Results 111 to 120 of about 12,489,240 (294)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

open access: yesFEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang   +5 more
wiley   +1 more source

El punt de vista en la narrativa: el desenrotllament d'un concepte crític / [PDF]

open access: yes, 1975
Repàs als diversos punts de vista: l'omnisciència editorial, l'omnisciència neutral, el "jo" com a testimoni, el "jo" com a protagonista, l'omnisciència múltiple i ...
Friedman, Norman
core   +1 more source

Safety profile and practical considerations of monoclonal antibody treatment

open access: yesNeurología (English Edition), 2013
Introduction: Monoclonal antibodies (mAb) are immunoglobulins specially designed to act against specific targets, in such a way that their administration stops a specific pathogenic process, stimulates a particular cellular action, or changes a cell ...
B. Casanova Estruch
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

open access: yesFEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Fisiologia Vegetal. Qüestionaris [PDF]

open access: yes, 2008
Es tracta de qüestions de fisiologia vegetal, principalment en format d'elecció múltiple, dirigides a fixar i reforçar els coneixements de l'assignatura en estudiants de ciències ...
Picazo González, Isabel   +1 more
core  

Ecological and evolutionary facets of biodiversity. The Second Interdisciplinary Symposium, 28-30 September 2017, Cluj-Napoca, Romania

open access: yesStudia Universitatis Babeș-Bolyai. Biologia, 2017
Ecological and evolutionary facets of biodiversity. The Second Interdisciplinary Symposium, 28-30 September 2017, Cluj-Napoca, Romania.
multiple authors
doaj  

Molecular bases of circadian magnesium rhythms across eukaryotes

open access: yesFEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

USO DE BORTEZOMIB, TALIDOMIDA Y DEXAMETASONA, COMO TERAPIA DE PRIMERA LÍNEA EN PACIENTES CON MIELOMA MÚLTIPLE DE RECIENTE DIAGNÓSTICO. CENTRO MÉDICO ISSEMYM. ARTURO MONTIEL ROJAS [PDF]

open access: yes, 2013
El Mieloma Múltiple (MM) es una neoplasia maligna hematológica caracterizada por una proliferación clonal no controlada de células plasmáticas, las cuales producen una paraproteína monoclonal.
Albarrán Segura, Marco Ulises   +2 more
core  

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

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