Results 91 to 100 of about 276,178 (242)

Portfolio substitution and the reliability of M1, M2 and M3 as monetary policy indicators [PDF]

Monetary policy - United States ; Money ...
John P. Judd, Bharat Trehan
core  

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza

, 2020
In each influenza season, a distinct group of young, otherwise healthy individuals with no risk factors succumbs to life-threatening infection. To better understand the cause for this, we analyzed a broad range of immune responses in bloodfrom a unique ...
Fernando O Martinez (7065167), Maria Zambon (179437), John McCauley (4724061), Vincenzo Cerundolo (70410), Michael Bennett (41236), Catherine Thomas (4050334), Kambez Hajipouran Benam (9027431), Adel Benlahrech (123879), Lydia Drumright (3339672), Timothy J Powell (9027434), Wendy Barclay (686216), Wai Ling Kok (9027428), Ruth Elderfield (795516), Stephen Taylor (81177), Ling-Pei Ho (346294), Emmanouela Repapi (220397), Foo Y Liew (9027440), MOSAIC investigators (9027437), Tao Dong (15551), Suzanne L Cole (9027425), Peter J Openshaw (9027443), Jake Dunning (3111873), Andrew J McMichael (9027446)   +22 more
core  

Integrated O2 and H2 Gas Therapy via Microneedle‐Assisted Photocatalytic Water Splitting for Accelerating Diabetic Full‐Thickness Skin Wound Healing

Advanced Science, EarlyView.
A concept of integrated O2 and H2 gas therapy is achieved using a gas‐producing material. PMP nanoparticles, fabricated from platinum, MIL‐101(Fe)‐NH2, and phosphotungstic acid, are integrated into bilayer gelatin methacryloyl microneedles for transdermal delivery. These microneedles enable integrated O2 and H2 gas therapy and promote wound healing via
Zesheng Chen, Yanchao Yu, Xingyuan Xiao, Wenwen Cheng, Ye Yang, Zhengyao Zhang, Wang Wang, Zhijun Zhou, Weikang Hu, Xiaolong Wang, Bing Li, Kwang Leong Choy, Yun Chen, Zijian Wang   +13 more
wiley   +1 more source

M1-like and M2-like cell of MPS is verified in public scRNA-seq dataset and human peripheral blood-derived macrophages.

(A). UMAP plot of mononuclear phagocytes in GSE132465 CRC patients. Cells are colored by clusters. (B). Scatterplot showed M1 polarization and M2 polarization score of each cluster in GSE132465 CRC patients.
Jinyun Chen (264711), Shaobo Tian (18056542), Tiantian Ji (12540934), Zheng Wang (25883), Haoyu Fu (1826338), Guobin Wang (322861), Lin Wang (11986), Liping Wang (33601)   +7 more
core   +1 more source

A population-based study of glutathione-S-transferase M1, T1 and P1 genotypes [PDF]

, 2008
A retrospective study on healthy, unrelated subjects was conducted in order to estimate population glutathione-S-transferases (GST) genotype frequencies in Slovak population of men and compare our results with already published data (GSEC project)^1^.
Monika Sivoňová, Tatiana Matáková, Iveta Waczulíková, Peter Račay, Dušan Dobrota, Jozef Hatok, Ján Kliment   +6 more
core  

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

Ears as Portals: Alternative Realities of Musical Infrastructures (A CTM Festival 2023 Review)

Dancecult: Journal of Electronic Dance Music Culture, 2023
Luigi Monteanni
doaj   +1 more source