Results 141 to 150 of about 18,955 (175)

PEA3 Transcription Factors, Role in Invasion, Proliferation and Radioresistance of Glioblastoma Stem Cells. [PDF]

J Cell Mol Med
Nicaise Y, Delmas C, Cohen-Jonathan-Moyal E, Seva C.   +3 more
europepmc   +1 more source

Atypical Presentation of Hereditary Sensory and Autonomic Neuropathy Type IIB: A Family of HSAN IIB With Spasticity Presentation and Review on Sensory Neuropathies With Spasticity

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT A 10‐year‐old boy from a consanguineous family presented with progressive lower‐limb spasticity and a family history of painless, non‐healing trophic ulcers of the lower limbs. Genetic testing identified a homozygous FAM134B mutation, confirming HSAN IIB and expanding its clinical spectrum with early pyramidal involvement.
Farzad Ahmadabadi, Marzieh Babaee, Narjes Jafari, Mohadeseh Fathi, Diba Akbarzadeh, Amin Jazayeri   +5 more
wiley   +1 more source

Brain tumoroids: Treatment prediction and drug development for brain tumors with fast, reproducible, and easy-to-use personalized models. [PDF]

Neuro Oncol
Soubéran A, Jiguet-Jiglaire C, Toutain S, Morando P, Baeza-Kallee N, Appay R, Boucard C, Graillon T, Meyer M, Farah K, Figarella-Branger D, Tabouret E, Tchoghandjian A.   +12 more
europepmc   +1 more source

KDM4B Knockdown Attenuates Neurological Deficits in Ischemic Stroke by Inhibiting Neuronal Apoptosis Associated With Birc5 Upregulation

CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
In ischemic stroke, knockdown of the histone demethylase KDM4B was associated with Birc5 upregulation, a key member of the inhibitor of apoptosis protein (IAP) family. This was further associated with increased Bcl‐2 expression, decreased Bax expression, and reduced activation of initiator caspases (caspase‐8/9) and effector caspases (caspase‐3/6/7 ...
Siyu Deng, Nueraili Maihemuti, Mengjie Jia, Keli Huang, Mao Xie, Qi He, Jing Zhao   +6 more
wiley   +1 more source

The microbiome and brain metastasis in non‐small cell lung cancer: A graded appraisal and a framework for prevention‐oriented research

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
This Review proposes a microbiome–premetastatic brain niche axis connecting gut, lung, and intratumoral microbes with metabolites, blood–brain barrier remodeling, neuroimmune priming, and brain metastasis in NSCLC. It integrates current evidence while distinguishing established mechanisms from associations and hypotheses requiring prospective and ...
Long Liang, Fangjuan Hu, Xiaofeng Wang, Chunhan Tang, Chun Wang, Gefei Jiang, Chungang Zhao, Yin Zhang, Churong Li   +8 more
wiley   +1 more source

Refractory Retroperitoneal Abscess Caused by Hypermucoviscous Klebsiella pneumoniae Requiring Open Surgical Drainage

IJU Case Reports, Volume 9, Issue 6, November 2026.
ABSTRACT Introduction Klebsiella pneumoniae is broadly classified into classical and hypervirulent pathotypes, with the latter associated with invasive infections and hematogenous dissemination. Case Presentation An 89‐year‐old woman presented with fever and fatigue. Imaging revealed a large retroperitoneal abscess.
Shota Kikuchi, Yoshihiro Nakagami, Kanji Hirota, Takuya Yashima, Toshiki Mugita, Sho Okada, Motoki Yamagishi, Masakazu Nagata, Kazuhiko Oshinomi, Takashi Fukagai   +9 more
wiley   +1 more source

An epidemiology report for primary central nervous system tumors in adolescents and young adults: a nationwide population-based study in France, 2008-2013. [PDF]

Neuro Oncol, 2020
Ng S, Zouaoui S, Bessaoud F, Rigau V, Roux A, Darlix A, Bauchet F, Mathieu-Daudé H, Trétarre B, Figarella-Branger D, Pallud J, Frappaz D, Roujeau T, Bauchet L.   +13 more
europepmc   +1 more source

Pan‐Cancer Landscape of TMEM9 With Experimental Validation in Head and Neck Squamous Cell Carcinoma

The Journal of Gene Medicine, Volume 28, Issue 11, November 2026.
Transmembrane protein 9 (TMEM9) was investigated across cancers using public transcriptomic, clinical, genomic, and immune datasets, followed by functional validation in head and neck squamous cell carcinoma (HNSC). TMEM9 showed cancer‐dependent expression, diagnostic discrimination, prognostic associations, and relationships with immune infiltration ...
Mi Wang, Shangyan Ying, Chunyan Weng, Youfeng Li   +3 more
wiley   +1 more source

Efficacy and Safety of ramucirumab Combined With Nab‐paclitaxel, Lobaplatin, and S‐1 in Conversion Therapy for Unresectable Advanced Gastric Cancer: Preliminary Results of Conversion Therapy Cohort of RNPLS‐01 Trial

MedComm, Volume 7, Issue 11, November 2026.
This study enrolled 70 HER2‐negative, unresectable stage III/IV gastric/gastroesophageal junction adenocarcinoma patients with over 6‐month survival, divided into RNPLS and NPLS groups (n = 35 each). Both groups received 21‐day‐cycle chemotherapy with lobaplatin, nab‐paclitaxel, and S‐1, while RNPLS additionally used ramucirumab.
Juan Wang, Wei Wang, Guanghui Xu, Shushang Liu, Longxing Jiao, Shu Wang, Chaosheng Peng, Yuxuan Ma, Xin Liu, Huade Huo, Haolin Li, Xiaohua Li, Jianjun Yang   +12 more
wiley   +1 more source

Alzheimer's Disease: Mechanisms and Therapeutic Advances

MedComm, Volume 7, Issue 11, November 2026.
Alzheimer's disease involves Aβ/tau aggregation, neuroinflammation, BBB leakage, gut–brain dysfunction, and mitochondrial damage, causing neuronal loss. Nanodelivery enables combined small‐molecule and targeted therapies. Disease‐modifying biologics/chemicals, including anti‐Aβ antibodies, raise safety and access concerns. Exercise, cognitive training,
Gaoshuang Fu, Mingmin Pan, Qingling Sun, Guangxin Yue, Tong Lei   +4 more
wiley   +1 more source