Results 141 to 150 of about 28,693,335 (281)

SAV1 in Cooperation With FKBP52 Participates in Implantation

Advanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan   +10 more
wiley   +1 more source

Isocyanate‐Modified Melatplatin(IV) Enhances Antitumor Efficacy via TCF4/COL6A3‐Mediated Extracellular Matrix Remodeling and cGAS‐STING Pathway Activation in Bladder Cancer

Advanced Science, EarlyView.
A series of melatonin‐conjugated platinum(IV) prodrugs was functionalized with isocyanate chains (compounds 5‒12). MP‐12C (compound 11) was identified as the lead candidate, with optimal potency and safety. MP‐12C exhibited greater efficacy than cisplatin by increasing intracellular uptake, reshaping the extracellular matrix, activating the cGAS‐STING ...
Linhui Wang, Xiaomeng Liu, Tao Zhu, Zirun Su, Ruiping Liu, Zhe Li, Kaixuan Du, Kaipeng Jia, Chong Fu, Yuda Lin, Zihan Xue, Zhe Zhang, Chong Shen, Yunkai Qie, Zhouliang Wu, Zhiheng Liu, Kangkang Liu, Jingyuan Xu, Hailong Hu   +18 more
wiley   +1 more source

Barlow’s Transcatheter Edge-to-Edge Repair in Mitral Annular Calcification

JACC: Case Reports
Objective: The presence of Barlow’s and mitral annular calcification poses significant challenges in mitral transcatheter edge-to-edge repair (M-TEER). Our case involved a patient with both pathologies who underwent successful 3-dimensional intracardiac ...
Leo Kar Lok Lai, MD, Hussayn Alrayes, DO, Georgi Fram, MD, James C. Lee, MD, John Dawdy, MD, Brian P. O’Neill, MD, Tiberio M. Frisoli, MD, Pedro Engel Gonzalez, MD, William W. O’Neill, MD, Pedro A. Villablanca, MD   +9 more
doaj   +1 more source

Persistent Severe Tricuspid Regurgitation After Mitral Transcatheter Edge-to-Edge Repair: Prognostic Implications of Guideline-Based Eligibility for Transcatheter Tricuspid Valve Intervention

Structural Heart
Background: Persistent tricuspid regurgitation (TR) after mitral transcatheter edge-to-edge repair (M-TEER) is common and associated with adverse outcomes.
Moritz Kühlein, MD, Jule Tervooren, Vera Fortmeier, MD, Amelie Hesse, Elena Rippen, MD, Michelle Fett, Héctor Alfonso Alvarez Covarrubias, MD, Moritz von Scheidt, MD, Ferdinand Roski, Muhammed Gerçek, MD, Shinsuke Yuasa, MD, PhD, N. Patrick Mayr, MD, Erion Xhepa, MD, PhD, Karl-Ludwig Laugwitz, MD, Michael Joner, MD, Volker Rudolph, MD, Teresa Trenkwalder, MD, Tobias Rheude, MD, Mark Lachmann, MD   +18 more
doaj   +1 more source

Temporal‐Targeted Accelerated 40 Hz tACS Enhances Cognitive Function and Network Integration in Alzheimer's Disease: A Randomized Clinical Trial

Advanced Science, EarlyView.
Bilateral temporal accelerated 40‐Hz tACS improves cognitive function in patients with Alzheimer's disease. Resting‐state fNIRS identifies treatment‐related increases in frontotemporoparietal functional connectivity, which are associated with cognitive improvement. ABSTRACT The temporal lobes are key hubs for memory and cognition.
Rong Guo, Xingxing Li, Chenjun Zou, Chao Zheng, Xiaohong Wu, Xuechao Lu, Jiaying Yan, Junfang Zhang, Xiaoyan Luo, Shiwei Ye, Dongsheng Zhou   +10 more
wiley   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Multicenter Evaluation of an Edge-to-Edge Repair System in High-Risk Patients With Degenerative Mitral Regurgitation

Structural Heart
Background: Transcatheter edge-to-edge repair (TEER) has become an effective alternative for treating degenerative mitral regurgitation (DMR) in patients at high surgical risk.
Kai Xu, MD, PhD, Junjie Zhang, MD, PhD, Da Zhu, MD, PhD, Yan Wang, MD, PhD, Hong Jiang, MD, PhD, Jing Chen, MD, PhD, Jiyan Chen, MD, PhD, Jiancheng Xiu, MD, PhD, Ben He, MD, PhD, RuiYan Zhang, MD, PhD, Xiaogang Guo, MD, PhD, ChuanYu Gao, MD, PhD, ZhiXiong Zhong, MD, Ping Li, MS, DaJun Chai, MD, PhD, Jun Jin, MD, Yuguo Chen, MD, PhD, Lang Hong, MS, Yida Tang, MD, Guosheng Fu, MD, PhD, Ling Tao, MD, PhD, Yining Yang, MD, PhD, Shenghua Zhou, MD, PhD, Bin Liu, MD, PhD, Lijun Gan, MD, Bo Yu, MD, PhD, Maurizio Taramasso, MD, PhD, Xiangbin Pan, MD, PhD, Shaoliang Chen, MD, PhD, Yaling Han, MD, PhD   +29 more
doaj   +1 more source

25 Pfg // Shampoon mit d. schwarzen Kopf! Mit Teer-Zusatz

25 PFG // SHAMPOON MIT D. SCHWARZEN KOPF! MIT TEER-ZUSATZ 25 Pfg // Shampoon mit d. schwarzen Kopf! Mit Teer-Zusatz ( -

core  

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

Advanced Science, EarlyView.
AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang, Yuan Liu, Huan Peng, Yu Ni, Zhengqiao Jiang, Chenxuan Yu, Xincheng Zhang, Huayu Kang, Yanchao Liu, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Kai Shu, Xiaochuan Wang, Jian‐Zhi Wang, Ting Lei, Chao Gan, Jianfeng Liu, Huaqiu Zhang   +19 more
wiley   +1 more source

Mitral valve transcatheter edge‐to‐edge repair in the elderly—A safe and effective therapy

ESC Heart Failure
Aims Prevalence of mitral regurgitation (MR) and comorbidity burden rise with age. Mitral valve transcatheter edge‐to‐edge repair (M‐TEER) is increasingly performed in elderly patients, but only limited data are available for this specific subgroup.
Dominik Felbel, Michael Paukovitsch, Matthias Gröger, Sinisa Markovic, Leonhard Schneider, Wolfgang Rottbauer, Mirjam Keßler   +6 more
doaj   +1 more source