Results 31 to 40 of about 220,787 (262)

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

A ordem Carmelita The Carmelite order

Per Musi, 2011
O presente estudo enfoca a origem lendária da Ordem Mendicante Carmelita, que remonta ao Antigo Testamento; sua fundação histórica no século XIII, que está profundamente relacionada às experiências maravilhosas (meraviglia), bem como ao seu percurso e ...
Adalgisa Arantes Campos
doaj   +1 more source

Adaptable Covalent Organic Framework‐Hydrogel Microneedles for Glucose‐Responsive Isoliquiritigenin Delivery in Diabetic Wound Therapy

Advanced Healthcare Materials, EarlyView.
We develop a covalent organic framework‐loaded Traditional Chinese Medicine monomer nanodrug delivery system (ISL@bCOF) via boron‐oxygen bonds, a smart response to glucose for delivering AI‐driven isoliquiritigenin (ISL) targeting ZBP1. This dynamic release mechanism, combined with transdermal delivery technology via potent microneedles, can modulate ...
Menghan Zhou, Zongjie Hu, Xiuwen Li, Huaman Geng, Yang Liu, Yajie Wang, Yunshu Yang, Guangdong Zhou, Yujie Hua, Di Wang   +9 more
wiley   +1 more source

Vastidão de os Seis Pequenos Quadros (1981) de Bruno Kiefer: um estudo sobre sua estrutura intervalar, gestos musicais e possíveis relações com outras composições do autor Vastidão [Vastness] of Seis Pequenos Quadros [Six Small Pictures] (1981) by Bruno Kiefer: a study of its intervallic structure, musical gestures and possible relationships with other works by the composer

Per Musi, 2010
O presente trabalho oferece uma análise dos gestos musicais e configurações intervalares da peça intitulada Vastidão, pertencente aos Seis Pequenos Quadros (1981) para piano de Bruno Kiefer.
Germano Gastal Mayer, Any Raquel Carvalho   +1 more
doaj   +1 more source

Table1_Integrated bioinformatic analyses investigate macrophage-M1-related biomarkers and tuberculosis therapeutic drugs.XLSX

, 2023
Tuberculosis (TB) is a common infectious disease linked to host genetics and the innate immune response. It is vital to investigate new molecular mechanisms and efficient biomarkers for Tuberculosis because the pathophysiology of the disease is still ...
Guomin Ye (14584781), Jiangdong Wu (4163053), Weimin Li (131040), Shijie Shen (1722889), Tingting Luo (2744662), Beniamino Terzo Cenci-Goga (14584778), Chuangfu Chen (328590), Saeed El-Ashram (710370), Wanjiang Zhang (5384576), Abdulaziz Alouffi (14584775), Siyuan Li (178640), Siqi Deng (14584772), Keyu Liu (3351053), Hui Zhang (7197), Chengzhang Cao (613701)   +14 more
core   +1 more source

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Image1_Integrated bioinformatic analyses investigate macrophage-M1-related biomarkers and tuberculosis therapeutic drugs.jpg

, 2023
Tuberculosis (TB) is a common infectious disease linked to host genetics and the innate immune response. It is vital to investigate new molecular mechanisms and efficient biomarkers for Tuberculosis because the pathophysiology of the disease is still ...
Guomin Ye (14584781), Jiangdong Wu (4163053), Weimin Li (131040), Shijie Shen (1722889), Tingting Luo (2744662), Beniamino Terzo Cenci-Goga (14584778), Chuangfu Chen (328590), Saeed El-Ashram (710370), Wanjiang Zhang (5384576), Abdulaziz Alouffi (14584775), Siyuan Li (178640), Siqi Deng (14584772), Keyu Liu (3351053), Hui Zhang (7197), Chengzhang Cao (613701)   +14 more
core   +1 more source

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Computational Models of Symbolic Rhythm Similarity: Correlation with Human Judgments [PDF]

Analytical Approaches to World Music, 2011
A novel approach to describing rhythmic relationships in music is introduced by means of three experiments designed to test computational measures of symbolic rhythm similarity against human judgments.
Toussaint, Godfried T., Campbell, Malcolm, Brown, Naor   +2 more
doaj