Results 101 to 110 of about 146,884 (299)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Prochaine séance de l'Atelier "Genre et Médias" le Jeudi 12 Mars 2015

open access: yes, 2015
La prochaine séance de l'Atelier "Genre et Médias" aura lieu le Jeudi 12 Mars 2015 de 17h à 19h Nous aurons le plaisir d'écouter Véra Léon " Etudier le devenir photographe sous le prisme du genre (1945-1975). Enjeux, sources, méthodes.
Genre et Médias
core  

Amours et aventures de Sindbad le marin, de Salim Bachi, un roman postmoderne ?

open access: yesLangues & Cultures
Le présent article analyse la dimension postmoderne du roman Amours et aventures de sindbad le marin de Salim Bachi. Il s’agit de démontrer comment se manifeste une pensée critique à l’égard de la modernité, notamment occidentale, qui autorise, à ...
Rim MOULOUDJ
doaj  

Economia terciária nas cidades médias do estado do Ceará, Brasil: evolução e concentração [PDF]

open access: diamond, 2020
Walas Wedel Martins de Santana   +4 more
openalex   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Patrimoine – Images-Médias – Identités

open access: yes, 2016
Le projet Patrimoines-Images-Médias-Identités (PIMI) s’attache, à partir d’une démarche comparative à l’analyse du paysage audiovisuel du Brésil et de la France.
Évelyne Cohen
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

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