Results 81 to 90 of about 165,472 (305)

A Multi‐Targeting Chimeric Antigen Receptor‐T Cell Platform to Overcome Antigen Heterogeneity in the Treatment of Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A dual‐transmembrane Bicephali CAR‐T platform simultaneously targets CD276 and NKG2D ligands to address antigen heterogeneity in non‐small cell lung cancer. By improving immune synapse formation, mitochondrial fitness, antioxidant capacity, and stem‐like persistence, this design enhances durable tumor control and provides a versatile strategy to ...
Lina Wang, Yanlei Zhang, Shuixiu Peng, Chenchen Hou, Huaqi Guo, Tianyu Zhou, Alex H. Chang, Lifeng Yan, Weining Xiong   +8 more
wiley   +1 more source

YpeB stability affects germination possibly through delaying SleB activity in Bacillus subtilis

Journal of Bacteriology
Bacterial endospores formed by Bacilli and Clostridia can persist for decades and survive a wide range of killing mechanisms but can rapidly germinate in permissive environments.
Marcel Shams-Eddin, Alexandra Pinkham, Naomi Williams, David L. Popham   +3 more
doaj   +1 more source

Can Non-Lytic CD8+ T cells Drive HIV-1 Escape [PDF]

, 2013
The CD8+ T cell effector mechanisms that mediate control of HIV-1 and SIV infections remain poorly understood. Recent work suggests that the mechanism may be primarily non-lytic.
Graw, F, Konstantinos Chatzimichalis (485230), Frost, SDW, Konstantinos Chatzimichalis, Graw, Frederik, Asquith, B, Frederik Graw, Roland R. Regoes, Frost, Simon D.W., Becca Asquith (61803), Simon D. W. Frost (155011), Frederik Graw (175938), Regoes, Roland R., Seich al Basatena, Nafisa-Katrin, Chatzimichalis, Konstantinos, Chatzimichalis, K, Regoes, RR, Simon D. W. Frost, Simon D W Frost, Roland R Regoes, Becca Asquith, Roland R. Regoes (121293), Nafisa-Katrin Seich Al Basatena, Asquith, Becca, Nafisa-Katrin Seich al Basatena (201133), Seich al Basatena, NK   +25 more
core   +1 more source

Low‐Density Lipoprotein Receptor‐Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption

Advanced Science, EarlyView.
A low‐density lipoprotein receptor‐oriented biomimetic nanoplatform couples brain‐tumor delivery with a mechanistically matched regorafenib‐erythrodiol combination. Concurrent disruption of autophagic nutrient salvage and cholesterol homeostasis collapses bioenergetic and signaling support, suppresses glioblastoma stemness, and promotes immunogenic ...
Yining Jiang, Wenzhuo Yang, Wenting Cheng, Jing Zuo, Lin Pan, Sheng Zhong, Ren Geng, Yao Zhao, Zijian Chen, Canhua Huang, Yang Bai, Liyan Zhao, Yunqian Li   +12 more
wiley   +1 more source

Gammaherpesvirus infection of myeloid cells reveals divergent outcomes regulated by host and viral factors

iScience
Summary: The gammaherpesviruses establish a lifelong infection, with the cellular outcome of infection intimately regulated by cell type. Myeloid cells are an early infection target characterized by diverse outcomes.
Gabrielle Vragel, Kyra S. Noell, Ashley Tseng, Rachael E. Kostelecky, Elizabeth A. Alexander, Shirli Cohen, Catalina Galvan, Manaal Dalwadi, Brittany D. Gomez, Eva M. Medina, Darby G. Oldenburg, Andrew Goodspeed, Eric T. Clambey, Linda F. van Dyk   +13 more
doaj   +1 more source

A Biomimetic cRGDyk‐Engineered Platelet Nanoplatform for ACAD11 Delivery to Trigger Pyroptosis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A biomimetic platelet nanoplatform (OE‐ACAD11@R‐PLT) is developed for targeted hepatocellular carcinoma immunotherapy. By selectively delivering therapeutic plasmids, this system induces mitochondrial dysfunction and triggers robust NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis in tumor cells.
Hongyi Bao, Wei Feng, Wei Zong, Yi Li, Xinyue Qin, Xinyue Wang, Yubo Yang, Guanhua Chen, Yiting Hou, Xuan Tan, Lin Chen, Ming Zhang, Feng Wang   +12 more
wiley   +1 more source

Regulation of KSHV Lytic Switch Protein Expression by a Virus-Encoded MicroRNA: An Evolutionary Adaptation that Fine-Tunes Lytic Reactivation [PDF]

, 2009
SummaryHerpesviruses encode numerous microRNAs (miRNAs), most of whose functions are unknown. The Kaposi's sarcoma-associated herpesvirus (KSHV) encodes 17 known miRNAs as part of its latency program, suggesting that these RNAs might function to regulate
Bellare, Priya, Ganem, Don
core   +1 more source

Intratumoral Fusogenic Outer Membrane Vesicles Enhance Antitumor Immunity Through Tumor MHC‐I Upregulation and Tumor Bacterization

Advanced Science, EarlyView.
Tumor bacterization by fusogenic outer membrane vesicles enhances microbial‐like recognition of tumor cells while activating the TLR4–NF‐κB–NLRC5 axis to upregulate MHC class I expression. By simultaneously strengthening APC sensing and T‐cell recognition, this strategy breaks tumor immune invisibility and promotes more effective antitumor immune ...
Xing Liu, Jiaxin Zhou, Guihong Lu, Chenjing Zhao, Weixiu Wang, Jichuan Chen, Fengqi Zhang, Fan Zhang, Hai‐Yan Xie, Weidong Nie   +9 more
wiley   +1 more source

Development of Versatile Nanoparticle System for Efficient Drug Delivery into Pulmonary Endothelium

Advanced Science, EarlyView.
Pediatric acute respiratory distress syndrome (PARDS) suppresses the FOXF1 transcription factor and disrupts lung development. This study shows that the FOXF1‐activating small‐molecule compound, TanFe[F], can be precisely delivered to lung endothelial cells using the innovative LEDD nanoparticle system.
Afzaal N. Mohammed, Zicheng Deng, Arnab Misra, Marcus Orzabal, Ananya Kondapally, Enhong Li, Jonathan Do, Ying‐Wei Lan, Fatemeh Kohram, Hunter Blackburn, Andreas Damianos, Tanya V. Kalin, Vladimir V. Kalinichenko   +12 more
wiley   +1 more source

Lytic vertebral lesions (g55).

, 2019
Lytic vertebral lesions (g55).
Thomas Reitmaier (2620993), Bernd Heinzle (6680948), Christine Cooper (3276291)   +2 more
core   +1 more source