Results 41 to 50 of about 3,925 (184)
The contribution of Kv7 channels to pregnant mouse and human myometrial contractility. [PDF]
, 2011 Premature birth accounts for approximately 75% of neonatal mortality and morbidity in the developed world. Despite this, methods for identifying and treating women at risk of preterm labour are limited and many women still present in preterm labour ...
Pierce, SL +9 more
core +1 more source
Rapid activity-dependent modulation of the intrinsic excitability through up-regulation of KCNQ/Kv7 channel function in neonatal spinal motoneurons. [PDF]
PLoS ONE, 2018 Activity-dependent changes in the properties of the motor system underlie the necessary adjustments in its responsiveness on the basis of the environmental and developmental demands of the organism.
Joseph Lombardo +2 more
doaj +1 more source
The variable phenotypes of
Epilepsia, 2014 SummaryMutations in KCNQ2 and KCNQ3 were originally described in infants with benign familial neonatal seizures (BFNS). Recently, KCNQ2 mutations have also been shown to cause epileptic encephalopathy. This report describes three infants carrying abnormalities of KCNQ2 and one infant with a KCNQ3 mutation.
Nicholas M, Allen +6 more
openaire +2 more sources
Age-dependent electrical and morphological remodeling of the Drosophila heart caused by hERG/seizure mutations. [PDF]
PLoS Genetics, 2017 Understanding the cellular-molecular substrates of heart disease is key to the development of cardiac specific therapies and to the prevention of off-target effects by non-cardiac targeted drugs.
Karen Ocorr +7 more
doaj +1 more source
Potassium channels (including KCNQ) and epilepsy [PDF]
Epilepsia, 2010 SummaryPotassium channels are integral to neuronal excitability. They set the resting membrane potential and shape depolarizations caused by excitatory synaptic inputs and action potentials. One potassium channel subgroup—alternatively called the KCNQ, Kv7, or M‐channels—has recently emerged as a viable target for antiepileptic drugs.
openaire +1 more source
Molecular Pain, 2015 Background Hyperexcitability of nociceptive afferent fibers is an underlying mechanism of neuropathic pain and ion channels involved in neuronal excitability are potentially therapeutic targets.
Alaa A Abd-Elsayed +6 more
doaj +1 more source
Neurobiology of Disease, 2013 In models of temporal lobe epilepsy, in-vitro exposure of the entorhinal cortex (EC) to low concentrations of acetylcholine (ACh) induces muscarinic-dependent seizure-like events.
Anna Maslarova +5 more
doaj +1 more source
Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates. [PDF]
PLoS Genetics, 2008 In many mammalian neurons, dense clusters of ion channels at the axonal initial segment and nodes of Ranvier underlie action potential generation and rapid conduction.
Alexis S Hill +7 more
doaj +1 more source
Frontiers in Behavioral Neuroscience, 2015 The medial prefrontal cortex (mPFC) is a key brain region for the control of consummatory behavior. Neuronal activity in this area is modulated when rats initiate consummatory licking and reversible inactivations eliminate reward contrast effects and ...
Marc Alexander Parent +4 more
doaj +1 more source
KCNQ channel opening as a powerful mechanism for vasodilation [PDF]
, 2011 KCNQ channels were recently found in the vascular system. We have tested the hypothesis that KCNQ channels are powerful targets for relaxation of small systemic and pulmonary arteries.
Zhuravleva, Nadezda (gnd: 1027084400)
core +1 more source