Results 11 to 20 of about 800,175 (138)
Pulmonary vasoconstrictor action of KCNQ potassium channel blockers [PDF]
Respiratory Research, 2006 Background KCNQ channels have been widely studied in the nervous system, heart and inner ear, where they have important physiological functions. Recent reports indicate that KCNQ channels may also be expressed in portal vein where they are suggested to ...
Balan Prabhu +2 more
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Drosophila KCNQ channel displays evolutionarily conserved electrophysiology and pharmacology with mammalian KCNQ channels. [PDF]
PLoS ONE, 2011 Of the five human KCNQ (Kv7) channels, KCNQ1 with auxiliary subunit KCNE1 mediates the native cardiac I(Ks) current with mutations causing short and long QT cardiac arrhythmias. KCNQ4 mutations cause deafness.
Sonia Cavaliere, James J L Hodge
doaj +3 more sources
Centipedes subdue giant prey by blocking KCNQ channels [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2018 Centipedes can subdue giant prey by using venom, which is metabolically expensive to synthesize and thus used frugally through efficiently disrupting essential physiological systems.
Ping Liang, Ming Zhou, Xiaochen Wang
exaly +3 more sources
Functional effects of KCNQ K+ channels in airway smooth muscle [PDF]
Frontiers in Physiology, 2013 KCNQ (Kv7) channels underlie a voltage-gated K+ current best known for control of neuronal excitability, and its inhibition by Gq/11-coupled, muscarinic signaling. Studies have indicated expression of KCNQ channels in airway smooth muscle (ASM), a tissue
Alexey I Evseev +7 more
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KCNQ potassium channels modulate Wnt activity in gastro-oesophageal adenocarcinomas [PDF]
Life Science Alliance, 2023 KCNQ3, a potassium channel, is frequently genetically altered in gastro-oesophageal adenocarcinomas and found to be significantly associated with WNT and MYC activity, and cellular proliferation.
David Shorthouse +10 more
doaj +6 more sources
Regions of KCNQ K+ Channels Controlling Functional Expression [PDF]
Frontiers in Physiology, 2012 KCNQ1-5 α-subunits assemble to form K+ channels that play critical roles in the function of numerous tissues. The channels are tetramers of subunits containing six transmembrane domains.
Frank eChoveau, Mark S Shapiro
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Could NAPQI Contribute to Paracetamol Analgesia? Redox Modulation of Kv7 Ion Channels. [PDF]
Pharmacol Res PerspectABSTRACT Paracetamol (acetaminophen, APAP) is one of the most widely used analgesic and antipyretic drugs worldwide, yet its mechanism of action remains incompletely understood. While several pathways have been proposed, including cyclooxygenase inhibition and endocannabinoid modulation via AM404, none fully account for its pharmacological profile. The
M-Alicante S +6 more
europepmc +2 more sources
Neurobiology of Disease, 2013 In models of temporal lobe epilepsy, in-vitro exposure of the entorhinal cortex (EC) to low concentrations of acetylcholine (ACh) induces muscarinic-dependent seizure-like events.
Anna Maslarova +2 more
exaly +3 more sources
Kcnq (Kv7) channels exhibit frequency-dependent responses via partial inductor-like gating dynamics [PDF]
Communications BiologyKcnq channels are low-threshold voltage-dependent K+ channels that generate M-currents, which regulate the peri-threshold membrane potential. Kcnq channels reportedly participate in band-pass frequency responses (i.e., resonance), but it remains largely ...
Yuta Eguchi +4 more
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Frontiers in Physiology, 2021 The pre-Bötzinger complex (preBötC) of the ventral medulla generates the mammalian inspiratory breathing rhythm. When isolated in explants and deprived of synaptic inhibition, the preBötC continues to generate inspiratory-related rhythm.
Ann L. Revill +10 more
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