Results 91 to 100 of about 152,902 (307)
Advanced Science, EarlyView.Cholesterol‐enriched plasma membranes in hepatocellular carcinoma impede drug penetration. Cholesterol (+)‐liposomes act as membrane‐specific detergents, extracting cholesterol and reducing barrier function without cytotoxicity. Following endocytosis, cholesterol transfers from endosomes to liposomes and is metabolized in the ER.
Chansik Kim +9 more
wiley +1 more source
Effect of pH on PlyPl23 lytic activity.
, 2015 PlyPl23 activity on P. larvae Pl02-23 at different pH values, ranging from 5 to 9. Relative lytic activity was obtained as the ratio between the lytic activity of each test and the highest value obtained (the reference value was 70.9% lytic activity ...
Leon D. Kluskens (640869) +5 more
core +1 more source
Advanced Science, EarlyView.Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang +8 more
wiley +1 more source
The central role of the chaperome in maintaining cellular proteostasis has seen numerous viral families evolve to parasitically exploit host chaperones in their life cycle. The HSP90 chaperone protein and its co-chaperone Hop, have both individually been
Alhassan, Mahama +7 more
core +1 more source
Studies on marine bacteria producing lytic enzymes - VIII : Release of lytic enzyme from bacterial cells [PDF]
, 1983 application/pdfThe release of lytic enzyme was studied by washing and suspending the cells in solutions containing inorganic salts or organic anions. The ratio of lytic enzyme released into culture fluids to the total lytic enzyme produced during the ...
Jinno, Chikara +3 more
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Advanced Science, EarlyView.Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung +39 more
wiley +1 more source
The immune control exerted by lytic and non-lytic CD8+ T cell responses.
, 2013 (A) The frequency of productively infected cells at setpoint for varying probability of CD8+ T cell recognition and for different secretion patterns. As the probability of recognition increases, the frequency of infected cells decreases for the lytic ...
Roland R. Regoes (121293) +5 more
core +1 more source
, 2021 Metalloproteins perform a diverse array of redox-related reactions facilitated by the increased chemical functionality afforded by their metallocofactors.
Pratul K., Agarwal +4 more
core +1 more source
The HCMV‐encoded miR‐UL36‐3p promotes angiogenesis of endothelial cells by downregulating FOXO3
Animal Models and Experimental Medicine, EarlyView.This illustration shows the role of hcmv‐miR‐UL36‐3p in endothelial cell angiogenesis. During productive infection, endothelial cells express HCMV‐encoded miRNAs. Viral hcmv‐miR‐UL36‐3p promotes endothelial cell proliferation, migration, and capillary tube formation by directly targeting and downregulating FOXO3. The pro‐angiogenic activity of hcmv‐miR‐
Chen Wang +5 more
wiley +1 more source
Immune Responses to Epstein-Barr Virus Lytic Proteins in Patients with Nasopharyngeal Carcinoma
, 2009 Immune responses to three Epstein-Barr virus (EBV) lytic proteins, DNase, thymidine kinase (TK), and BMRF-1 gene products (50/52 kDa diffused early antigen, EA-D complex) were determined in EBV-infected control individuals and patients with ...
LIU, MEI-YING;HUANG, YU-TZU;SHEEN, TZUNG-SHIAHN;CHEN, JEN-YANG;TSAI, CHING-HWA ANN +1 more
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