NEDDylation is essential for Kaposi's sarcoma-associated herpesvirus latency and lytic reactivation and represents a novel anti-KSHV target. [PDF]
, 2015 Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL), which are aggressive malignancies associated with immunocompromised patients.
Wood, Jennifer J +19 more
core +1 more source
Multifaceted Roles of ICP22/ORF63 Proteins in the Life Cycle of Human Herpesviruses
Frontiers in Microbiology, 2021 Herpesviruses are extremely successful parasites that have evolved over millions of years to develop a variety of mechanisms to coexist with their hosts and to maintain host-to-host transmission and lifelong infection by regulating their life cycles. The
Ying Wu +49 more
doaj +1 more source
Real-time transcriptional profiling of cellular and viral gene expression during lytic cytomegalovirus infection. [PDF]
, 2012 During viral infections cellular gene expression is subject to rapid alterations induced by both viral and antiviral mechanisms. In this study, we applied metabolic labeling of newly transcribed RNA with 4-thiouridine (4sU-tagging) to dissect the real ...
Lisa Marcinowski +46 more
core +1 more source
Mucin and Agitation Shape Predation of Escherichia coli by Lytic Coliphage
Microorganisms, 2023 The ability of bacteriophage (phage), abundant within the gastrointestinal microbiome, to regulate bacterial populations within the same micro-environment offers prophylactic and therapeutic opportunities.
Amanda Carroll-Portillo +7 more
doaj +1 more source
Moderate Seasonal Dynamics Indicate an Important Role for Lysogeny in the Red Sea
Microorganisms, 2021 Viruses are the most abundant microorganisms in marine environments and viral infections can be either lytic (virulent) or lysogenic (temperate phage) within the host cell. The aim of this study was to quantify viral dynamics (abundance and infection) in
Ruba Abdulrahman Ashy +2 more
doaj +1 more source
Cyclic GMP signaling during the lytic cycle of Toxoplasma gondii [PDF]
, 2019 Der cGMP-Signalweg ist als einer der Hauptregulatoren von diversen Funktionen in Eukaryoten bekannt; allerdings ist seine Funktionsweise in Protozoen wenig verstanden.
Günay-Esiyok, Özlem
core +1 more source
Viruses, 2021 The interaction between gut bacterial and viral microbiota is thought to be important in human health. While fluctuations in female genital tract (FGT) bacterial microbiota similarly determine sexual health, little is known about the presence ...
Anna-Ursula Happel +10 more
doaj +1 more source
Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei. [PDF]
, 2014 Closely related African trypanosomes cause lethal diseases but display distinct host ranges. Specifically, Trypanosoma brucei brucei causes nagana in livestock but fails to infect humans, while Trypanosoma brucei gambiense and Trypanosoma brucei ...
Currier, Rachel B. +18 more
core +1 more source
Neurothekeoma of petrous apex: A rare entity
Indian Journal of Neurosurgery, 2013 Intraosseous nerve sheath tumors are very rare tumors accounting for lesser than 0.2% of primary bone tumors. We present an 18-year-old female who presented with left facial paresis for the last 1 year.
Zarina Abdul Assis +4 more
doaj +1 more source
Exploring Antimicrobial Peptides Efficacy against Fire Blight (Erwinia amylovora)
Plants, 2022 Antimicrobial peptides (AMPs) are a various group of molecules found in a wide range of organisms and act as a defense mechanism against different kinds of infectious pathogens (bacteria, viruses, and fungi, etc.).
Miloud Sabri +6 more
doaj +1 more source