Examining the Effect of Inhibition of Lysyl oxidase on Involved Genes in Hypertrophy Following One Period of Resistance Training in Wistar Rats [PDF]
Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2018 Background: Recent Research has pointed to the involvement of lysyl oxidase (LOX) in the muscle development. Despite the fact, there is currently no direct evidence that lox is involved in the myogenic factors and exercise-induced hypertrophy. Therefore,
Moein Rahimi Sadegh +3 more
doaj
Circadian clock molecule REV-ERBα regulates lung fibrotic progression through collagen stabilization
Nature Communications, 2023 The molecular clock REV-ERBα regulates lung injury during fibrosis, but the role of REV-ERBα in fibrogenesis remains unknown. Here, the authors show that REV-ERBα interacts with the lysyl oxidase-collagen axis during fibrogenesis and demonstrate the ...
Qixin Wang +6 more
doaj +1 more source
Impact of treatment on myocardial lysyl oxidase expression and collagen cross-linking in patients with heart failure [PDF]
, 2009 The aim of this study was to investigate whether torasemide modifies collagen cross-linking in the failing human heart. We analyzed the degree of cross-linking and the expression of the enzyme lysyl oxidase, which regulates cross-linking, in the ...
Beaumont, J. (Javier) +5 more
core
Cooperative Effect of miR-141-3p and miR-145-5p in the Regulation of Targets in Clear Cell Renal Cell Carcinoma [PDF]
, 2016 Background Due to the poor prognosis for advanced renal cell carcinoma (RCC), there is an urgent need for new therapeutic targets and for prognostic markers to identify high risk tumors.
Busch, Jonas +5 more
core +4 more sources
The invertebrate Caenorhabditis elegans biosynthesizes ascorbate. [PDF]
, 2015 l-Ascorbate, commonly known as vitamin C, serves as an antioxidant and cofactor essential for many biological processes. Distinct ascorbate biosynthetic pathways have been established for animals and plants, but little is known about the presence or ...
Adler, Lital N +5 more
core +2 more sources
Proteomic characterization of type I collagen N-terminal crosslinked peptides
Matrix Biology PlusCollagen cross-links mediated by the lysyl oxidase and lysyl hydroxylase families of enzymes significantly contribute to the biomechanical strength and rigidity of tissues, influencing cell signaling and the downstream cell phenotype.
Zsuzsanna Darula +12 more
doaj +1 more source
Recent advances in understanding idiopathic pulmonary fibrosis [PDF]
, 2016 Despite major research efforts leading to the recent approval of pirfenidone and nintedanib, the dismal prognosis of idiopathic pulmonary fibrosis (IPF) remains unchanged.
Daccord, C, Maher, TM
core +3 more sources
LOXL2 in anabolic response to chondrodysplasia mice progressive TMJ and knee osteoarthritis [PDF]
, 2019 Osteoarthritis (OA) is a degenerative joint disease that affects an estimated 9.6 % of men and 18 % of women over 60 years of age. However, there is no chondroprotective agent that is approved for clinical application.
Alsaqer, Saqer
core
Association between a common missense variant in LOXL3 gene and the risk of non-syndromic cleft palate [PDF]
, 2018 To investigate possible association between functional common variants in the lysyl oxidase like 3 gene and non-syndromic cleft palate we selected a common missense variant p.Ile615Phe (rs17010021), which was predicted to have a probably damaging effect ...
Andreasi, Rita Bassi +6 more
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LOXL2 catalytically inactive mutants mediate epithelial-to-mesenchymal transition
Biology Open, 2014 Summary Lysyl-oxidase-like 2 (LOXL2) is a member of the lysyl oxidase family that catalyzes the cross-linking of collagens or elastins in the extracellular matrix, thus regulating the tensile strength of tissues.
Eva P. Cuevas +5 more
doaj +1 more source