Results 101 to 110 of about 22,774,664 (248)

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

LT induces a time- and dose-dependent reduction in TEER.

, 2013
Cells were treated with medium alone (control), 100 ng/ml LF, 500 ng/ml PA, or the combination of 500 ng/ml PA with increasing concentrations of LF. TEER readings were obtained as described in Materials and Methods. Values were reported as the percentage
Matthew C. Williams (405796), Mahtab Moayeri (120194), Jason M. Warfel (405797), Felice D’Agnillo (405795)   +3 more
core   +1 more source

Recent Advances in Carbon Cathode Materials toward High‐Performing Zinc‐Ion Hybrid Supercapacitors

Advanced Science, EarlyView.
Aqueous zinc‐ion hybrid supercapacitors (ZHSCs) have emerged as promising next‐generation electrochemical energy‐storage devices. Porous carbon materials have been extensively studied as cathodes, with advances in tailoring pore structures and material properties to enhance performance.
Take Hirooka, Zhaolin Liu, Ivan P. Parkin, Guanjie He   +3 more
wiley   +1 more source

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Caco-2 cell permeability analysis using transepithelial electrical resistance (TEER).

, 2012
aCaco-2 cells monolayers were grown in transwell inserts and treated with wild type (WT) or Listeria adhesion protein (LAP)-expressing Lb. paracasei for 1, 4, 15, and 24 h, then treated with L. monocytogenes for 2 h. TEER measurements before and after L.
Mary Anne Roshni Amalaradjou (190124), Arun K. Bhunia (190130), Ok Kyung Koo (190118)   +2 more
core   +1 more source

Frequent Sweetened Beverage Consumption Is Associated With Accelerated Biological Aging: Evidence From a Population‐Based Study and Gut Microbiota Analysis

Advanced Science, EarlyView.
Frequent sweetened beverage consumption is associated with accelerated biological aging in a large Chinese population. Five gut microbial genera are consistently enriched in both frequent sweetened beverage consumers and individuals with accelerated aging and show significant mediating effects, suggesting a potential microbiota‐related pathway linking ...
Yuwei Shi, Xinmei Li, Yufan Hao, Qiaoyu Wu, Yuji Yu, Siyu Li, Nuo Xu, Yi‐Hsuan Wu, Eunhye Lee, Chi Chang, Emily Hu, Ying Lu, Elizabeth Delzell, Ann W. Hsing, Shankuan Zhu   +14 more
wiley   +1 more source

Effect of isoflurane and sevoflurane on TEER in vitro.

, 2013
(A) In a monoculture model bEnd.3 cells were exposed for 20 minutes to room air only (airR), airR containing 1.5% of either isoflurane or 3.5% of sevoflurane. After 24 hours TEER values were evaluated.
Clara Luh (294861), Christoph M. Zehendner (294872), Jana Hedrich (254324), Ralph Timaru-Kast (294866), Serge C. Thal (294860), Heiko J. Luhmann (294868), Eva-Verena Schaible (294863), Kristin Engelhard (294870)   +7 more
core   +1 more source

Barlow’s Transcatheter Edge-to-Edge Repair in Mitral Annular Calcification

JACC: Case Reports
Objective: The presence of Barlow’s and mitral annular calcification poses significant challenges in mitral transcatheter edge-to-edge repair (M-TEER). Our case involved a patient with both pathologies who underwent successful 3-dimensional intracardiac ...
Leo Kar Lok Lai, MD, Hussayn Alrayes, DO, Georgi Fram, MD, James C. Lee, MD, John Dawdy, MD, Brian P. O’Neill, MD, Tiberio M. Frisoli, MD, Pedro Engel Gonzalez, MD, William W. O’Neill, MD, Pedro A. Villablanca, MD   +9 more
doaj   +1 more source

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

Persistent Severe Tricuspid Regurgitation After Mitral Transcatheter Edge-to-Edge Repair: Prognostic Implications of Guideline-Based Eligibility for Transcatheter Tricuspid Valve Intervention

Structural Heart
Background: Persistent tricuspid regurgitation (TR) after mitral transcatheter edge-to-edge repair (M-TEER) is common and associated with adverse outcomes.
Moritz Kühlein, MD, Jule Tervooren, Vera Fortmeier, MD, Amelie Hesse, Elena Rippen, MD, Michelle Fett, Héctor Alfonso Alvarez Covarrubias, MD, Moritz von Scheidt, MD, Ferdinand Roski, Muhammed Gerçek, MD, Shinsuke Yuasa, MD, PhD, N. Patrick Mayr, MD, Erion Xhepa, MD, PhD, Karl-Ludwig Laugwitz, MD, Michael Joner, MD, Volker Rudolph, MD, Teresa Trenkwalder, MD, Tobias Rheude, MD, Mark Lachmann, MD   +18 more
doaj   +1 more source