Valpromide Inhibits Lytic Cycle Reactivation of Epstein-Barr Virus [PDF]
mBio, 2016 Reactivation of Epstein-Barr virus (EBV) from latency into the lytic phase of its life cycle allows the virus to spread among cells and between hosts. Valproic acid (VPA) inhibits initiation of the lytic cycle in EBV-infected B lymphoma cells.
Kelly L. Gorres +5 more
doaj +5 more sources
Mitochondrial behaviour throughout the lytic cycle of Toxoplasma gondii. [PDF]
Sci Rep, 2017 Mitochondria distribution in cells controls cellular physiology in health and disease. Here we describe the mitochondrial morphology and positioning found in the different stages of the lytic cycle of the eukaryotic single-cell parasite Toxoplasma gondii.
Ovciarikova J +4 more
europepmc +8 more sources
Spatial Model for Oncolytic Virotherapy with Lytic Cycle Delay. [PDF]
Bull Math Biol, 2019 We formulate a mathematical model of functional partial differential equations for oncolytic virotherapy which incorporates virus diffusivity, tumor cell diffusion, and the viral lytic cycle based on a basic oncolytic virus dynamics model. We conduct a detailed analysis for the dynamics of the model and carry out numerical simulations to demonstrate ...
Zhao J, Tian JP.
europepmc +7 more sources
EZH2 Inhibition by DS3201 Triggers the Kaposi’s Sarcoma-Associated Herpesvirus Lytic Cycle and Potentiates the Effects Induced by SAHA in Primary Effusion Lymphoma Cells [PDF]
VirusesPrimary Effusion Lymphoma (PEL) cells carry Kaposi’s sarcoma-associated herpesvirus (KSHV) in a latent state, except for a small number of cells in which the virus replicates to ensure its persistence into the infected host.
Roberta Gonnella +5 more
doaj +2 more sources
Immune Modulation by Epstein–Barr Virus Lytic Cycle: Relevance and Implication in Oncogenesis [PDF]
PathogensEBV infects more than 90% of people globally, causing lifelong infection. The phases of the EBV life cycle encompass primary infection, latency, and subsequent reactivation or lytic phase. The primary infection usually happens without noticeable symptoms,
Nevena Todorović +2 more
doaj +2 more sources
Induction of epstein-barr virus (EBV) lytic cycle in vitro causes lipid peroxidation, protein oxidation and DNA damage in lymphoblastoid B cell lines [PDF]
Lipids in Health and Disease, 2011 Background We investigated the oxidative modifications of lipids, proteins and DNA, potential molecular targets of oxidative stress, in two lymphoblastoid cell lines: B95-8 and Raji, after EBV lytic cycle induction.
benmansour Riadh +4 more
doaj +2 more sources
Bortezomib promotes KHSV and EBV lytic cycle by activating JNK and autophagy. [PDF]
Sci Rep, 2017 KSHV and EBV are gammaherpesviruses strictly linked to human cancers. Even if the majority of cancer cells harbor a latent infection, the few cells that undergo viral replication may contribute to the pathogenesis and maintenance of the virus-associated ...
Granato M +7 more
europepmc +4 more sources
The activation of KSHV lytic cycle blocks autophagy in PEL cells [PDF]
Autophagy, 2015 This study confirms that autophagy is activated concomitantly with KSHV lytic cycle induction, and that autophagy inhibition by BECN1 knockdown reduces viral lytic gene expression.
CIRONE, Mara +7 more
core +4 more sources
Differential Carbonic Anhydrase Activities Control EBV-Induced B-Cell Transformation and Lytic Cycle Reactivation [PDF]
, 2023 Malik S +8 more
europepmc +2 more sources
Viruses, 2019 Phage lytic enzymes are enzymes produced by bacterial viruses, either as part of their virion to facilitate bacterial infection through local peptidoglycan degradation, or as soluble proteins to induce massive cell lysis at the end of the lytic ...
Yves Briers
doaj +3 more sources