Results 11 to 20 of about 3,925 (184)
A change in configuration of the calmodulin-KCNQ channel complex underlies Ca2+-dependent modulation of KCNQ channel activity. [PDF]
PLoS ONE, 2013 All subtypes of KCNQ channel subunits (KCNQ1-5) require calmodulin as a co-factor for functional channels. It has been demonstrated that calmodulin plays a critical role in KCNQ channel trafficking as well as calcium-mediated current modulation. However,
Anastasia Kosenko, Naoto Hoshi
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KCNQ channels regulate age-related memory impairment. [PDF]
PLoS ONE, 2013 In humans KCNQ2/3 heteromeric channels form an M-current that acts as a brake on neuronal excitability, with mutations causing a form of epilepsy. The M-current has been shown to be a key regulator of neuronal plasticity underlying associative memory and
Sonia Cavaliere +2 more
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Behavior of KCNQ Channels in Neural Plasticity and Motor Disorders
Membranes, 2022 The broad distribution of voltage-gated potassium channels (VGKCs) in the human body makes them a critical component for the study of physiological and pathological function.
Som P. Singh +3 more
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Regions of KCNQ K+ Channels Controlling Functional Expression [PDF]
Frontiers in Physiology, 2012 KCNQ1-5 α-subunits assemble to form K+ channels that play critical roles in the function of numerous tissues. The channels are tetramers of subunits containing six transmembrane domains.
Frank eChoveau, Mark S Shapiro
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Pulmonary vasoconstrictor action of KCNQ potassium channel blockers [PDF]
Respiratory Research, 2006 Background KCNQ channels have been widely studied in the nervous system, heart and inner ear, where they have important physiological functions. Recent reports indicate that KCNQ channels may also be expressed in portal vein where they are suggested to ...
Balan Prabhu +2 more
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Functional effects of KCNQ K+ channels in airway smooth muscle [PDF]
Frontiers in Physiology, 2013 KCNQ (Kv7) channels underlie a voltage-gated K+ current best known for control of neuronal excitability, and its inhibition by Gq/11-coupled, muscarinic signaling. Studies have indicated expression of KCNQ channels in airway smooth muscle (ASM), a tissue
Alexey I Evseev +7 more
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, 2023 KCNQ channels, also known as Kv7 channels, are a diverse group of K+ channels that exhibit a wide variety of properties and perform various physiological functions in the body. This family comprises five members, Kv7.1-7.5. These channels exhibit unusual
Anastasios V. Tzingounis +1 more
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KCNQ Modulators Reveal a Key Role for KCNQ Potassium Channels in Regulating the Tone of Rat Pulmonary Artery Smooth Muscle [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2009 Potassium channels are central to the regulation of pulmonary vascular tone. The smooth muscle cells of pulmonary artery display a background K(+) conductance with biophysical properties resembling those of KCNQ (K(V)7) potassium channels. Therefore, we investigated the expression and functional role of KCNQ channels in pulmonary artery. The effects of
Joshi, Shreena +4 more
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Protein arginine methylation facilitates KCNQ channel-PIP2 interaction leading to seizure suppression [PDF]
eLife, 2016 KCNQ channels are critical determinants of neuronal excitability, thus emerging as a novel target of anti-epileptic drugs. To date, the mechanisms of KCNQ channel modulation have been mostly characterized to be inhibitory via Gq-coupled receptors, Ca2 ...
Hyun-Ji Kim +21 more
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KCNQ channels show conserved ethanol block and function in ethanol behaviour. [PDF]
PLoS ONE, 2012 In humans, KCNQ2/3 channels form an M-current that regulates neuronal excitability, with mutations in these channels causing benign neonatal familial convulsions. The M-current is important in mechanisms of neural plasticity underlying associative memory
Sonia Cavaliere +2 more
doaj +2 more sources