Results 41 to 50 of about 165,472 (305)

Neurothekeoma of petrous apex: A rare entity

Indian Journal of Neurosurgery, 2013
Intraosseous nerve sheath tumors are very rare tumors accounting for lesser than 0.2% of primary bone tumors. We present an 18-year-old female who presented with left facial paresis for the last 1 year.
Zarina Abdul Assis, Sunitha P. Kumaran, Nandita Ghosal, Saikiran Narayanam, Sanjaya Viswamitra   +4 more
doaj   +1 more source

Microscopy deep learning predicts virus infections and reveals mechanics of lytic-infected cells

iScience, 2021
Summary: Imaging across scales reveals disease mechanisms in organisms, tissues, and cells. Yet, particular infection phenotypes, such as virus-induced cell lysis, have remained difficult to study.
Vardan Andriasyan, Artur Yakimovich, Anthony Petkidis, Fanny Georgi, Robert Witte, Daniel Puntener, Urs F. Greber   +6 more
doaj   +1 more source

Complexities associated with expression of Epstein-Barr virus (EBV) lytic origins of DNA replication. [PDF]

, 2007
EBV has two lytic origins (oriLyt) of DNA replication lying at divergent sites on the viral genome within a duplicated sequence (DS). The latter contains potential hairpin loops, ‘hinge’ elements and the promoters for transcripts from viral genes BHLF1 ...
Xue, SA, Griffin, BE
core  

Heterogeneity of viral IL-6 expression in HHV-8-associated diseases. [PDF]

, 2007
In order to characterize the expression of the viral interleukin-6 (vIL-6) homologue in various human herpesvirus 8 (HHV-8)-associated diseases, in situ hybridization and immunohistochemistry were applied to formalin-fixed specimens.
Cesarman, Ethel, Nicholas, John, Cannon, Jennifer S., Murray, Paul G., Ambinder, Richard F., Orenstein, Jan M., Mann, Risa B., DiGiuseppe, Joseph A., Hayward, Gary S., Browning, Philip J.   +9 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Isolation and Characterization of Highly Lytic Bacteriophages against Staphylococcus aureus in Malaysian Sewage Water

Journal of Pure and Applied Microbiology
Staphylococcus aureus is a pathogen that can cause both minor and life-threatening infection to human. Recently, the emergence of antibiotic-resistant Staphylococcus aureus (MRSA) has become a global public health concern.
Jyng Sheng Tee, Bihe Chen, Chin Mei Lee
doaj   +1 more source

Stepwise maturation of lytic granules during differentiation and activation of human CD8+ T lymphocytes. [PDF]

PLoS ONE, 2011
During differentiation, cytotoxic T lymphocytes (CTL) acquire their killing potential through the biogenesis and maturation of lytic granules that are secreted upon target cell recognition.
Yovan Sanchez-Ruiz, Salvatore Valitutti, Loic Dupre   +2 more
doaj   +1 more source

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source

Epstein‐Barr Virus Transformed B Cells From Systemic Lupus Erythematosus and Multiple Sclerosis Patients Differ in EBV Lytic and Latency Marker Expression

Immunity, Inflammation and Disease
Epstein‐Barr virus (EBV) is an important environmental risk factor in the development of several autoimmune conditions, with the mechanisms still to be fully elucidated.
Ali Afrasiabi, Wade J. Bocking, Stephen D. Schibeci, Samantha P. L. Law, Nicole L. Fewings, Ming‐Wei Lin, Stephen J. Sawcer, Maria Ban, Sanjay Swaminathan, Grant P. Parnell   +9 more
doaj   +1 more source

Endosomal Escape of siRNA Polyplexes: A Molecular Dynamics Perspective on Underlying Mechanisms

Advanced Functional Materials, EarlyView.
Molecular dynamics simulations reveal distinct endosomal escape mechanisms of siRNA nanoparticles, ranging from electrostatic membrane attachment to hydrophobic membrane fusion. Hydrophobic residues and anionic endosomal lipids emerge as key determinants of membrane disruption, linking molecular interactions to experimental delivery performance and ...
Katharina M. Steinegger, Min Jiang, Florian Belger, Fabian Link, Benjamin Winkeljann, Olivia M. Merkel   +5 more
wiley   +1 more source