Cardioprotective effects of the extracellular chaperone clusterin in acute myocardial infarction
In vivo, CLU−/− mice were more susceptible to acute myocardial infarction than CLU+/+ mice. Moreover, inflammation and histone levels were significantly increased in CLU−/− mice compared to CLU+/+ mice following ischemia/reperfusion. In vitro, CLU protects cardiomyocytes from histone‐ and/or hypoxia‐induced cell death.
Louwana Allawa+12 more
wiley +1 more source
Gender beliefs and legitimization of dating violence in adolescents. [PDF]
Ferreira SB+3 more
europepmc +1 more source
Abstract Objective This study was undertaken to determine how voltage‐gated sodium channel (VGSC) blockers modulate cortical excitability in vivo. VGSCs are critical for regulating axonal excitability, yet the effects of sodium channel‐blocking medications on human cortical neurons remain poorly characterized.
Lorenzo Rocchi+6 more
wiley +1 more source
Regional specialization of movement encoding across the primate sensorimotor cortex. [PDF]
Borgognon S+15 more
europepmc +1 more source
When overexpressed in Staphylococcus aureus, the type I toxins SprA1 and SprA2 form membrane pores, with SprA1 creating stable pores and SprA2 forming transient ones. Both induce concomitant membrane depolarization, ATP release, and growth arrest, while only SprA1 causes membrane permeabilization due to its stable pore formation.
Laurence Fermon+10 more
wiley +1 more source
Ocular surface changes and corneal epithelial remodeling after cataract surgery in patients with type 2 diabetes: a case-control study. [PDF]
Koestel E+4 more
europepmc +1 more source
Abstract Objective Using the fear‐avoidance model (FAM) as a theoretical framework, this study examined the interactions between empirical factors contributing to disability in episodic migraine. It was tested whether pain catastrophizing, fear of attacks, and depressiveness mediate the relationship between pain experience and disability.
Janosch Fox+6 more
wiley +1 more source
Deer Antler Uridine Regulates Glycolysis in Microglia via HSP90/HIF-1α to Improve Cognitive Impairment in Alzheimer's Disease Mice. [PDF]
Liu Y+7 more
europepmc +1 more source
ABSTRACT Introduction Acute leukemias with hyperleukocytosis (> 100 × 109/L) can produce cytoplasmic blast fragments that interfere with platelet counts, notably in impedance‐based methods, potentially masking severe thrombocytopenia and increasing hemorrhagic risk.
Victor Bobée+10 more
wiley +1 more source
Synthesis and Characterization of Cellulose Acetate/Polyethylene Glycol/Poly(Styrene)-b-Poly(4-Vinylpyridine) Membrane Embedded with Hydrotermaly Activated TiO2 Nanoparticles for Waste-Waters Treatment by Membrane Processes. [PDF]
Căprărescu S+7 more
europepmc +1 more source