Results 61 to 70 of about 2,157,910 (222)

The M2 Muscarinic Receptor Mediates Contraction through Indirect Mechanisms in Mouse Urinary Bladder [PDF]

, 2005
We investigated the contractile role of M2 muscarinic receptors in mouse urinary bladder. When measured in the absence of other agents, contractions elicited to the muscarinic agonist oxotremorine-M exhibited properties consistent with that expected for ...
Taketo, Makoto M., Griffin, Michael T., Abe, Diane M., Ehlert, Frederick J., Vo, Tran H., Manabe, Toshiya, Matsui, Minoru   +6 more
core   +1 more source

Acetylcholine muscarinic M2 receptor maintains human Schwann-like adipose-derived phenotype in the absence of differentiating medium

Cell Death Discovery
Human adipose-derived stem cells (ASCs), differentiated in vitro towards Schwann-like phenotype (hdASCs), have been suggested as an alternative source of Schwann cells (SCs).
Roberta Piovesana, Alessandro Faroni, Ada Maria Tata, Adam J. Reid   +3 more
doaj   +1 more source

Intraoperative Bradycardia: Evaluating Vasovagal Events in Adult Suspension Microlaryngeal Surgery

The Laryngoscope, EarlyView.
This retrospective single‐surgeon cohort study of 190 adults undergoing suspension microlaryngoscopy found that 8.9% (17/190) developed significant intraoperative bradycardia consistent with a vasovagal response (VVR). No demographic, comorbidity, or procedural factors were significantly associated with VVR, though most affected patients required ...
Thomas Q. McClelland, Cyrus W. Abrahamson, Abbey L. Landini, Andrew P. Stein, James A. Burns   +4 more
wiley   +1 more source

Assessment of Muscarinic Receptor Subtypes in Human and Rat Lower Urinary Tract by Tissue Segment Binding Assay

Journal of Pharmacological Sciences, 2008
Muscarinic receptors in the human and rat lower urinary tract (urinary bladder detrusor muscle and mucosa, and prostate) were identified by intact tissue segment binding assays with two radioligands, and the effects of prolonged receptor activation in ...
Abu Syed Md Anisuzzaman, Shigeru Morishima, Fumiko Suzuki, Takashi Tanaka, Hatsumi Yoshiki, Zakia Sultana Sathi, Hironobu Akino, Osamu Yokoyama, Ikunobu Muramatsu   +8 more
doaj   +1 more source

Inhaled Corticosteroid Escalation After a Single Moderate Exacerbation in COPD: Differential Benefit by Exacerbation Subtype

Respirology, EarlyView.
We tested whether ICS escalation after a single moderate COPD exacerbation improved outcomes according to exacerbation treatment phenotype. ICS reduced future exacerbations only in steroid‐treated events, not antibiotic‐treated events. This study supports phenotype‐guided escalation after one moderate exacerbation, avoiding overtreatment with precise ...
Sun Hye Shin, Jihye Heo, Ji Ye Jung, Juhee Cho, Dave Singh, Danbee Kang, Hye Yun Park   +6 more
wiley   +1 more source

The (S)-(+)-enantiomer of dimethindene: A novel M2-selective muscarinic receptor antagonist

, 1995
The present study was designed to determine the in vitro affinity profile of (R)-(-)-dimethindene and (S)-(+)-dimethindene at muscarinic receptor subtypes using both functional and binding assays.
Moser, Ursula, Waelbroeck, Magali, Günter Lambrecht, Caren Hildebrandt, Hildebrandt, Caren, Otmar Pfaff, Magali Waelbroeck, Ernst Mutschler, Hou, Xue, Mutschler, Ernst, Ulrich Moser, Pfaff, Otmar, Lambrecht, Günter, Xue Hou   +13 more
core   +1 more source

A Sinonasal‐Dominant Symptom Phenotype Is Associated With COPD Exacerbations: A Multicentre Cross‐Sectional Study

Respirology, EarlyView.
We tested whether patient‐reported sinonasal symptoms are associated with COPD exacerbation history and characterize symptom‐based phenotypes. The results showed that the nasal symptom–dominant phenotype was associated with COPD exacerbation history. Sinonasal symptoms may represent a candidate treatable trait in COPD, supporting further evaluation of ...
Tasuku Yamamoto, Kazuki Hamada, Yoshikazu Yamaji, Keiko Doi, Junki Suizu, Keita Murakawa, Yoriyuki Murata, Keiji Oishi, Maki Asami‐Noyama, Nobutaka Edakuni, Tomoyuki Kakugawa, Tsunahiko Hirano, Kazuto Matsunaga   +12 more
wiley   +1 more source

Involvement of muscarinic receptors in psychomotor hyperactivity in dopamine-deficient mice

Molecular Brain, 2022
Dopamine-deficient (DD) mice exhibit psychomotor hyperactivity that might be related to a decrease in muscarinic signaling. In the present study, muscarinic acetylcholine receptor M2 (CHRM2) density decreased in the cortex in DD mice. This is significant
Masayo Fujita, Yukiko Ochiai, Yoko Hagino, Kazuto Kobayashi, Geoffrey Pavey, Brian Dean, Kazutaka Ikeda   +6 more
doaj   +1 more source

6‐Nitrodopamine as a Novel Mediator of Prostatic Smooth Muscle Function in Mouse and Human

Andrology, EarlyView.
ABSTRACT Background Epithelium‐derived catecholamines contribute to local regulation of genitourinary smooth muscle function, but the role of the endogenous 6‐nitrodopamine (6‐ND) in the prostate remains unknown. Objectives To determine whether 6‐ND is produced by mouse and human prostate and its role in smooth muscle regulation.
Alline Araujo Curiel, Fabio Henrique da Silva, Jéssica Mariana Dias, Luise Gabriela Santos Pereira, Douglas Rafael Martins Dias, Amanda Bueno Olivotti, André Almeida Schenka, Valéria Barbosa de Souza, Masato Tsutsui, Fabiola Zakia Monica, Edson Antunes, Gilberto De Nucci, Mariana G. de Oliveira   +12 more
wiley   +1 more source

Antagonist binding profile of the split chimeric muscarinic m2-trunc/m3-tail receptor

, 1998
Recent evidence suggests that G-protein-coupled receptors can behave as multiple subunit receptors, and can be split into parts, maintaining their binding ability.
MINARINI A, Barbier P., BARBIER P, Tumiatti V., Corsini G. U., BOLOGNESI ML, MAGGIO R., Colelli A., MELCHIORRE C, COLELLI A, Minarini A., CORSINI, GIOVANNI UMBERTO, Bolognesi M. L., TUMIATTI V, Melchiorre C., Pascaline Barbier, Carlo Melchiorre, Antonella Colelli, Anna Minarini, M.Laura Bolognesi, Roberto Maggio, Vincenzo Tumiatti, Giovanni U. Corsini   +22 more
core   +1 more source