Results 11 to 20 of about 104,480 (306)

Efficacy and safety of novel multifunctional M10 CAR-T cells in HIV-1-infected patients: a phase I, multicenter, single-arm, open-label study

Cell Discovery
Chimeric antigen receptor T (CAR-T) cells have been proposed for HIV-1 treatment but have not yet demonstrated desirable therapeutic efficacy. Here, we report newly developed anti-HIV-1 CAR-T cells armed with endogenic broadly neutralizing antibodies ...
Yunyu Mao, Qibin Liao, Youwei Zhu, Mingyuan Bi, Jun Zou, Nairong Zheng, Lingyan Zhu, Chen Zhao, Qing Liu, Li Liu, Jun Chen, Ling Gu, Zhuoqun Liu, Xinghao Pan, Ying Xue, Meiqi Feng, Tianlei Ying, Pingyu Zhou, Zhanshuai Wu, Jian Xiao, Renfang Zhang, Jing Leng, Yongtao Sun, Xiaoyan Zhang, Jianqing Xu   +24 more
doaj   +2 more sources

Evaluation of analytical performance of the STANDARDTM M10 MPX/OPX assay for the simultaneous DNA detection and clade attribution of Monkeypox virus

Emerging Microbes and Infections
Monkeypox virus (MPXV) infection confirmation needs reliable polymerase chain reaction (PCR) assays; in addition, viral clade attribution is a key factor in containment measures, considering a more severe syndrome in clade I and the possibility of ...
Alessandro Mancon, Angelo Roberto Raccagni, Gloria Gagliardi, Davide Moschese, Alberto Rizzo, Andrea Giacomelli, Miriam Cutrera, Federica Salari, Fiorenza Bracchitta, Spinello Antinori, Andrea Gori, Giuliano Rizzardini, Antonella Castagna, Maria Rita Gismondo, Silvia Nozza, Davide Mileto   +15 more
doaj   +2 more sources

AAPS Workshop Report on ICH M10 [PDF]

The AAPS Journal, 2019
AbstractOver the last decade, several regulatory guidelines on bioanalytical method validation (BMV) have been issued by regulatory agencies around the world. This has left the bioanalytical community struggling with regional differences in regulatory expectations when preparing for global pharmaceutical submissions.
Booth, Brian, Vazvaei, Faye, Fluhler, Eric, Myler, Heather, Woolf, Eric   +4 more
openaire   +2 more sources

Carbon Isotope Ratios in M10 Giants [PDF]

The Astrophysical Journal, 2019
Abstract We measured carbon abundances and the 12C/13C ratio in 31 giant branch stars with previous CN and CH band measurements that span −2.33 < M V  < 0.18 in the globular cluster M10 (NGC 6254).
Z. G. Maas, J. M. Gerber, Alex Deibel, C. A. Pilachowski   +3 more
openaire   +4 more sources

Induced secondary metabolites of the beneficial fungus Trichoderma harzianum M10 through OSMAC approach

Chemical and Biological Technologies in Agriculture, 2023
Background Fungi biosynthesize a wide range of chemically diverse secondary metabolites during processes of competition with other micro- and macro-organisms, symbiosis, parasitism, or pathogenesis.
Alessia Staropoli, Giuseppina Iacomino, Paola De Cicco, S. Woo, L. D. Di Costanzo, F. Vinale   +5 more
semanticscholar   +1 more source

Comparative Evaluation of a Standard M10 Assay with Xpert Xpress for the Rapid Molecular Diagnosis of SARS-CoV-2, Influenza A/B Virus, and Respiratory Syncytial Virus

Diagnostics, 2023
SARS-CoV-2, influenza A/B virus (IAV/IBV), and respiratory syncytial virus (RSV) are among the common viruses causing acute respiratory infections. Clinical diagnosis to differentiate these viruses is challenging due to similar clinical presentations ...
Azwani Abdullah, I. Sam, Yin Jie Ong, Chun Hao Theo, Muhammad Harith Pukhari, Y. Chan   +5 more
semanticscholar   +1 more source

ICH M10 guideline - a harmonized global approach to bioanalysis

Prospects in Pharmaceutical Sciences, 2023
Bioanalytical methods are used in research on small-molecule and large-molecule drug products to determine analytes and their metabolites in biological matrices such as blood, plasma, serum, urine, feces, saliva, other biological fluids, or tissues ...
Elżbieta Gniazdowska, E. Gilant, Katarzyna Buś-Kwaśnik   +2 more
semanticscholar   +1 more source

Conference Report from the European Bioanalysis Forum Workshop: toward harmonized implementation of the ICH M10 guideline.

Bioanalysis, 2023
In this report, the European Bioanalysis Forum shares the proposals for harmonized implementation of the ICH M10 guideline on bioanalytical method validation and study sample analysis from the ICH M10 workshop.
P. Timmerman, Matthew D. Barfield, Kyra J. Cowan, L. Ferrari, M. Golob, Joanne Goodman, M. Kall, A. Laurén, I. Love, S. Mcdougall, Robert Nelson, Gwenda Pynaert, R. Staack, T. Verhaeghe, Steve White   +14 more
semanticscholar   +1 more source

Microbial Community Analysis in Sichuan South-road Dark Tea Piled Center at Pile-Fermentation Metaphase and Insight Into Organoleptic Quality Development Mediated by Aspergillus niger M10

Frontiers in Microbiology, 2022
Microbes are critical in the Sichuan South-road Dark Tea (SSDT) organoleptic quality development during pile-fermentation. Piled tea center at fermenting metaphase is crucial for the conversion of its quality components.
Y. Zou, Ying Zhang, Yun Tian, Minqiang Liu, Yue Yuan, Yuqing Lai, Xuyi Liu, Wei Xu, L. Tan, Qian Tang, Pin-wu Li, Jingyi Xu   +11 more
semanticscholar   +1 more source

Performance of STANDARD™ M10 SARS-CoV-2 Assay for the Diagnosis of COVID-19 from a Nasopharyngeal Swab

Infection & Chemotherapy, 2022
The STANDARD™ M10 severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) assay (M10 assay) (SD Biosensor Inc., Suwon, Korea) is a rapid, fully-automated, cartridge-type molecular diagnostic assay that detects SARS-CoV-2 RNA using primers and probes
S. Ham, Hyeonju Jeong, Jongtak Jung, E. S. Kim, K. Park, Hong-Bin Kim, J. Park, K. Song   +7 more
semanticscholar   +1 more source