Results 121 to 130 of about 100,112 (246)

Lytic Transglycosylase Deficiency Increases Susceptibility to β‐lactam Antibiotics But Reduces Susceptibility to Vancomycin in Escherichia coli

Microbiology and Immunology, EarlyView.
ABSTRACT In Staphylococcus aureus, a gram‐positive pathogen, vancomycin‐resistant strains become susceptible to β‐lactam antibiotics, referred to as the “seesaw effect.” However, in gram‐negative bacteria, the phenomenon is less clear. Here, we analyzed the gene‐knockout effects of eight lytic transglycosylases (slt, mltA, mltB, mltC, mltD, mltE, mltF,
Takahiko Kimura, Kazuya Ishikawa, Ryosuke Nakagawa, Kazuyuki Furuta, Chikara Kaito   +4 more
wiley   +1 more source

Aggressive Neoplasms That Mimic Chronic Endodontic Lesions: A Multi‐Institutional Case Series

Australian Endodontic Journal, EarlyView.
ABSTRACT This study aimed to report sociodemographic, clinicopathologic and radiological features of 12 cases of aggressive neoplasms that were clinically diagnosed as chronic endodontic lesions. The series comprised seven females (58.33%) and five males (41.67%), with a mean age of 48.9 ± 19.19 years (range: 16–75 years).
Natália Gonçalves Macedo, Fernanda Geraldo Pappen, Bernardo da Fonseca Orcina, Gustavo Mascarenhas, Jean Nunes dos Santos, Paulo Sérgio da Silva Santos, Carolina Clasen Vieira, Alexandre Simões Garcia, Alini Cardoso Soares, Lauren Frenzel Schuch, Ana Paula Neutzling Gomes, Ana Carolina Uchoa Vasconcelos   +11 more
wiley   +1 more source

From DNA sequence to application: possibilities and complications [PDF]

, 1999
The development of sophisticated genetic tools during the past 15 years have facilitated a tremendous increase of fundamental and application-oriented knowledge of lactic acid bacteria (LAB) and their bacteriophages.
A Bruttin, A Bruttin, A Kraus, A Nauta, A Nauta, A Nauta, A Sazicu, AK Aggarwal, B Christiansen, B Christiansen, BC Lokman, BC Lokman, BM Chassy, C Delorme, C Hill, C Schouler, CA Alpert, CA Shearman, CJ Hueck, CO Pabo, CT Verrips, D Botstein, D Lillehaug, D Lillehaug, D Sinderen, DJ O’Sullivan, DJ O’Sullivan, DO Gostick, DO Gostick, E Küster, E Maguin, E Stanley, EJ Luesink, EJ Luesink, EJ Luesink, F Desiere, F Desiere, G Buist, G Buist, G Ramsay, G Vriend, GM Djordjevic, GM Djordjevic, H Brüssow, H Holo, H Neve, I Biswas, J Bardowski, J Bernhardt, J Green, J Law, J Payne, J Stülke, JB Luchansky, JD Boyce, JW Sanders, JW Sanders, JW Sanders, K Chung, K Leenhouts, K Leenhouts, K Leenhouts, K Schnetz, KI Kodaira, KJ Leenhouts, L Dupont, L Dupont, LJ Beamer, LR Garcia, M Curie, M de Guchte, M de Guchte, M Lieb, M Ptashne, MG Johnsen, MJ Gasson, MJ Weickert, MM Sheehan, MW Lubbers, MW Lubbers, N Goupil-Feuillerat, OP Kuipers, P Hals, PG Ruyter, PGGA Ruyter, PL Madsen, PS Chandry, R Parreira, R Schmid, R Young, R Young, RR Raya, S Challou, S Lucchini, S Lucchini, S Simonen, S Spiro, S Spiro, SA Walker, SB Mclvilc, SG Kim, SM Heller, SM Madsen, SR Swindell, T Sasaki, TM Ramseier, V Vagner, WM Vos, WM Vos, WM Vos, Y Fujita   +110 more
core   +3 more sources

Anions and citrate inhibit LsAA9A, a lytic polysaccharide monooxygenase (LPMO)

