Hsa-miR-7974 Suppresses Epstein-Barr Virus Reactivation by Directly Targeting BZLF1 and BRLF1
VirusesEpstein-Barr virus (EBV) reactivation, a key factor in Epstein-Barr virus (EBV)-associated malignancies, is regulated by specific cellular microRNAs (miRNAs). This study investigated the role of Hsa-miR-7974 (miR-7974) in this process.
Haotian Li +8 more
doaj +1 more source
Construction and utilisation of a bidirectional reporter vector in the analysis of two nod-boxes in of Rhizobium loti : a thesis presented in partial fulfilment of the requirements for the Degree of Master of Science in Molecular Genetics at Massey University [PDF]
, 1993 The nod-box is a 47bp cis-acting regulatory region which has been conserved amongst every species of Rhizobium studied to date. In species such as R. meliloti and R.
Parry, Simon Keith
core
Clinical &Experimental Allergy, EarlyView.We found that oesophageal epithelial cells upregulate MHCII expression during active EoE in humans and a mouse model. MHCII expression by EECs was governed by IFNγ‐inducible transcriptional elements. EEC‐intrinsic MHCII promoted regulatory T cell accumulation and attenuated eosinophilic oesophageal inflammation.
Eric M. Rodríguez‐López +12 more
wiley +1 more source
Equine Veterinary Journal, EarlyView.Abstract Background There are limited data on long‐term follow‐up of radiographic changes of the proximal sesamoid bones (PSBs) in Thoroughbred racehorses. The effect of training and racing on radiodensity of the PSBs in live Thoroughbreds has not been described.
Koppány Boros +3 more
wiley +1 more source
Microbiology SpectrumToxoplasma gondii is an obligate intracellular parasite that relies on a complex network of protein kinases to regulate essential processes such as invasion, replication, and egress.
Dima Hajj Ali +3 more
doaj +1 more source
De Novo Protein Synthesis Is Required for Lytic Cycle Reactivation of Epstein-Barr Virus, but Not Kaposi's Sarcoma-Associated Herpesvirus, in Response to Histone Deacetylase Inhibitors and Protein Kinase C Agonists [PDF]
, 2007 Jianjiang Ye +3 more
openalex +1 more source
Fish and Fisheries, EarlyView.Bacteriophage therapy is characterised by numerous advantages, facilitating its diverse aquaculture application and efficacy as an antibiotic alternative mitigating the spread of antimicrobial‐resistant pathogens. Contributing to the modern reappraisal of the aquaculture application of bacteriophage therapy, challenges impeding its widespread ...
Louise James +4 more
wiley +1 more source
ORF48 is required for optimal lytic replication of Kaposi's sarcoma-associated herpesvirus.
PLoS PathogensKaposi's sarcoma-associated herpesvirus (KSHV) establishes persistent infection in the host by encoding a vast network of proteins that aid immune evasion.
Beatriz H S Veronese +4 more
doaj +1 more source
Differential regulation of translational stress responses by herpesvirus ubiquitin deconjugases
The FEBS Journal, EarlyView.Translating viral mRNAs is challenging due to structural features that may slow translation or induce ribosome stalling. The viral ubiquitin deconjugases encoded by human pathogenic herpesviruses regulate the cellular response to ribosomal stress by inhibiting various branches of the Ribosomal Quality Control (RQC) and activating Ribosomal Stress ...
Jiangnan Liu +3 more
wiley +1 more source
Sensing of cardiolipin exposure on plasma membranes of apoptotic cells by EryA‐mCherry protein
The FEBS Journal, EarlyView.An aegerolysin protein erylysin A (EryA) fused with mCherry binds to artificial lipid vesicles supplemented with cardiolipin (CL). This binding is much more specific than that of annexin V, which binds various negatively charged glycerophospholipids (PG, PS, PI). In mammalian cells, the CL exposition at the membrane surface represents an early hallmark
Luka Žeželj +12 more
wiley +1 more source