Behavior of KCNQ Channels in Neural Plasticity and Motor Disorders [PDF]
Membranes, 2022 The broad distribution of voltage-gated potassium channels (VGKCs) in the human body makes them a critical component for the study of physiological and pathological function.
Xiang-Ping Chu
exaly +5 more sources
KCNQ channels regulate age-related memory impairment. [PDF]
PLoS ONE, 2013 In humans KCNQ2/3 heteromeric channels form an M-current that acts as a brake on neuronal excitability, with mutations causing a form of epilepsy. The M-current has been shown to be a key regulator of neuronal plasticity underlying associative memory and
Sonia Cavaliere +2 more
doaj +4 more sources
Paclitaxel Inhibits KCNQ Channels in Primary Sensory Neurons to Initiate the Development of Painful Peripheral Neuropathy [PDF]
Cells, 2022 Cancer patients undergoing paclitaxel infusion usually experience peripheral nerve degeneration and serious neuropathic pain termed paclitaxel-induced peripheral neuropathy (PIPN).
Qing Yang, Danny Dang, Gabor Toro
exaly +4 more sources
K(V)7/KCNQ channels are functionally expressed in oligodendrocyte progenitor cells. [PDF]
PLoS ONE, 2011 BACKGROUND: K(V)7/KCNQ channels are widely expressed in neurons and they have multiple important functions, including control of excitability, spike afterpotentials, adaptation, and theta resonance.
Wei Wang +4 more
doaj +3 more sources
Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability [PDF]
Frontiers in Behavioral Neuroscience, 2015 The medial prefrontal cortex (mPFC) is a key brain region for the control of consummatory behavior. Neuronal activity in this area is modulated when rats initiate consummatory licking and reversible inactivations eliminate reward contrast effects and ...
Marc Alexander Parent +4 more
doaj +2 more sources
KCNQ channels show conserved ethanol block and function in ethanol behaviour. [PDF]
PLoS ONE, 2012 In humans, KCNQ2/3 channels form an M-current that regulates neuronal excitability, with mutations in these channels causing benign neonatal familial convulsions. The M-current is important in mechanisms of neural plasticity underlying associative memory
Sonia Cavaliere +2 more
doaj +2 more sources
KCNQ Channels in Nociceptive Cold-Sensing Trigeminal Ganglion Neurons as Therapeutic Targets for Treating Orofacial Cold Hyperalgesia [PDF]
Molecular Pain, 2015 Background Hyperexcitability of nociceptive afferent fibers is an underlying mechanism of neuropathic pain and ion channels involved in neuronal excitability are potentially therapeutic targets.
Alaa A Abd-Elsayed +6 more
doaj +2 more sources
PIP2 regulation of KCNQ channels: biophysical and molecular mechanisms for lipid modulation of voltage-dependent gating [PDF]
Frontiers in Physiology, 2014 Voltage-gated potassium (Kv) channels contain voltage-sensing (VSD) and pore-gate (PGD) structural domains. During voltage-dependent gating, conformational changes in the two domains are coupled giving rise to voltage-dependent opening of the channel. In
Mark Alan Zaydman, Jianmin eCui
doaj +2 more sources
K<sub>v</sub>7 and K<sub>2P</sub> Potassium Channels in Thalamocortical Function and Their Therapeutic Potential in Childhood Absence Epilepsy. [PDF]
Arch Pharm (Weinheim)Modulation of K2P and Kv7 channels has the potential to reduce hyperexcitability and hypersynchronicity within the thalamocortical system. This offers a new avenue to suppress spike and wave discharges, the electrophysiological hallmark of absence epilepsy.
Takhi A +3 more
europepmc +2 more sources
Activation of Peripheral KCNQ Channels Attenuates Inflammatory Pain [PDF]
Molecular Pain, 2014 Background: Refractory chronic pain dramatically reduces the quality of life of patients. Existing drugs cannot fully achieve effective chronic pain control because of their lower efficacy and/or accompanying side effects.
Hiroki Hayashi +3 more
doaj +2 more sources