The FEBS Journal, EarlyView.
The fungal lytic polysaccharide monooxygenase LsAA9A binds chloride in its crystallization mother liquor, leading to LsAA9A inhibition. Other halides except for fluoride inhibit LsAA9A activity at high concentrations. Transferring crystals to a different solution with lower ionic strength leads to binding of citrate buffer, leading also to the ...
Valerio Di Domenico, Yusuf Theibich, Søren Brander, Jean‐Guy Berrin, Katja S. Johansen, Kristian E. H. Frandsen, Leila Lo Leggio   +6 more
wiley   +1 more source

A guide to heat shock factors as multifunctional transcriptional regulators

The FEBS Journal, EarlyView.
The heat shock factors (HSFs) are evolutionarily conserved transcription factors best known as regulators of molecular chaperone genes in response to heat shock and other protein‐damaging stresses. Vertebrate HSFs, HSF1‐5, HSFX, and HSFY, are implicated in various physiological and pathological processes, including organismal development and cancer ...
Hendrik S. E. Hästbacka, Alejandro J. Da Silva, Lea Sistonen, Eva Henriksson   +3 more
wiley   +1 more source

Comparative genomics of Shiga toxin encoding bacteriophages [PDF]

, 2012
Background Stx bacteriophages are responsible for driving the dissemination of Stx toxin genes (stx) across their bacterial host range. Lysogens carrying Stx phages can cause severe, lifethreatening disease and Stx toxin is an integral virulence factor.
Allison, Heather, Darby, Alistair, Fogg, Paul, McCarthy, Alan, Rooks, David, Smith, Darren, Thomson, Nicholas   +6 more
core   +2 more sources

CD59, Disulphide‐Locked Human C9 and Horse C9 Inhibit Human Membrane Attack Complex Assembly by Similar Mechanisms

Immunology, EarlyView.
The membrane attack complex (MAC) is formed by the stepwise assembly of five proteins: C5b, C6, C7, C8 and C9. MAC plays a key role in driving inflammation in numerous diseases. This study compares the inhibitory mechanisms of MAC assembly by soluble CD59 (sCD59), a disulphide‐locked C9 mutant (C9lock) and horse C9 (HoC9).
Rebekah S. Cooke, Bradley A. Spicer, Richard A. Harrison, Michelle A. Dunstone, B. Paul Morgan, Wioleta M. Zelek   +5 more
wiley   +1 more source

Antimicrobial Peptide‐Peptoid Macrocycles from the Polymyxin B2 Chemical Space

Angewandte Chemie, Volume 137, Issue 23, June 2, 2025.
We optimized mixed peptide‐peptoid sequences for molecular similarity to the macrocyclic lipopeptide antibiotic polymyxin B2 (PMB2) using a genetic algorithm. Synthesis and testing of top‐scoring compounds allowed us to identify new macrocycles with similar antimicrobial activity and reduced toxicity compared to PMB2.
Etienne Bonvin, Markus Orsi, Thierry Paschoud, Ashvin Gopalasingam, Jérémie Reusser, Thilo Köhler, Christian van Delden, Jean‐Louis Reymond   +7 more
wiley   +2 more sources

Molecular mimicry, genetic homology, and gene sharing proteomic “molecular fingerprints” using an EBV (Epstein-Barr virus)-derived microarray as a potential diagnostic method in autoimmune disease [PDF]

, 2018
EBV (Epstein-Barr Virus) and other human DNA viruses are associated with autoimmune syndromes in epidemiologic studies. In this work, immunoglobulin G response to EBV-encoded proteins which share regions with human immune response proteins from the human
Alessandra Farina, Giuseppina, Dreyfus, David H., FARINA, Antonella   +2 more
core   +1 more source

Cryo‐SEM and large volume FIB‐SEM of Arabidopsis cotyledons: Degradation of lipid bodies, biogenesis of glyoxysomes and reorganisation of organelles during germination

Journal of Microscopy, EarlyView.
Abstract Until recently, the lack of three‐dimensional visualisation of whole cells at the electron microscopic (EM) level has led to a significant gap in our understanding of the interaction of cellular organelles and their interconnection. This is particularly true with regard to the role of the endoplasmic reticulum (ER).
Gerhard Wanner, Elizabeth Schroeder‐Reiter, Farhah F. Assaad   +2 more
wiley   +1 more source