Results 81 to 90 of about 45,204 (255)

Сценічне втілення естрадної пісні: комплекс виразних засобів у сучасних виконавських практиках

open access: yesВісник Київського національного університету культури і мистецтв. Серія: Музичне мистецтво
Мистецтво естрадного співу охоплює не тільки вокальне мистецтво, а й комплекс виразних засобів, серед яких чільне місце належить акторській майстерності виконавця; міра використання додаткових виразних засобів залежить від індивідуальності виконавця ...
Галина Гаценко   +2 more
doaj   +1 more source

18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis

open access: yesAdvanced Science, EarlyView.
Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan   +11 more
wiley   +1 more source

Development of design specifications for strengthening deteriorated concrete bridge elements using externally applied FRP sheets [PDF]

open access: yes, 2009
El refuerzo a flexión de vigas de hormigón armado con FRP (fibre-reinforced polymer) se ha convertido, en la últimas décadas, en uno de los métodos más utilizados para aumentar la resistencia de una estructura.
Ceci, Alfredo Maria
core  

NIR‐II Imaging‐Guided Photothermal Activation of a TRPV4‐Targeted Nanoplatform Delivering Cycloastragenol to Promote Microglia Reprogramming and α‐Synuclein Clearance in Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo   +9 more
wiley   +1 more source

Ein kritikk av omgrepet «sinfonia», eller korleis Hugo Riemann stal 100 år med norsk symfonihistorie

open access: yesStudia Musicologica Norvegica
Denne artikkelen kritiserer bruken av omgrepet «sinfonia» vis-à-vis «symfoni» i norske tekster. Ein korpusanalyse syner fire ulike og delvis inkompatible meiningar av ordet «sinfonia» er vanlege.
Halvor K. Hosar
doaj   +1 more source

Outline design linkage – road Padna – Sečovlje [PDF]

open access: yes, 2009
The graduation thesis treats the linakge – road Sečovlje – Izola. More exactly it discusses two new alternative ways from Padna to Sečovlje and compares them with the existing route R3- 628/1427 Sečovlje – Dragonja.
Radovac, Jernej
core  

School [PDF]

open access: yes, 2015
Cílem diplomové práce je zpracování projektové dokumentace ve stupni pro provádění stavby. Jedná se o objekt základní školy pro první a druhý stupeň. Dokumentace je zpracována na základě poskytnuté architektonické studie. Objekt je situován na rovinatém,
Filla, Josef
core   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

open access: yesAdvanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong   +8 more
wiley   +1 more source

Nano‐Enabled Systemic Delivery of STING Agonist by Engineered Silicasome for Potent Antitumor Immunotherapy

open access: yesAdvanced Science, EarlyView.
Engineered mesoporous silica nanoparticles (Silicasomes) enable systemic delivery of the STING agonist ADU‐S100, overcoming the instability and toxicity that limit cyclic dinucleotides to local administration. By enhancing tumor accumulation, activating systemic antitumor immunity, and remodeling the tumor immune microenvironment, these nanoparticles ...
Wenjing Zhou   +10 more
wiley   +1 more source

A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation‐Dependent Cell Adhesion

open access: yesAdvanced Science, EarlyView.
Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong   +21 more
wiley   +1 more source

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