Results 111 to 120 of about 964,507 (280)
M-theory, black holes and cosmology. [PDF]
Kallosh R.
europepmc +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Impact of Majorana fermions on the Kondo state in the carbon nanotube quantum dot
We have studied the quantum conductance of the Kondo state in the carbon nanotube quantum dot (CNTQD) with side-attached multi-Majorana fermion states in topological superconductors (TSCs).
D Krychowski
doaj +1 more source
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Minisuperspace models in M-theory [PDF]
We derive the full canonical formulation of the bosonic sector of 11-dimensional supergravity, and explicitly present the constraint algebra. We then compactify M-theory on a warped product of homogeneous spaces of constant curvature, and construct a minisuperspace of scale factors.
openaire +2 more sources
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
We consider the low energy limit of a stack of N M-branes at finite temperature. In this limit, the M-branes are well described, via the AdS/CFT correspondence, in terms of classical solutions to the eleven dimensional supergravity equations of motion ...
Christopher P Herzog +10 more
core +4 more sources
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
M theory and automorphic scattering [PDF]
12 pages, LaTeX; v2 refs added, typos corr; v3 added comments for ref ...
openaire +2 more sources

