Results 91 to 100 of about 165,472 (305)

Chrysin attenuates diabetes‐induced retinal injury by inhibiting microglial GBP3/NLRP3/GSDMD‐mediated pyroptosis

open access: yesAnimal Models and Experimental Medicine, EarlyView.
We investigated the therapeutic potential and mechanism of chrysin in experimental diabetic retinal disease. Using a streptozotocin (STZ)‐induced diabetic mouse model and high‐glucose‐stimulated BV2 microglia, we revealed chrysin‐responsive pyroptosis‐associated signatures and identified GBP3 as a regulated node.
Qun Liu   +9 more
wiley   +1 more source

Behavior and Properties of Mature Lytic Granules at the Immunological Synapse of Human Cytotoxic T Lymphocytes.

open access: yesPLoS ONE, 2015
Killing of virally infected cells or tumor cells by cytotoxic T lymphocytes requires targeting of lytic granules to the junction between the CTL and its target.
Min Ming   +4 more
doaj   +1 more source

Minimum lytic concentrations.

open access: yes, 2015
Minimum lytic concentrations.
Reed M. Stubbendieck (835029)   +1 more
core   +1 more source

Paleopathology of a putative colossosaurian caudal vertebra (Neosauropoda: Titanosauria) from the Presidente Prudente Formation, Brazil

open access: yesThe Anatomical Record, EarlyView.
Abstract Studies investigating paleopathologies in sauropods remain scarce despite their relative abundance in the fossil record. In this study we report new occurrence of paleopathological features, corresponding to a neoplasm found in a middle caudal vertebra (MCT.R.2120) of an advanced titanosaur from the Presidente Prudente Formation (Bauru Basin ...
Maria Luiza Peres Bertolossi   +5 more
wiley   +1 more source

Effect of pH on PlyPl23 lytic activity.

open access: yes, 2015
PlyPl23 activity on P. larvae Pl02-23 at different pH values, ranging from 5 to 9. Relative lytic activity was obtained as the ratio between the lytic activity of each test and the highest value obtained (the reference value was 70.9% lytic activity ...
Leon D. Kluskens (640869)   +5 more
core   +1 more source

Multivariate Analysis of Hematological Stress Biomarkers and Welfare Domains in Organic and Intensive Pig Farming in Italy: A Pilot Study

open access: yesAnimal Research and One Health, EarlyView.
Intensive or organic farming systems may expose pigs to management or environmental challenges. Our preliminary results concluded that organic farming might enhance adaptive immune function, showing that improvements in welfare can translate into measurable immunological benefits, based on the correlation between welfare assessment and physiological ...
Dorotea Ippolito   +15 more
wiley   +1 more source

Characterising the adaptive t-cell immune response against Kaposi’s sarcoma-associated herpesvirus [PDF]

open access: yes, 2010
Kaposi’s sarcoma-associated herpesvirus (KSHV) is causally related to Kaposi’s sarcoma (KS), the most common malignancy in individuals with untreated HIV/AIDS.
Robey, R.C.
core  

The algae-lytic ability of bacterium DC10 and the influence of environmental factors on the ability

open access: yes, 2005
A lysing-bacterium DC10, isolated from Dianchi Lake of Yunnan Province, was characterized to be Pseudomonas sp. It was able to lyse some algae well, such as Microcystis viridis, Selenastrum capricomutum, and so on.
Li, GB   +4 more
core   +1 more source

Cell and Gene Therapies Manufacturing Challenges and Integrated Good Manufacturing Practices Solutions: A Lifecycle Perspective

open access: yesBiotechnology and Bioengineering, EarlyView.
Lifecycle perspective on cell and gene therapy manufacturing challenges and enabling GMP solutions. ABSTRACT Cell and gene therapies (CGTs) are revolutionizing modern medicine; however, making these advanced medicines scalable and readily available to commercial manufacturers worldwide is a major challenge. The number of approved CGT products continues
Rajath Samaga   +2 more
wiley   +1 more source

Immune Responses to Epstein-Barr Virus Lytic Proteins in Patients with Nasopharyngeal Carcinoma

open access: yes, 2009
Immune responses to three Epstein-Barr virus (EBV) lytic proteins, DNase, thymidine kinase (TK), and BMRF-1 gene products (50/52 kDa diffused early antigen, EA-D complex) were determined in EBV-infected control individuals and patients with ...
LIU, MEI-YING;HUANG, YU-TZU;SHEEN, TZUNG-SHIAHN;CHEN, JEN-YANG;TSAI, CHING-HWA ANN   +1 more
core  

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