Activation of Peripheral KCNQ Channels Attenuates Inflammatory Pain [PDF]
Molecular Pain, 2014 Background: Refractory chronic pain dramatically reduces the quality of life of patients. Existing drugs cannot fully achieve effective chronic pain control because of their lower efficacy and/or accompanying side effects.
Hiroki Hayashi +2 more
exaly +5 more sources
Drosophila KCNQ channel displays evolutionarily conserved electrophysiology and pharmacology with mammalian KCNQ channels. [PDF]
PLoS ONE, 2011 Of the five human KCNQ (Kv7) channels, KCNQ1 with auxiliary subunit KCNE1 mediates the native cardiac I(Ks) current with mutations causing short and long QT cardiac arrhythmias. KCNQ4 mutations cause deafness.
Sonia Cavaliere, James J L Hodge
doaj +8 more sources
KCNQ potassium channels modulate Wnt activity in gastro-oesophageal adenocarcinomas [PDF]
Life Science Alliance, 2023 KCNQ3, a potassium channel, is frequently genetically altered in gastro-oesophageal adenocarcinomas and found to be significantly associated with WNT and MYC activity, and cellular proliferation.
David Shorthouse +10 more
doaj +5 more sources
K(V)7/KCNQ channels are functionally expressed in oligodendrocyte progenitor cells. [PDF]
PLoS ONE, 2011 BACKGROUND: K(V)7/KCNQ channels are widely expressed in neurons and they have multiple important functions, including control of excitability, spike afterpotentials, adaptation, and theta resonance.
Wei Wang +4 more
doaj +2 more sources
Postnatal reduction of eIF4E overexpression in D1-SPNs ameliorates KCNQ channel dysfunction, hyperexcitability and ASD-like behaviours [PDF]
Cellular and Molecular Life SciencesAn imbalance between the direct and indirect pathways of the striatum has been linked to the pathophysiology of autism spectrum disorder (ASD), manifesting as repetitive behaviours and hyperactivity.
Alina Aaltonen +4 more
doaj +2 more sources
Involvement of sphingosine-1-phosphate receptor 1 in pain insensitivity in a BTBR mouse model of autism spectrum disorder [PDF]
BMC MedicineBackground Abnormal sensory perception, particularly pain insensitivity (PAI), is a typical symptom of autism spectrum disorder (ASD). Despite the role of myelin metabolism in the regulation of pain perception, the mechanisms underlying ASD-related PAI ...
Lili Fan +11 more
doaj +2 more sources
Kcnq (Kv7) channels exhibit frequency-dependent responses via partial inductor-like gating dynamics [PDF]
Communications BiologyKcnq channels are low-threshold voltage-dependent K+ channels that generate M-currents, which regulate the peri-threshold membrane potential. Kcnq channels reportedly participate in band-pass frequency responses (i.e., resonance), but it remains largely ...
Yuta Eguchi +4 more
doaj +2 more sources
Involvement of HDAC2-mediated kcnq2/kcnq3 genes transcription repression activated by EREG/EGFR-ERK-Runx1 signaling in bone cancer pain [PDF]
Cell Communication and SignalingBone cancer pain (BCP) represents a prevalent symptom among cancer patients with bone metastases, yet its underlying mechanisms remain elusive. This study investigated the transcriptional regulation mechanism of Kv7(KCNQ)/M potassium channels in DRG ...
Zi-Xian Zhang +6 more
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Presynaptic Mechanisms and KCNQ Potassium Channels Modulate Opioid Depression of Respiratory Drive
Frontiers in Physiology, 2019 Opioid-induced respiratory depression (OIRD) is the major cause of death associated with opioid analgesics and drugs of abuse, but the underlying cellular and molecular mechanisms remain poorly understood.
Jan-Marino Ramirez, Aguan Wei
exaly +3 more sources
Frontiers in Physiology, 2021 The pre-Bötzinger complex (preBötC) of the ventral medulla generates the mammalian inspiratory breathing rhythm. When isolated in explants and deprived of synaptic inhibition, the preBötC continues to generate inspiratory-related rhythm.
Ann L. Revill +10 more
doaj +1 more source