A new functional assay reveals that membrane binding is critical for overactivation of the phosphoinositide 3-kinase H1047R mutant. [PDF]
Papafotika A +10 more
europepmc +1 more source
DNA‐Enzyme Hybrid Nanostructures: Functional Materials to Modulate Enzymatic Activity
DNA–enzyme hybrid nanostructures enable precise spatial and stoichiometric control over enzyme organization, offering a powerful platform to modulate catalytic activity. This review critically evaluates key mechanistic hypotheses, including proximity effects, microenvironment changes, confinement, and stabilization, as well as highlighting ...
Manar Elnaggar, Amelie Heuer‐Jungemann
wiley +1 more source
Determination of Antioxidant, Antidiabetic, Anticholinergic, Antiglaucoma Properties and Comprehensive Phytochemical Content by LC-MS/MS of Bingöl Honeybee Pollen. [PDF]
İzol E +4 more
europepmc +1 more source
Porous Organic Polymers: From Molecular Design to Scalable Technologies
This review introduces porous organic polymers (POPs) for a wide range of applications, including energy storage, gas adsorption, catalysts, adsorbents, biomedical applications, sensors, and other exciting fields, and critically analyzes the synthesis and modification, and how structural topology influences the composites' architecture of POPs, along ...
Hossein Mashhadimoslem +12 more
wiley +1 more source
The fusion subunit vaccine L-DBF protects aged mice against heterologous lethal <i>Shigella</i> challenge after prior exposure. [PDF]
Parvej MS +9 more
europepmc +1 more source
Recent Advances in Photocatalyst‐Driven Protein Labeling and Proximity Mapping
Photocatalyst‐driven protein labeling and proximity mapping have rapidly advanced as powerful strategies for spatiotemporal control in complex biological environments. This review integrates recent developments across single‐electron transfer and energy transfer‐based mechanisms and highlights how catalyst design, reactive intermediates, and diffusion ...
Shinichi Sato +3 more
wiley +1 more source
Chronology of H3N2 human influenza virus surface glycoprotein adaptation from 1968 to 2019 reveals a surge of adaptation between 1997 and 2002. [PDF]
Lei H +9 more
europepmc +1 more source
Genetically Engineered Filamentous Bacteriophages Displaying TGF-β1 Promote Angiogenesis in 3D Microenvironments. [PDF]
Baek IH, Helms V, Kim Y.
europepmc +1 more source
Substrate‐specific mitochondrial dysfunction and metabolomic profiles in type 2 diabetic rat hearts
Abstract Type 2 diabetes (T2D) greatly alters cardiac fuel handling, yet how mitochondrial function adapts to the diabetic substrate environment remains unclear. This study investigated substrate‐specific cardiac mitochondrial bioenergetics from a T2D rat model induced by a high‐fat diet and low‐dose streptozotocin.
Toan Pham
wiley +1 more source
High-pressure activation for the solvent- and catalyst-free syntheses of heterocycles, pharmaceuticals and esters. [PDF]
Plasse K +5 more
europepmc +1 more source

