Results 91 to 100 of about 33,363,096 (232)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
SoftCtrlDC-M: Embedded control software for brushed direct current motors
SoftwareXSoftCtrlDC-M is a control software designed to facilitate the development of a direct current (DC) motor driver by implementing core control code utilizing proportional (P) and integral (I) gains. At the same time, the P gain is dynamically updated using
José A. Niembro-Ceceña +2 more
doaj +1 more source
High-Resolution Underway Upper Ocean and Surface Atmospheric Observations in Drake Passage: Synergistic Measurements for Climate Science [PDF]
Oceanography, 2012 This article highlights recent and ongoing studies that analyze in situ underway upper ocean and surface atmospheric observations from frequently repeated transects by the Antarctic Research and Supply Vessel Laurence M. Gould in Drake Passage.
Janet Sprintall +2 more
doaj
Kv12.1 channels are not sensitive to GqPCR-triggered activation of phospholipase Cβ
Channels, 2018 Kv12.1 K+ channels are expressed in several brain areas, but no physiological function could be attributed to these subunits so far. As genetically-modified animal models are not available, identification of native Kv12.1 currents must rely on ...
Marlen Dierich, Michael G. Leitner
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source