Results 61 to 70 of about 567,812 (303)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Le racisme à la péruvienne : contradictions et ambigüité de la notion de cholo
L'Ordinaire des Amériques, 2008 L’Indien qui migre vers la ville et devient urbain est appelé cholo ; il acquiert une identité métisse, mouvante, antagonique. Le racisme au Pérou s’exerce depuis longtemps contre les populations indigènes, mais la façon dont il se répand parmi les ...
Emilie Doré, Carmen María Sandoval
doaj +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Comment prendre en compte les spécificités de "l'écriture SMS" pour l'analyse de sentiments ? [PDF]
, 2016 Avec la croissance explosive des données textuelles issues des médias sociaux (forums, blogs et réseaux sociaux), l'exploitation de ces nouvelles sources d'information est devenue cruciale.
Bouhafs Hafsia, Asma +2 more
core
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Las industrias culturales y de información: un enfoque socioeconómico
Revista Electrónica de Investigación Educativa, 2008 Este artículo revisa la discusión que inició en la década de los setenta sobre las relaciones entre los fenómenos de comunicación e información, y las decisiones del ámbito económico. Esta discusión, como lo afirma Miège, ha sido abordada desde distintos
Bernard Miège
doaj
, 2015 International audienceL'objectif de cette communication serait effectivement de s'interroger voire d'analyser les causes de la pérennité de certains acteurs et la disparition des autres.
Amamou, Leila
core +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Vers une modélisation de l'agenda géomédiatique international : distribution spatiale, temporelle et médiatique des flux d'actualité à travers le monde [PDF]
, 2016 International audienceNotre image du monde dépend dans une large mesure des flux d'information que nous recevons de l'étranger via les médias de masse.
Grasland, Claude +3 more
core +2 more sources