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Functional role of M2 muscarinic receptors in the guinea pig ileum
Life Sciences, 1995Muscarinic agonists elicit contraction in the standard guinea pig ileum bioassay through activation of M3 muscarinic receptors that are also linked to phosphoinositide hydrolysis. Surprisingly, the most abundant muscarinic receptor in the ileum is the M2 which causes a specific inhibition of cyclic AMP accumulation elicited by the beta-adrenergic ...
F J, Ehlert, E A, Thomas
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Lack of m2 muscarinic acetylcholine receptor mRNA in rat lymphocytes
Journal of Neuroimmunology, 1994The presence of muscarinic acetylcholine receptors on lymphocytes has been demonstrated by radioligand binding experiments. Although the specific subtype(s) of muscarinic acetylcholine receptors expressed in lymphocytes is still unknown, some reports suggest the presence of the m2 subtype.
Costa, P +3 more
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Astrocytes have both M1 and M2 muscarinic receptor subtypes
Brain Research, 1986In astrocytes, carbachol evoked the turnover of membrane inositol phospholipids prelabelled with [3H]inositol, as revealed by [3H]inositol phosphate accumulation in the presence of 5 mM lithium. This effect was blocked by atropine and by pirenzepine (IC50 2.2 nM and 56 nM, respectively).
S, Murphy, B, Pearce, C, Morrow
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Expression of the Human Muscarinic Receptor Gene m2 in Dictyostelium discoideum
Nature Biotechnology, 1995We have expressed a functional human muscarinic M2 receptor, under the control of the homologous discoidin I gamma promoter, in the cellular slime mold Dictyostelium discoideum. The use of a contact site A leader peptide ensured insertion of the newly synthesized receptor protein into the plasma membrane.
G, Voith, T, Dingermann
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Studies on muscarinic M2 receptors in smooth muscle.
Proceedings of the Western Pharmacology Society, 2000Histamine after M3 receptor alkylation with 4-DAMP mustard does not serve simply as a spasmogen but facilitates visualization of the M2-mediated contraction induced by oxotremorine M. We speculate that M3 receptor activation has a similar role in untreated tissue. The facilitation appears to involve protein kinase C.
F, Mitchelson, A, Shen
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Critical Care Management of Chimeric Antigen Receptor T-Cell Therapy Recipients
Ca-A Cancer Journal for Clinicians, 2022Sandrine Valadè +2 more
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Muscarinic Cholinergic Receptor Agonist and Peripheral Antagonist for Schizophrenia
New England Journal of Medicine, 2021Stephen K Brannan +2 more
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