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Distinct characteristics of VEXAS-causative UBA1 M41 and recurrent functional non-M41 mutations [PDF]

Leukemia
Abstract VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a severe inflammatory and hematologic disease caused by somatic mutations in UBA1 . Canonical pathogenic mutations at UBA1 p.Met41 (M41) lead to the ...
Maki Sakuma, Wencke Walter, David Beck   +2 more
exaly   +4 more sources

Induction of antiviral RNA interference by avian coronavirus IBV in PBMCs-Mφ [PDF]

Cell Communication and Signaling
Infectious bronchitis virus (IBV), a member of the gammacoronavirus family, can easily mutate, resulting in different subtypes of strains. QX and M41, two subtypes of IBV, exhibit distinct characteristics in terms of their pathogenicity and infection ...
Yaotang Wu, Jinjiao Zuo, Hongyu Jiang, Wenxin Ji, Ningna Xiong, Zhisheng Wang, Jian Lin, Qian Yang   +7 more
doaj   +2 more sources

S161: UBA1 NON-M41 VARIANTS ARE MORE AGGRESSIVE THAN UBA1 M41 VARIANTS IN THEIR HEMATOLOGICAL MANIFESTATIONS.

HemaSphere, 2023
Maki Sakuma, Constance Baer, Manja Meggendorfer, Claudia Haferlach, Wolfgang Kern, Torsten Haferlach, Wencke Walter   +6 more
doaj   +2 more sources

Immunogenicity and Protective Ability of Genotype I-Based Recombinant Japanese Encephalitis Virus (JEV) with Attenuation Mutations in E Protein against Genotype V JEV

Vaccines, 2021
Genotype V (GV) Japanese encephalitis virus (JEV) has emerged in Korea and China since 2009. Recent findings suggest that current Japanese encephalitis (JE) vaccines may reduce the ability to induce neutralizing antibodies against GV JEV compared to ...
Shigeru Tajima, Satoshi Taniguchi, Eri Nakayama, Takahiro Maeki, Takuya Inagaki, Masayuki Saijo, Chang Kweng Lim   +6 more
doaj   +1 more source

A recombinant avian infectious bronchitis virus expressing a heterologous spike gene belonging to the 4/91 serotype. [PDF]

PLoS ONE, 2011
We have shown previously that replacement of the spike (S) gene of the apathogenic IBV strain Beau-R with that from the pathogenic strain of the same serotype, M41, resulted in an apathogenic virus, BeauR-M41(S), that conferred protection against ...
Maria Armesto, Sharon Evans, David Cavanagh, Abu-Bakr Abu-Median, Sarah Keep, Paul Britton   +5 more
doaj   +1 more source

UBA1 Non-M41 Variants Are More Aggressive than UBA1 M41 Variants in Their Haematological Manifestations

EMJ Hematology, 2023
BACKGROUND AND AIMS In 2020, three somatic mutations in the X-linked gene UBA1, coding for an essential ubiquitin activating enzyme, were reported to cause VEXAS syndrome, a novel haemato-inflammatory disease that manifests with both cytopenias and autoinflammation.1 The mutations alter the start codon (M41) of the cytoplasmic isoform of UBA1 ...
Sakuma, Maki, Baer, Constance, Meggendorfer, Manja, Haferlach, Claudia, Kern, Wolfgang, Haferlach, Torsten, Walter, Wencke   +6 more
openaire   +1 more source

مطالعه ایمنی متقاطع دو واکسن کشته روغنی تهیه شده با سویه M41 و سویه ایرانی IR/773/2001 از سروتیپ 793/B در جوجه های SPF [PDF]

Archives of Razi Institute, 2008
این مطالعه برای تعیین ایمنی متقاطع بین سویه M41 از سروتیپ ماساچوست و سویه ایرانی IR/773/2001 از سروتیپ 793/B ویروس برونشیت عفونی انجام گرفت. دو گروه 20 قطعه ای جوجه SPF در سن سه هفتگی با دو واکسن کشته روغنی تجربی برونشیت عفونی تهیه شده با سویه های M41 و ...
. شوشتری, مهدی وصفی مرندی, رضا طرقی, محمدحسن بزرگمهری فرد, رضا ممیز   +4 more
doaj   +1 more source

The determinants of green finance and effect on the banking sector

Financial Internet Quarterly, 2023
This study examines the prerequisites and challenges faced by local and foreign commercial banks in Türkiye in supporting green business initiatives. This study uses backward logistic regression analysis to identify variables affecting green financing ...
Gör Yusuf, Tekin Bilgehan
doaj   +1 more source

Tubulovillous Adenoma in a Urethral Neobladder Anastomosis

Urology Case Reports, 2015
We present a case of a tubulovillous adenoma arising in a neobladder that was managed by cystoscopic resection. A 64 year-old male underwent a cystectomy with creation of an ileocolic neobladder urinary diversion for T2 urothelial carcinoma of the ...
Bradley A. Morganstern, Logan B. Greenblatt, Oksana Yaskiv, Joph Steckel   +3 more
doaj   +1 more source

Genetic and antigenic heterogeneity of GI-1/Massachusetts lineage infectious bronchitis virus variants recently isolated in China

Poultry Science, 2020
Four GI-1/Massachusetts-type (GI-1/Mass-type) infectious bronchitis virus (IBV) strains were isolated and the complete genomes of these isolates, coupled with the Mass-type live-attenuated vaccine H120 and the Mass-type pathogenic M41 strains, were ...
Jie Sheng, Mengting Ren, Zongxi Han, Junfeng Sun, Yan Zhao, Shengwang Liu   +5 more
doaj   +1 more source