Results 121 to 130 of about 28,693,335 (281)

A BSCB‐Penetrating Nanoplatform for Enhanced Luteolin Delivery in PRMT2‐Targeted Epigenetic Therapy of Spinal Cord Injury

Advanced Science, EarlyView.
In this work, MSN‐BO@LUT penetrates the blood‐spinal cord barrier for luteolin delivery in spinal cord injury. The nanodrug suppresses neuroinflammation and promotes functional recovery of the spinal cord. Mechanistically, luteolin targets protein arginine N‐methyltransferase (PRMT2) to decrease toll‐like receptor 4 (TLR4) methylation, thereby ...
Yixuan Wang, Bo Jin, Shipian Li, Qianxi Ouyang, Yu Xiao, Jiaxin Wen, Yehua Lai, Ping Wang, Yongjun Wang, Xuejun Cui, Weian Zhang, Min Yao   +11 more
wiley   +1 more source

The Evolving Concept of Secondary Mitral Regurgitation Phenotypes: Lessons From the M-TEER Trials.

JACC. Cardiovascular imaging
Conflicting results from 2 randomized clinical trials of transcatheter mitral valve edge-to-edge repair in secondary mitral regurgitation (SMR) have led to the recognition that SMR is a heterogeneous disease entity presenting with different functional and morphological phenotypes.
Stolz, L, Doldi, PM, Sannino, A, Hausleiter, J, Grayburn, PA, Virmani, R, Achenbach, S, Agricola, E   +7 more
openaire   +2 more sources

The Prognostic Value of Pulmonary Hypertension in Patients with Mitral Regurgitation Undergoing Mitral Valve Transcatheter Edge-to-Edge Repair: A Systematic Review and Meta-Analysis

Diagnostics
Background: Pulmonary hypertension (PH) is associated with the outcomes of mitral valve transcatheter edge-to-edge repair (M-TEER) in patients with severe mitral regurgitation (MR).
Shancuoji, Yanbiao Liao, Junli Li, Mao Chen   +3 more
doaj   +1 more source

PMT from Pasteurella multocida blocks T. b. rhodesiense induced changes in HBMEC TEER.

, 2013
HBMEC grown in 8W10E+ ECIS chambers were incubated with T. b. rhodesiense IL1852. Shown are the changes in real-time TEER measured by ECIS. A) HBMECs incubated with T. b.
Jose C. Garcia-Garcia (262833), Olga V. Nikolskaia (138934), Kevin G. Becker (48792), Carlos A. Pardo (371578), Brenda A. Wilson (237558), J. Stephen Dumler (211426), Ana Paula C. de A. Lima (371580), Yuri V. Kim (371574), Amanda Brown (371577), Yongqing Zhang (49190), Julio Scharfstein (37092), Dennis J. Grab (138957)   +11 more
core   +1 more source

Carbohydrate‐Mediated Cellular Uptake of Boronic Acid Hybrids In Cellulo and Insulin‐Deficient Zebrafish: Live Imaging and Application of Multiphoton FLIM

Advanced Science, EarlyView.
Boronic acid‐based fluorescent hybrids have been used as part of a versatile platform for real‐time metabolic bioimaging across cellular and organismal scales. Including glucose‐responsive imaging in living cells and in an insulin‐deficient vertebrate model, this work opens new opportunities for the development of precision diagnostics, metabolic ...
Haobo Ge, John S. Fossey, David Gonzalez Calatayud, Stephen E. Flower, Sabrina Wang, Hanna Aitessaid, Melita Tvardauskaite, Julia Dudzic, Max Jewell, Charareh Pourzand, Stanley W. Botchway, David Gurevich, Tony D. James, Sofia I. Pascu   +13 more
wiley   +1 more source

Impact of Residual Transmitral Mean Pressure Gradient on Outcomes After Mitral Transcatheter Edge-to-Edge Repair

