T
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Lysyl Oxidase in Cancer Research
Future Oncology, 2014 Metastasis is the main reason for cancer-associated deaths and therapies are desperately needed to target the progression of cancer. Lysyl oxidase (LOX) plays a pivotal role in cancer progression, including metastasis, and is therefore is an attractive therapeutic target.
Perryman, Lara, Erler, Janine Terra
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A microassay for lysyl oxidase activity
Analytical Biochemistry, 1976 Abstract Pinnell and Martin's [(1968) Proc. Nat. Acad. Sci. USA61, 708–716] standard assay for lysyl oxidase is modified to determine activity in small samples. Data collected by both methods are comparable, and the microassay has the advantages of being economical and rapid.
Misiorowski, Ronald L. +2 more
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Lysyl oxidase polymorphisms and susceptibility to osteosarcoma. [PDF]
PLoS ONE, 2012 Despite the knowledge of many genetic alterations present in osteosarcoma, the complexity of this disease precludes placing its biology into a simple conceptual framework.
Yang Liu +10 more
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An in situ activity assay for lysyl oxidases [PDF]
Communications Biology, 2021 To address the limitation of inability to detect lysyl oxidase enzymes (LOX) catalytic function associated with diverse disease processes, Wang et al. developed an in situ activity assay by utilizing the reactivity of hydrazides with imines and carbonyls.
Huilei Wang +7 more
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Arteriosclerosis, Thrombosis, and Vascular Biology, 2002 The extracellular matrix proteins collagen and elastin determine, to a large extent, the biomechanical properties of the vessel wall. Both molecules are secreted as monomers, but are posttranslationally modified in the extracellular space in order to generate stable polymers.
Robert Rucker +3 more
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The Interactome of Cancer-Related Lysyl Oxidase and Lysyl Oxidase-Like Proteins [PDF]
Cancers, 2020 The members of the lysyl oxidase (LOX) family are amine oxidases, which initiate the covalent cross-linking of the extracellular matrix (ECM), regulate ECM stiffness, and contribute to cancer progression. The aim of this study was to build the first draft of the interactome of the five members of the LOX family in order to determine its molecular ...
Vallet, Sylvain +4 more
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Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source