Results 111 to 120 of about 170,462 (259)

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Comprehensive Profiling of Human Urinary Mercapturic Acid Conjugates Associated with Exposure to Reactive Chemical Species Using Enzymatic Deacetylation and High-Resolution Mass Spectrometry. [PDF]

Anal Chem
Chen YC, Zhuang MN, Hsu JY, Lin YC, Wu HY, Liao PC.   +5 more
europepmc   +1 more source

Neuromorphic Optical Tracking and Imaging of Randomly Moving Targets Through Dynamic Dense Scattering Media

Advanced Science, EarlyView.
Vision begins not with images but with change: the retina fires only when something moves, handing the brain a stream of spikes. A neuromorphic imaging system adopts the same strategy—an event sensor that sees like the retina, a spiking network that thinks like the brain—to track and reconstruct fully randomly moving targets through tissue (phantom ...
Ning Zhang, Arto Nurmikko
wiley   +1 more source

Ill Fate of Rectal Mucinous Adenocarcinoma: A Defect in Immunosurveillance or a Mucin Coating Effect?-The IMMUNOREACT 20 Study. [PDF]

Cancers (Basel)
Dell'Atti L, Kotsafti A, Galuppini F, Scarpa M, Salmaso R, Stepanyan A, Sbaraglia M, Saadeh LM, Tussardi G, Rosato A, Angriman I, Ruffolo C, Urso EDL, Bao QR, Negro S, Maretto I, Facci L, Rivella G, D'Angelo A, Matteazzi A, Vignotto C, Baldo A, Guzzardo V, Pellegrini V, Brignola S, Ceccon C, Stecca T, Pozza A, Massani M, De Simoni O, Pilati P, Gruppo M, Franzato B, Cataldo I, Portale G, Cipollari C, Zuin M, Laurino L, Dal Santo L, Pirozzolo G, Recordare A, Ceccarini L, Antoniutti M, Marinelli L, Brolese A, Barbareschi M, Bertalot G, Ortenzi M, Guerrieri M, Zizzo M, Fabozzi M, Guerriero S, Piccioli A, Pozza G, Godina M, Mondi I, Verdi D, Da Lio C, Noaro G, Cola R, Bordignon G, Merenda R, Becherucci G, Gavagna L, Candioli S, Tagliente G, Tedeschi U, Parini D, Salmaso B, Businello G, Cristofaro LD, Marchegiani F, Bergamo F, Lonardi S, Porzionato A, Chiminazzo V, Scognamiglio F, Bardini R, Pucciarelli S, Agostini M, Gregori D, Di Camillo B, Castagliuolo I, Spolverato G, Fassan M, Dei Tos AP, Scarpa M.   +86 more
europepmc   +1 more source

Toward Material‐Specific Peptides From in Silico Guided Peptide Engineering to Target PET in the Presence of PS

Advanced Science, EarlyView.
This work presents a computational–experimental strategy to engineer material‐binding peptides toward polymer specificity. Molecular dynamics simulations identified residues driving polystyrene binding, enabling targeted substitutions that greatly reduced polystyrene affinity while preserving PET binding.
Julian Luka, Marian Bienstein, Jonas Berger, Ulrich Schwaneberg   +3 more
wiley   +1 more source

Cardiac Macrophages Exhibit Dynamic Heterogeneity and Functional Specialization During Experimental Autoimmune Myocarditis. [PDF]

Cells
Stefanska M, Kot M, Koterba D, Zeyland J.   +3 more
europepmc   +1 more source

TiO6 as a Compensatory Structural Unit in Co‐Free, High‐Ni Layered Oxide for Durable Lithium‐Ion Batteries

Advanced Science, EarlyView.
Ti substitution stabilizes Co‐free high‐Ni layered oxides through both structural and electronic effects. TiO6 octahedra act as compensatory structural units that help interrupt cooperative Jahn–Teller distortion and suppress detrimental phase transitions, while the electron‐withdrawing inductive effect of Ti stabilizes the oxygen lattice. As a result,
Bixian Ying, Zhenjie Teng, Jun Wang, Honghong Tian, Charlotte von Petersdorff‐Campen, Rommel T. Tolla, Iuliia Mikulska, Linus Voigt, Sascha Nowak, Verena Naber, Alexander Schökel, Yuanming Liu, Michael Merz, Peter Nagel, Stefan Schuppler, Katja Frenzel, Adrian Jonas, Lena Mathies, Martin Winter, Karin Kleiner   +19 more
wiley   +1 more source

Generative artificial intelligence creates delicious, sustainable, and nutritious burgers. [PDF]

NPJ Sci Food
Tac V, Gardner CD, Kuhl E.
europepmc   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Dual‐Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti‐Inflammatory and Anti‐Fibrotic Effects

Advanced Science, EarlyView.
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang, Jinwei Li, Shan Hua, Shengming Wu, Chenlong He, Yuan Zhu, Ming Yin, Han Zhou, Huawei Liu, Chika Hasegawa, Jun Lyu, Keyue Xiao, Hua Jiang, Yilong Wang, Yuxin Qian   +14 more
wiley   +1 more source