JACC: Advances
Background: There is conflicting evidence regarding the effect of residual transmitral mean pressure gradient (TMPG) after mitral transcatheter edge-to-edge repair (M-TEER). Different TMPG cutoffs have been employed in prior studies with varying results.
Yasser M. Sammour, MD, MSc, Rody G. Bou Chaaya, MD, Taha Hatab, MD, Syed Zaid, MD, Joe Aoun, MD, Priscilla Wessly, MD, Chloe Kharsa, MD, William A. Zoghbi, MD, Sherif Nagueh, MD, Marvin D. Atkins, MD, Michael J. Reardon, MD, Nadeen Faza, MD, Stephen H. Little, MD, Neal S. Kleiman, MD, Sachin S. Goel, MD   +14 more
doaj   +1 more source

Reparación mitral percutánea de borde a borde en pacientes con antecedente de cáncer: datos del registro español de M-TEER

Introduction and objectives Among cancer survivors, mitral regurgitation (MR) may reflect therapy-related cardiotoxicity or incidental coexistence given the high prevalence of both conditions. We evaluated the efficacy and safety of mitral transcatheter
González Manzanares, Rafael, Carrillo, Xavier, Benito-González, Tomás, Del Trigo, María, Freixa, Xavier, Pan, Manuel, Jiménez-Quevedo, Pilar, Amat Santos, Ignacio J., Carrasco-Chinchilla, Fernando, Cruz-González, Ignacio, Estévez-Loureiro, Rodrigo, Andraka, Leire, Avanzas, Pablo, Nombela-Franco, Luis, Serrador Frutos, Ana M., Díez-Gil, José L., Garrote-Coloma, Carmen, Martínez-Carmona, José D., Ojeda, Soledad, Sanchis, Juan, Pascual, Isaac   +20 more
core   +1 more source

Unlocking Long‐Lived Charge‐Separated State in Pentamethine Cyanine Based on Anionic Hofmeister Effect for Photodynamic Immunotherapy

Advanced Science, EarlyView.
Based on the anionic Hofmeister effect, a universal strategy of incorporation of stereo‐π anion BPh4− into a series of Cy5 skeletons to unlock long‐lived charge‐separated states was reported, wherein the weak electronic coupling and low charge recombination driving force hinder the charge recombination process, elevating the oxygen‐independent ROS ...
Xuan Zhao, Lei Jiang, Yingyong Ni, Ting Wang, Junjun Wang, Shengyu Shi, Jianhua Yu, Zhou Lu, Xiaojiao Zhu, Hongping Zhou   +9 more
wiley   +1 more source

Transcatheter Tricuspid Valve Replacement for Residual Tricuspid Regurgitation After TEER

Background Residual or recurrent tricuspid regurgitation (TR) after prior transcatheter tricuspid edge‐to‐edge (T‐TEER) repair occurs in about 12% of patients within 1 year.
Tobias Zeus, Amin Polzin, Philipp Mourikis, Hanna Kowalski, Malte Kelm, Christian Jung, Patrick Horn, Maximilian Spieker, Richard Truse, Alexander Hoss, Fabian Nienhaus, Artur Lichtenberg, Fabian Voß, Hug Aubin, Jafer Haschemi   +14 more
core   +1 more source

Autonomous Solar Metallurgy for High‐Purity Gold Recovery from Electronic Waste

Advanced Science, EarlyView.
Inspired by microbial strategies for metal uptake and biomineralization, defect‐rich copper sulfide (Cu31S16) functions as a solar metallurgical platform that unifies Au(III) capture, reduction, and self‐separation. The bioinspired design enables ultrafast gold recovery from electronic‐waste leachates and the spontaneous formation of millimeter‐scale ...
Chaopeng Liu, Jiajun Li, Jialin Ruan, Wei Zhang, Wei Sun, Hongmei Li, Lei Xie, Min Liu   +7 more
wiley   +1 more source