Results 21 to 30 of about 100,112 (246)

EBV Exploits RNA m6A Modification to Promote Cell Survival and Progeny Virus Production During Lytic Cycle [PDF]

Frontiers in Microbiology, 2022
N6-methyladenosine (m6A) mediates various biological processes by affecting RNA stability, splicing, and translational efficiency. The roles of m6A modification in Epstein-Barr virus (EBV) infection in the lytic phase are unclear.
Yusuke Yanagi, Takahiro Watanabe, Yuya Hara, Yoshitaka Sato, Hiroshi Kimura, Takayuki Murata, Takayuki Murata   +6 more
doaj   +2 more sources

Phage lytic enzymes [PDF]

Viruses, 2019
Phage lytic enzymes are enzymes produced by bacterial viruses, either as part of their virion to facilitate bacterial infection through local peptidoglycan degradation, or as soluble proteins to induce massive cell lysis at the end of the lytic ...
Briers, Yves
core   +3 more sources

Spatial Model for Oncolytic Virotherapy with Lytic Cycle Delay [PDF]

Bulletin of Mathematical Biology, 2019
We formulate a mathematical model of functional partial differential equations for oncolytic virotherapy which incorporates virus diffusivity, tumor cell diffusion, and the viral lytic cycle based on a basic oncolytic virus dynamics model. We conduct a detailed analysis for the dynamics of the model and carry out numerical simulations to demonstrate ...
Jianjun Paul Tian, Jianjun Paul Tian, Jiantao Zhao   +2 more
openaire   +5 more sources

Single cell expression and chromatin accessibility of the Toxoplasma gondii lytic cycle identifies AP2XII-8 as an essential ribosome regulon driver [PDF]

Nature Communications
Sequential lytic cycles driven by cascading transcriptional waves underlie pathogenesis in the apicomplexan parasite Toxoplasma gondii. This parasite’s unique division by internal budding, short cell cycle, and jumbled up classically defined cell cycle ...
Jingjing Lou, Yasaman Rezvani, Argenis Arriojas, Yihan Wu, Nachiket Shankar, David Degras, Caroline D. Keroack, Manoj T. Duraisingh, Kourosh Zarringhalam, Marc-Jan Gubbels   +9 more
doaj   +2 more sources

Experimental Dissection of the Lytic Replication Cycles of Herpes Simplex Viruses in vitro [PDF]

Frontiers in Microbiology, 2018
Herpes simplex viruses type 1 and type 2 (HSV-1 and HSV-2) produce lifelong infections and are highly prevalent in the human population. Both viruses elicit numerous clinical manifestations and produce mild-to-severe diseases that affect the skin, eyes, and brain, among others. Despite the existence of numerous antivirals against HSV, such as acyclovir
Francisco Javier Muñoz Ibáñez, Mónica A. Farías, Maria P. Gonzalez-Troncoso, Nicolás Corrales, Luisa F. Duarte, Angello Retamal‐Díaz, Pablo A. González   +6 more
openalex   +6 more sources

Lytic Cycle of Toxoplasma gondii: 15 Years Later [PDF]

Annual Review of Microbiology, 2015
Toxoplasmosis is the clinical and pathological consequence of acute infection with the obligate intracellular apicomplexan parasite Toxoplasma gondii. Symptoms result from tissue destruction that accompanies lytic parasite growth. This review updates current understanding of the host cell invasion, parasite replication, and eventual egress that ...
Ira J. Blader, Bradley I. Coleman, Chun-Ti Chen, Marc-Jan Gubbels   +3 more
openaire   +4 more sources

Cyclin-Dependent Kinase Activity Controls the Onset of the HCMV Lytic Cycle

PLoS Pathogens, 2010
The onset of human cytomegalovirus (HCMV) lytic infection is strictly synchronized with the host cell cycle. Infected G0/G1 cells support viral immediate early (IE) gene expression and proceed to the G1/S boundary where they finally arrest. In contrast, S/G2 cells can be infected but effectively block IE gene expression and this inhibition is not ...
Martin Zydek, Christian Hagemeier, Lüder Wiebusch   +2 more
openalex   +6 more sources

The FIKK kinase of Toxoplasma gondii is not essential for the parasite’s lytic cycle [PDF]

International Journal for Parasitology, 2016
FIKK kinases are a novel family of kinases unique to the Apicomplexa. While most apicomplexans encode a single FIKK kinase, Plasmodium falciparum expresses 21 and piroplasms do not encode a FIKK kinase. FIKK kinases share a conserved C-terminal catalytic domain, but the N-terminal region is highly variable and contains no known functional domains.
Corey E. Gaylets, Dana G. Mordue, Nathaniel Kim, Ali A. Sultan, Klemens Engelberg, Marc-Jan Gubbels, Brian Lynch, Odaelys Walwyn, Sini Skariah   +8 more
openaire   +4 more sources

Calcium signaling and the lytic cycle of the Apicomplexan parasite Toxoplasma gondii [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2018
Toxoplasma gondii has a complex life cycle involving different hosts and is dependent on fast responses, as the parasite reacts to changing environmental conditions. T. gondii causes disease by lysing the host cells that it infects and it does this by reiterating its lytic cycle, which consists of host cell invasion, replication inside the host cell ...
Silvia N.J. Moreno, Miryam Andrea Hortua Triana, Karla M. Márquez-Nogueras, Stephen A. Vella   +3 more
openaire   +4 more sources

Rapid metabolic reprogramming mediated by the AMP-activated protein kinase during the lytic cycle of Toxoplasma gondii [PDF]

Nat Commun, 2023
Yaqiong Li, Zhipeng Niu, Jichao Yang, Xuke Yang, Yukun Chen, Yingying Li, Xiaohan Liang, Jingwen Zhang, Fuqiang Fan, Ping Wu, Chao Peng, Bang Shen   +11 more
openalex   +2 more sources