Results 151 to 160 of about 596,037 (247)

Correction: Structure-based design of an aromatic helical foldamer-protein interface. [PDF]

open access: yesChem Sci
Wang L   +10 more
europepmc   +1 more source

Health Care Provider Perceptions of Screening for Early‐Stage Type 1 Diabetes—A Survey Study

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To evaluate the feasibility, perceived benefits, and challenges of integrating early‐stage Type 1 diabetes screening and monitoring into routine care. Materials and Methods Primary health care providers (HCPs; n = 683), responsible for collecting capillary blood samples and obtaining informed consent, and specialised diabetes centres (n = 
Claire Cherdron   +11 more
wiley   +1 more source

In memoriam † Prof. Dr. Volker Fahlbusch [PDF]

open access: yes, 2009
Göhlich, U. B.   +3 more
core   +1 more source

Closed‐Form Optimal Investment Under Generalized GARCH Models

open access: yesEuropean Financial Management, EarlyView.
ABSTRACT This paper introduces a new class of stochastic volatility models for asset prices, the generalized Heston Nandi GARCH (GHN‐GARCH), with the primary objective of optimal dynamic asset allocation under expected utility theory for constant relative risk aversion investors. We study some of its theoretical properties, and demonstrate that the GHN‐
Marcos Escobar‐Anel   +2 more
wiley   +1 more source

Ligand‐specific tuning of CLEC10A signalling strength and dendritic cell responses through engagement of different GalNAc‐containing glycan structures

open access: yesThe FEBS Journal, EarlyView.
The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs   +7 more
wiley   +1 more source

Spatially resolved mapping of histones reveals selective neuronal response in Rett syndrome

open access: yesThe FEBS Journal, EarlyView.
Loss of Mecp2 function is associated with Rett syndrome (RTT). MeCP2 regulates chromatin, yet its influence on histone composition and dynamics is unclear. Combining MALDI‐MSI with LCM–LC–MS/MS, we mapped histone proteoforms across the dentate gyrus, cornu ammonis, and cerebellum in two mouse models of RTT.
Frederike Schäfer   +6 more
wiley   +1 more source

Integrative Metabolomics of Targeted and Nontargeted Analyses in T2D Progression. [PDF]

open access: yesDiabetes Care
Ge J   +16 more
europepmc   +1 more source

Fast & fuelious: the malate–aspartate shuttle in brown adipocyte lipid metabolism

open access: yesThe FEBS Journal, EarlyView.
Brown adipose tissue (BAT) produces heat in response to cold exposure, for which it relies on the coordination of aerobic and anaerobic metabolism. However, how reaction intermediates connect these two essential pathways is unclear. In this issue of The FEBS Journal, Veliova et al., report that the malate–aspartate shuttle (MAS) supports norepinephrine‐
Lukas Blaas, Alexander Bartelt
wiley   +1 more source

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