Results 161 to 170 of about 28,693,335 (281)

A Chiral Virus‐Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy

Advanced Science, EarlyView.
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu, Xuting Zheng, Huinan Tong, Ying Liu, Xiaoxi Fan, Miao Xu, Ziyan Zhang, Li Zhang, Mingyan Liu, Ting Du, Heran Li, Guojun Liu   +11 more
wiley   +1 more source

BRCA1 Mutation‐Recognizing Tetrahedral Framework Nucleic Acid Nanoplatform Enables Coordinated PARP/WEE1 Inhibition and STING‐Associated Antitumor Immunity in Ovarian Cancer

Advanced Science, EarlyView.
BRCA1 mutation‐responsive FBOA‐tFNA selectively recognizes mutant transcripts and coordinates reduction‐responsive intracellular delivery of olaparib and adavosertib, amplifying DNA damage and weakening G2/M checkpoint protection. These effects are accompanied by STING‐associated immune activation and stronger antitumor immunity, while sequential anti ...
Chenyi Wang, Mengying Yao, Jinhui Xie, Dingjie Wang, Yashi Shi, Xiaodan Mao, Chunhua Lu, Pengming Sun   +7 more
wiley   +1 more source

Reln mRNA Delivery Drives Neurogenic Bone Regeneration by Orchestrating Schwann Cell‐Mediated Exosomal Trafficking

Advanced Science, EarlyView.
MSNs serve as a robust vehicle for CRISPRa‐mediated Reln induction, driving bone repair through the establishment of a neurogenic‐supportive microenvironment. ABSTRACT Neurogenic bone regeneration is essential for the effective restoration of bone tissue functionality, while the mechanisms and new strategies underlying neurogenic bone regeneration ...
Shuai Lin, Qianwen Li, Duo Liu, Mingzhao Li, Han Zhang, Liujing Chen, Yan Yu, Jiuhui Jiang, Chun Xu, Ruili Yang   +9 more
wiley   +1 more source

A Mechanistic Dissection of Multifaceted Complement Attack in Age‐Related Macular Degeneration Reveals the Superiority of C3 Inhibition

Advanced Science, EarlyView.
Complement‐mediated RPE degeneration extends beyond terminal MAC injury. A four‐hit mechanism emerges in which C3a and C5a disrupt mitochondrial function, while C3b and MAC compromise the phagolysosomal system. Upstream C3 inhibition suppresses this full spectrum of pathogenic effectors, providing broader cellular protection than C5 blockade.
Zhidong Chen, Mingshuang Wang, Huiqin Liu, Feng Qian   +3 more
wiley   +1 more source

Electrocatalytic Urea Synthesis From CO2 and N2/NO3−: Bridging Catalyst Activity, C–N Coupling Kinetics, and Industrial Applicability

Advanced Science, EarlyView.
This review compares NO3− + CO2 and N2 + CO2 electrocatalytic urea synthesis in feedstock properties, catalyst design, C–N coupling mechanisms, performance optimization, and engineering applicability. The two systems correspond to a near‐term deployable route and a long‐term green synthesis goal, respectively.
Fulin Dong, Ruihan Zhang, Huiyu Lou, Tianshi Gao, Guangjin Zhang, Menglei Yuan   +5 more
wiley   +1 more source

SensEnhance: A Genetic Circuit for Converting Endogenous Mammalian Gene Signals Into High‐Dynamic‐Range Genetic Readouts

Advanced Science, EarlyView.
Here, we present SensEnhance, a modular genetic circuit that converts leaky, low‐dynamic‐range promoter signals into tightly controlled, high‐dynamic‐range outputs. Applied to mechanosensing and IL‐6‐responsive promoters, SensEnhance increases fold changes from 2.6‐ and 2.5‐fold in promoter‐only configurations to over 20‐ and 14‐fold, respectively ...
Miguel Baños, Stanislav Anastassov, Payman Goodarzi, Mustafa Khammash, Wilfried Weber   +4 more
wiley   +1 more source

A Single‐Capillary Open Microfluidic Probe for Robust and Versatile Spatial Multi‐Omics Using Ambient Mass Spectrometry Imaging

Advanced Science, EarlyView.
This study reports a knot‐shaped single‐capillary open microfluidic probe (Knot‐probe) for robust and versatile spatial omics, enabling ambient mass spectrometry imaging with high spatial resolution, throughput, and structure‐resolved capability. Knot‐probe mitigates the trade‐off between analytical performance and operational robustness, providing an ...
Xiangyu Zhu, Yunkai Li, Jianing Wang, Chengyi Xie, Lei Guo, Yanyan Chen, Thomas Ka‐Yam Lam, Shao‐Wen Shi, Kun Wang, Baoliang Chen, Zongwei Cai   +10 more
wiley   +1 more source

Obstructive Hypertrophic Cardiomyopathy With Degenerative Mitral Regurgitation: A New Treatment Strategy Using Mavacamten Combined With M-TEER. [PDF]

JACC Case Rep
Wang Y, Liu X, Ma L, Liu Y, Cao Y, An G, Liu F, Dong M.   +7 more
europepmc   +1 more source

Ligand‐Ratio–Tuned DNA Nanocarriers Overcome Bladder Barriers for Ultralow‐Dose Intravesical Therapy

Advanced Science, EarlyView.
A programmable DNA framework drug carrier coordinates barrier transport, tumor targeting, and drug delivery through ligand‐ratio engineering. Systematic exploration of the Sgc8/fluorocarbon design space reveals a nonlinear optimal balance between penetration and cellular engagement, translating multifunctional integration into durable bladder tumor ...
Dunfang Liu, Xiao Chen, Hongliang Bao, Qian Xia, Gang Huang, Yang Yang   +5 more
wiley   +1 more source

A Compact Resistively Loaded Metamaterial Absorber for 2.4 GHz RF Energy Harvesting With Impedance‐Matched Rectifier Analysis

Advanced Electronic Materials, EarlyView.
A compact resistively loaded metamaterial absorber captures RF energy at 2.4 GHz and directs most of the accepted power to modeled loads. The resonant response is confirmed experimentally for the fabricated absorber, while an impedance‐matched rectifier is evaluated through simulation. The stage‐wise results distinguish absorber, rectifier, and cascade
Md. Murad Kabir Nipun, Md. Jahedul Islam
wiley   +1 more source