Results 11 to 20 of about 13,239 (158)
Origin and evolution of lysyl oxidases [PDF]
Scientific Reports, 2015 Lysyl oxidases (LOX) are copper-dependent enzymes that oxidize primary amine substrates to reactive aldehydes. The best-studied role of LOX enzymes is the remodeling of the extracellular matrix (ECM) in animals by cross-linking collagens and elastin ...
Corcoran, William Peter +3 more
core +5 more sources
Lysyl oxidase polymorphisms and susceptibility to osteosarcoma. [PDF]
PLoS ONE, 2012 Despite the knowledge of many genetic alterations present in osteosarcoma, the complexity of this disease precludes placing its biology into a simple conceptual framework.
Yang Liu +10 more
doaj +3 more sources
An in situ activity assay for lysyl oxidases [PDF]
Communications Biology, 2021 To address the limitation of inability to detect lysyl oxidase enzymes (LOX) catalytic function associated with diverse disease processes, Wang et al. developed an in situ activity assay by utilizing the reactivity of hydrazides with imines and carbonyls.
Huilei Wang +7 more
doaj +3 more sources
Arteriosclerosis, Thrombosis, and Vascular Biology, 2002 The extracellular matrix proteins collagen and elastin determine, to a large extent, the biomechanical properties of the vessel wall. Both molecules are secreted as monomers, but are posttranslationally modified in the extracellular space in order to generate stable polymers.
Bank, R.A., Hinsbergh, V.W.M. van
openaire +3 more sources
The Interactome of Cancer-Related Lysyl Oxidase and Lysyl Oxidase-Like Proteins [PDF]
Cancers, 2020 The members of the lysyl oxidase (LOX) family are amine oxidases, which initiate the covalent cross-linking of the extracellular matrix (ECM), regulate ECM stiffness, and contribute to cancer progression. The aim of this study was to build the first draft of the interactome of the five members of the LOX family in order to determine its molecular ...
Sylvain D. Vallet +4 more
openaire +2 more sources
Multifunctional Lysyl Oxidases
International Journal of Molecular Sciences, 2023 This Special Issue on lysyl oxidases, which are proteins derived from five related genes known as Lox, and Loxl1–Loxl4, brings together articles that reflect some of the diverse approaches and perspectives needed to better understand the biology of these multifunctional proteins [...]
openaire +2 more sources
Focus on Molecules: Lysyl oxidase [PDF]
Experimental Eye Research, 2012 1. StructureLysyl Oxidase (LOX, also called protein-lysine 6-oxidase)(Genbank accession numbers: Nucleotide NM_002317.5, ProteinNP_002308.2, EC 1.4.3.13) is one of the five LOX family members(LOX and LOX Like1-4). The human LOX gene is located onchromosome 5q23.2.
Anirudh, Sethi +2 more
openaire +2 more sources
β-catenin signaling and regulation of cyclin D1 promoter in NRK-49F cells transformed by down-regulation of the tumor suppressor lysyl oxidase [PDF]
, 1919 Lysyl oxidase is the enzyme that is essential for collagen and elastin cross-linking. Previous investigations showed that lysyl oxidase is down-regulated in many human tumors and ras-transformed cells.
Giampuzzi, Monia +4 more
core +1 more source
Diagnostics, 2021 (1) Background: Lysyl oxidase (LOX) plays a dual role in carcinogenesis and studies show a higher risk of cancer in LOX G473A variants. The present study evaluated the pattern of LOX G473A polymorphism (rs1800449) and serum LOX levels in ovarian cancer ...
Suchitra Kumari +4 more
doaj +1 more source
A Phase II, Randomized, Double-Blind, Placebo-Controlled Study of Simtuzumab in Combination with FOLFIRI for the Second-Line Treatment of Metastatic KRAS Mutant Colorectal Adenocarcinoma. [PDF]
, 2017 Lessons learnedThe safety profile in the patient groups who received FOLFIRI and simtuzumab did not differ from that in the FOLFIRI and placebo group.The addition of simtuzumab to chemotherapy with FOLFIRI does not improve clinical outcomes in patients ...
Bendell, Johanna +5 more
core +1 more source