IFN-γ +874 T/A Is Associated with High Levels of Sera CPK in Patients with Inflammatory Myopathies [PDF]
Current Issues in Molecular BiologyAim of the study: Idiopathic inflammatory myopathies (IIM) are autoimmune diseases with a low prevalence and incidence worldwide. The levels of IFN-γ production by T-lymphocytes are related to disease activity.
Mónica Vázquez-Del Mercado +3 more
doaj +2 more sources
PTGDR -441 C/T Polymorphism in a Mexican Mestizo Population with Inflammatory Myopathies: A Pilot Study [PDF]
Current Issues in Molecular BiologyThe prostaglandin D2 receptor (PTGDR) -441 C/T polymorphism has been previously associated with inflammatory diseases such as asthma. The goal of this study was to explore the association of this polymorphism with idiopathic inflammatory myopathies (IIM)
Mónica Vázquez-Del Mercado +3 more
doaj +2 more sources
Cardiovascular risk scores, non-invasive vascular measures and myositis damage index reveal increased cardiovascular risk in idiopathic inflammatory myopathies: a case-control study [PDF]
BMC RheumatologyBackground Data about cardiovascular risk (CVR) in idiopathic inflammatory myopathies (IIM) may not be fully captured by traditional scores. This case-control study evaluated cardiovascular disease (CVD) risk through non-invasive tools in IIM patients ...
Gabriela Paola Garcia-Ordoñez +8 more
doaj +2 more sources
Preliminary ultrastructural analysis suggests phenotype-specific myofiber alterations in idiopathic inflammatory myopathies [PDF]
Scientific ReportsIdiopathic inflammatory myopathies (IIM) comprise a heterogeneous group of autoimmune muscle diseases with variable patterns of muscle damage. In this multicentric cross-sectional study, we employed scanning electron microscopy (SEM) to characterize ...
Andrea Aguilar-Vazquez +24 more
doaj +2 more sources
Treinamento Físico Reduz a Inflamação e a Fibrose e Preserva a Função e a Perfusão Miocárdica em um Modelo de Cardiomiopatia Chagásica Crônica [PDF]
Arquivos Brasileiros de CardiologiaResumo Fundamento: A Cardiomiopatia Chagásica Crônica (CCC) é causada por um processo inflamatório induzido pelo Trypanosoma cruzi, que leva à miocardite com fibrose reativa e reparativa.
Thayrine R. Damasceno +14 more
doaj +2 more sources
Equine Veterinary Journal, Volume 55, Issue 4, Page 618-631, July 2023., 2023 Abstract Background Both type 1 (PSSM1) and type 2 polysaccharide storage myopathy (PSSM2) are characterised by aggregates of abnormal polysaccharide in skeletal muscle. Whereas the genetic basis for PSSM1 is known (R309H GYS1), the cause of PSSM2 in Quarter Horses (PSSM2‐QH) is unknown and glycogen concentrations not defined.
Stephanie J. Valberg +7 more
wiley +1 more source
Computed tomography findings in horses presented with signs of head‐shaking
Equine Veterinary Journal, Volume 55, Issue 4, Page 649-655, July 2023., 2023 Abstract Background Trigeminal nerve‐mediated head‐shaking (TNMH) in horses is a diagnosis made by exclusion. Computed tomography (CT) is frequently used to identify any disease process that could cause the clinical signs of head‐shaking. Although abnormalities are frequently identified, it is unknown whether treatment of these conditions improves ...
Melanie Perrier +2 more
wiley +1 more source
Effects of Etanercept on TNF‐α Inhibition in Rats with Adenine‐Induced Chronic Kidney Disease
BioMed Research International, Volume 2022, Issue 1, 2022., 2022 Introduction. Chronic kidney disease (CKD) constitutes a chronic inflammatory state associated with an increase in inflammatory mediators and profibrotic molecules such as tumor necrosis factor‐α (TNF‐α). Etanercept (ETA) is a TNF inhibitor widely used in treatment of autoimmune inflammatory diseases.
Edgar Mendieta-Condado +7 more
wiley +1 more source
Impaired muscle strength is associated with ultrastructure damage in myositis
Scientific Reports, 2022 The muscle fiber ultrastructure in Idiopathic Inflammatory Myopathies (IIM) has been scarcely explored, especially in Inclusion Body Myositis. The aim of this study was to implement the Scanning Electron Microscopy (SEM) in a small cohort of IIM patients,
Andrea Aguilar-Vazquez +20 more
doaj +1 more source
Biomolecules, 2023 Osteopontin (OPN) is a bone-derived phosphoglycoprotein related to physiological and pathological mechanisms that nowadays has gained relevance due to its role in the immune system response to chronic degenerative diseases, including rheumatoid arthritis
Beatriz Teresita Martín-Márquez +8 more
doaj +1 more source