Results 51 to 60 of about 155,219 (227)

Nascent Extracellular Matrix Converts Biomaterial Cues into Cell Fate Decisions

Advanced Science, EarlyView.
This study uncovers a tri‐directional interplay among cells, hydrogels, and their nascent extracellular matrix. Hydrogel norbornene modification alters CD44‐mediated cell–hydrogel interactions, which shape nascent matrix deposition, composition, and spatial organization.
Joshua Y. Liu, Ziqian Yang, Arina E. Velieva, Eleanor M. Plaster, Mingyue Fan, Donia W. Ahmed, Avinava Roy, Pamela Duran, Pamela Panovich, Alexandra S. Piotrowski‐Daspit, Carlos A. Aguilar, Megan L. Killian, Claudia Loebel   +12 more
wiley   +1 more source

Examining the Effect of Inhibition of Lysyl oxidase on Involved Genes in Hypertrophy Following One Period of Resistance Training in Wistar Rats [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2018
Background: Recent Research has pointed to the involvement of lysyl oxidase (LOX) in the muscle development. Despite the fact, there is currently no direct evidence that lox is involved in the myogenic factors and exercise-induced hypertrophy. Therefore,
Moein Rahimi Sadegh, Amir Rashidlamir, Ali Akbar Haddad Mashhad Rizeh, Mohammad Soukhtanloo   +3 more
doaj  

FAK Mediated Coordination of Extracellular Matrix Remodeling and Cellular Mechanics Impairs Nanomedicine Delivery in Solid Tumors

Advanced Science, EarlyView.
FAK orchestrates a mechanical barrier limiting nanomedicine accumulation in solid tumors by coupling ECM remodeling with cytoskeletal tension. Genetic or pharmacological FAK inhibition dismantles this barrier, enhances clathrin‐mediated uptake and penetration, and overcomes delivery limitations to improve antitumor efficacy.
Tian Zhao, Hao Wu, Yujie Qin, Jingfei Zhu, Ye Huang, Wei Chen, Jiaxuan Yu, Xiang Qin, Shun Li, Junjie Li, Tingting Li, Yiyao Liu   +11 more
wiley   +1 more source

Regulation of lysyl oxidase in vascular cells: lysyl oxidase as a new player in cardiovascular diseases [PDF]

Cardiovascular Research, 2008
Lysyl oxidase (LOX) plays a crucial role in the maintenance of extracellular matrix stability and could participate in vascular remodelling associated with cardiovascular diseases. Evidence from in vitro and in vivo studies shows that LOX downregulation is associated with the endothelial dysfunction characteristic of earlier stages of the ...
Rodríguez-Sinovas, Cristina, Martínez-González, José, Raposo, Berta, Alcudia, Javier F., Guadall, Anna, Badimón Maestro, Lina   +5 more
openaire   +2 more sources

Monoclonal Antibodies to Human Lysyl Oxidase

, 1986
Hybridoma antibodies against human lysyl oxidase were produced by fusing Sp. 2.0-Ag 14 myeloma cells with spleen cells from mice hyperimmunized with lysyl oxidase isolated from umbilical cords.
Burbelo, Peter D., Chichester, Clinton O., Monckeberg,   +2 more
core   +1 more source

Circadian clock molecule REV-ERBα regulates lung fibrotic progression through collagen stabilization

Nature Communications, 2023
The molecular clock REV-ERBα regulates lung injury during fibrosis, but the role of REV-ERBα in fibrogenesis remains unknown. Here, the authors show that REV-ERBα interacts with the lysyl oxidase-collagen axis during fibrogenesis and demonstrate the ...
Qixin Wang, Isaac Kirubakaran Sundar, Joseph H. Lucas, Jun-Gyu Park, Aitor Nogales, Luis Martinez-Sobrido, Irfan Rahman   +6 more
doaj   +1 more source

AI‐Assisted Ultrasensitive Biosensing using Metal‐Electrolyte‐Metal‐Insulator‐Silicon Structure Based on Oxygen‐Tunable Iridium Oxide Nanonets for Lysyl‐Oxidase‐Like‐2 Breast Cancer Detection

Advanced Electronic Materials, EarlyView.
An oxygen‐controlled iridium‐oxide (IrOx) nano‐net structure is developed to enhance the sensitivity of metal‐electrolyte‐metal‐insulator‐silicon (MEMIS) biosensors. Integrated with a deep learning model, this platform achieves a high accuracy of 94.8% for detecting the breast cancer biomarker LOXL2.
Chiao‐Fan Chiu, Pankaj Kumar, Long Nguyen Minh Le, Ping‐Hsuan Wu, Punnatorn Boonyoung, Shen Tingyang, Abhijit Aich, Yi‐Pin Chen, Shih‐Yin Huang, Siddheswar Maikap   +9 more
wiley   +1 more source

Lysyl oxidase expression and inhibition in uveal melanoma

, 2010
Lysyl oxidase is a marker of poor prognosis in several malignancies and is hypothesized to promote a migratory phenotype in hypoxic breast carcinomas. This study aims to characterize the expression of the lysyl oxidase and lysyl oxidase-like proteins in ...
Orellana, Maria E., Antecka, Emilia, Petruccelli, Luca A., Martins, Claudia, Burnier, Miguel N. [UNIFESP], Abourbih, Daniel A., Di Cesare, Sebastian, Emilia Antecka, Claudia Martins, Miguel N. Burnier, Sebastian Di Cesare, Luca A. Petruccelli, Maria E. Orellana, Daniel A. Abourbih   +13 more
core   +1 more source

Nanofabricated Biomaterials Model Tumor Extracellular Matrix Topography

Advanced NanoBiomed Research, EarlyView.
The unique structure and composition of the tumor microenvironment and its associated extracellular matrix (ECM) exert profound effects on cancer cell behavior that are difficult to model in vitro. This perspective discusses the utility of nanofabricated biosubstrates, such as the novel collagen‐coated nanogrooved array, for recapitulating the ...
Vic Zamloot, JinSeok Park
wiley   +1 more source

Characterization of Recombinant Lysyl Oxidase Propeptide [PDF]

Biochemistry, 2010
Lysyl oxidase enzyme activity is critical for the biosynthesis of mature and functional collagens and elastin. In addition, lysyl oxidase has tumor suppressor activity that has been shown to depend on the propeptide region (LOX-PP) derived from pro-lysyl oxidase (Pro-LOX) and not on lysyl oxidase enzyme activity.
Siddharth R, Vora, Ying, Guo, Danielle N, Stephens, Erdjan, Salih, Emile D, Vu, Kathrin H, Kirsch, Gail E, Sonenshein, Philip C, Trackman   +7 more
openaire   +2 more sources