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The ‐174G/C Interleukin‐6 Gene Promoter Polymorphism as a Genetic Marker of Differences in Therapeutic Response to Methotrexate and Leflunomide in Rheumatoid Arthritis

BioMed Research International, Volume 2016, Issue 1, 2016., 2016
Objective. To evaluate the association of ‐174G/C IL-6 polymorphism with failure in therapeutic response to methotrexate (MTX) or leflunomide (LEF). This prospective, observational cohort included 96 Mexican‐Mestizo patients with moderate or severe rheumatoid arthritis (RA), initiating MTX or LEF, genotyped for IL-6 ‐174G/C polymorphism by PCR‐RFLP ...
A. J. Ruiz-Padilla +15 more
wiley +1 more source

CCL2 Serum Levels and Adiposity Are Associated with the Polymorphic Phenotypes ‐2518A on CCL2 and 64ILE on CCR2 in a Mexican Population with Insulin Resistance

Journal of Diabetes Research, Volume 2016, Issue 1, 2016., 2016
Genetic susceptibility has been described in insulin resistance (IR). Chemokine (C‐C motif) ligand‐2 (CCL2) is overexpressed in white adipose tissue and is the ligand of C‐C motif receptor‐2 (CCR2). The CCL2 G‐2518A polymorphism is known to regulate gene expression, whereas the physiological effects of the CCR2Val64Ile polymorphism are unknown. The aim
Milton-Omar Guzmán-Ornelas +10 more
wiley +1 more source

Low CD36 and LOX‐1 Levels and CD36 Gene Subexpression Are Associated with Metabolic Dysregulation in Older Individuals with Abdominal Obesity

Journal of Diabetes Research, Volume 2016, Issue 1, 2016., 2016
Background. Obesity study in the context of scavenger receptors has been linked to atherosclerosis. CD36 and LOX‐1 are important, since they have been associated with atherogenic and metabolic disease but not fat redistribution. The aim of our study was to determinate the association between CD36 and LOX‐1 in presence of age and abdominal obesity ...
Perla-Monserrat Madrigal-Ruíz +10 more
wiley +1 more source

Symposium 10: Insulin and exercise signaling cascade in skeletal muscle

Revista de la Sociedad Argentina de Diabetes, 2022
The skeletal striated muscle is one of the main tissues capable of regulating glycemia, increasing glucose transport by both insulin stimulation and physical exercise.
Martín Pavarotti
doaj +1 more source

The 482Ser of PPARGC1A and 12Pro of PPARG2 Alleles Are Associated with Reduction of Metabolic Risk Factors Even Obesity in a Mexican‐Mestizo Population

BioMed Research International, Volume 2015, Issue 1, 2015., 2015
The aim of this study was to investigate the relationship between functional polymorphisms Gly482Ser in PPARGC1A and Pro12Ala in PPARG2 with the presence of obesity and metabolic risk factors. We included 375 individuals characterized as Mexican‐Mestizos and classified by the body mass index (BMI).
Mónica Vázquez-Del Mercado +8 more
wiley +1 more source

Serum Levels of Anticyclic Citrullinated Peptide Antibodies, Interleukin‐6, Tumor Necrosis Factor‐α, and C‐Reactive Protein Are Associated with Increased Carotid Intima‐Media Thickness: A Cross‐Sectional Analysis of a Cohort of Rheumatoid Arthritis Patients without Cardiovascular Risk Factors

BioMed Research International, Volume 2015, Issue 1, 2015., 2015
The main cause of death in rheumatoid arthritis (RA) is cardiovascular events. We evaluated the relationship of anticyclic citrullinated peptide (anti‐CCP) antibody levels with increased carotid intima‐media thickness (cIMT) in RA patients. Methods. Forty‐five anti‐CCP positive and 37 anti‐CCP negative RA patients, and 62 healthy controls (HC) were ...
Mónica Vázquez-Del Mercado +14 more
wiley +1 more source

The Impact of LEP G‐2548A and LEPR Gln223Arg Polymorphisms on Adiposity, Leptin, and Leptin‐Receptor Serum Levels in a Mexican Mestizo Population

BioMed Research International, Volume 2015, Issue 1, 2015., 2015
The polymorphisms in leptin (LEP G‐2548A) and leptin‐receptor (LEPR Gln223Arg) seem to influence obesity and lipid metabolism among others. The aim of this study was to investigate the effect of these polymorphisms on adiposity, leptin (sLeptin), and leptin‐receptor (sLeptin‐receptor) serum concentrations as well as inflammation markers.
Efraín Chavarria-Avila +8 more
wiley +1 more source

Low Levels of CD36 in Peripheral Blood Monocytes in Subclinical Atherosclerosis in Rheumatoid Arthritis: A Cross‐Sectional Study in a Mexican Population

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
Patients with rheumatoid arthritis (RA) have a higher risk for atherosclerosis. There is no clinical information about scavenger receptor CD36 and the development of subclinical atherosclerosis in patients with RA. The aim of this study was to evaluate the association between membrane expression of CD36 in peripheral blood mononuclear cells (PBMC) and ...
Eduardo Gómez-Bañuelos +14 more
wiley +1 more source

Dolor músculo esquelético y factores asociados en una empresa de servicios públicos

Revista Colombiana de Salud Ocupacional, 2014
Objetivo: Determinar la prevalencia en el último año de dolor músculo esquelético y los factores asociados en los trabajadores de esta empresa. Metodología: Estudio descriptivo, transversal, correlacional en una población de 240 trabajadores ...
Diego F. Gómez- Vélez, Oscar E. Leal-Terranova +1 more
doaj +1 more source

Cascada de señalización de la insulina y la actividad física para el transporte de GLUT-4 y la captación de glucosa en el músculo esquelético

Revista de la Sociedad Argentina de Diabetes, 2023
El músculo esquelético (ME), debido a su significativo tamaño y función, representa el tejido que más energía demanda durante la actividad física. En respuesta a esta demanda, ha desarrollado un sistema altamente especializado para almacenar energía y ...
Martín Alejandro Pavarotti, Martín Rodríguez +1 more
doaj +1 more source

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