Results 21 to 30 of about 3,925 (184)

KCNQs: Ligand- and Voltage-Gated Potassium Channels [PDF]

Frontiers in Physiology, 2020
Voltage-gated potassium (Kv) channels in the KCNQ (Kv7) family are essential features of a broad range of excitable and non-excitable cell types and are found in organisms ranging from Hydra vulgaris to Homo sapiens.
Geoffrey W. Abbott
doaj   +5 more sources

Neuronal KCNQ potassium channels:physislogy and role in disease

Nature Reviews Neuroscience, 2000
Humans have over 70 potassium channel genes, but only some of these have been linked to disease. In this respect, the KCNQ family of potassium channels is exceptional: mutations in four out of five KCNQ genes underlie diseases including cardiac arrhythmias, deafness and epilepsy.
Jentsch, T.J., Thomas J. Jentsch
openaire   +3 more sources

Elucidation of the zinc binding site in KCNQ channels [PDF]

British Journal of Pharmacology
Background and Purpose KCNQ1‐5 (Kv7.1–7.5) are members of a family of voltage‐gated potassium channels with prominent function in the nervous and cardiovascular systems and in epithelia. KCNQ channels are activated by intracellular free zinc, but the molecular mechanism of this effect is poorly understood and ...
Zhang, S., Yang, X., Yang, M., Cao, Y., Shi, S., Gamper, N., Gao, H.   +6 more
openaire   +4 more sources

The role of KCNQ channels in the thalamus

, 2013
Der ventrobasale thalamische Komplex (VB) spielt eine entscheidende Rolle bei der somatosensorischen Informationsverarbeitung und ist insbesondere wichtig für die diskriminativen und räumlichen Aspekte der akuten Schmerzverarbeitung. Wir schlagen einen neuen antinozizeptiven Mechanismus vor, der auf der Aktivierung von KCNQ-Kanälen in diesem Hirngebiet
Cerina, M. (Manuela)
core   +3 more sources

KCNQ potassium channels: physiology, pathophysiology, and pharmacology

Pharmacology & Therapeutics, 2001
KCNQ genes encode a growing family of six transmembrane domains, single pore-loop, K(+) channel alpha-subunits that have a wide range of physiological correlates. KCNQ1 (KvLTQ1) is co-assembled with the product of the KCNE1 (minimal K(+)-channel protein) gene in the heart to form a cardiac-delayed rectifier-like K(+) current.
Robbins, J
core   +4 more sources

K_v7 and K_2P Potassium Channels in Thalamocortical Function and Their Therapeutic Potential in Childhood Absence Epilepsy. [PDF]

Arch Pharm (Weinheim)
Modulation of K2P and Kv7 channels has the potential to reduce hyperexcitability and hypersynchronicity within the thalamocortical system. This offers a new avenue to suppress spike and wave discharges, the electrophysiological hallmark of absence epilepsy.
Takhi A, Seebohm G, Budde T, Lüttjohann A.   +3 more
europepmc   +2 more sources

Could NAPQI Contribute to Paracetamol Analgesia? Redox Modulation of Kv7 Ion Channels. [PDF]

Pharmacol Res Perspect
ABSTRACT Paracetamol (acetaminophen, APAP) is one of the most widely used analgesic and antipyretic drugs worldwide, yet its mechanism of action remains incompletely understood. While several pathways have been proposed, including cyclooxygenase inhibition and endocannabinoid modulation via AM404, none fully account for its pharmacological profile. The
M-Alicante S, Urrutia J, Muguruza-Montero A, Revuelta M, Arrizabalaga-Iriondo A, Villarroel A, Nuñez E.   +6 more
europepmc   +2 more sources

NeuralKCNQ(Kv7) channels [PDF]

British Journal of Pharmacology, 2009
KCNQgenes encode five Kv7 K+channel subunits (Kv7.1–Kv7.5). Four of these (Kv7.2–Kv7.5) are expressed in the nervous system. Kv7.2 and Kv7.3 are the principal molecular components of the slow voltage‐gated M‐channel, which widely regulates neuronal excitability, although other subunits may contribute to M‐like currents in some locations. M‐channels are
David A, Brown, Gayle M, Passmore
openaire   +2 more sources

Regulation of KCNQ channels by manipulation of phosphoinositides [PDF]

The Journal of Physiology, 2007
Activation of phospholipase C (PLC) through G‐protein‐coupled receptors produces a large number of second messengers and regulates many physiological processes. Many membrane proteins including ion channels require the phosphoinositide phosphatidylinositol 4,5‐bisphosphate (PIP2) to function.
Byung-Chang, Suh, Bertil, Hille
openaire   +2 more sources

SMITten for KCNQ Channels [PDF]

Biophysical Journal, 2017
Over the last two decades, members of the KCNQ channel family of potassium channels (KCNQ1–5) have emerged as critical regulators of cardiac and neuronal excitability (1,2). KCNQ1 channels are the molecular determinants of the cardiac slow potassium current, IKS (1), which is partly responsible for the repolarization of the cardiac action potential ...
openaire   +2 more sources