Results 191 to 200 of about 1,138,054 (291)

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

ScRNA-seq reveals dynamic macrophage heterogeneity in chronic liver disease progression and prognostic biomarkers <i>KLF2/SPP1</i> in HCC. [PDF]

Front Immunol
Pan Q, Wang X, Li B, Cai Z, Chen S, Hu J, Yuan X, Yang J, Guo AY, Zhang Z.   +9 more
europepmc   +1 more source

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +1 more source

Subtle-seq reveals frequent ageing-associated chromosome fragmentation on nucleosome core DNA. [PDF]

Nucleic Acids Res
Matsubara R, Solberg T, Nowacki M.
europepmc   +1 more source

Novel Monoclonal Antibody Detects Small Aβ Oligomers More Sensitively Than Lecanemab in Alzheimer's Disease CSF, Serum and Culture Media

Annals of Neurology, EarlyView.
Objective Aqueously diffusible oligomers of the amyloid β‐protein (oAβ) are neurotoxic and play a role in neuronal dysfunction in Alzheimer's disease (AD). Accurate quantification of oAβ in brains and biofluids could be valuable for understanding and monitoring AD.
Yi Ran Xu, Youqi Tao, Alexandra M. Lish, Shaomin Li, Beth L. Ostaszewski, Amirah K. Anderson, Tracy Young‐Pearse, Trebor L. Lawton, Hyun‐Sik Yang, Dominic M. Walsh, Ting Yang, Dennis J. Selkoe   +11 more
wiley   +1 more source

Incorporation of Novel Synthetic Glycolipids in Liposomal Nanoparticles Affects Opsonization and In Vivo Clearance

Angewandte Chemie International Edition, EarlyView.
We prepared five glycosylated liposomal nanoparticles (G‐LNPs) to investigate the role of glycosylation and protein corona in modulating the in vivo behavior of G‐LNPs. We show that IgG and complement C3 adsorption enhanced liposomal nanoparticle clearance, with IgG promoting subsequent C3 binding.
Yingjie Yu, Xuehan Li, Yu Gao, Shijia Tao, Xiaofei Li, Lemei Zhao, Wenshuai Han, Hao Fan, Ying Qiu, Man Wang, Luying Zhou, Xiaoyan Fang, Wenhua Yang, Haiyang Zhang, Volker Mailänder, Daniel Crespy, Katharina Landfester, Shuai Jiang, Xiangzhao Mao   +18 more
wiley   +1 more source

<i>Mycobacterium avium</i> complex (MAC) elimination slopes from sputum are potential treatment response biomarkers in patients with HIV and pulmonary MAC. [PDF]

IJTLD Open
Pasipanodya JG, Nqwata L, Schmitz J, Srivastava S, Wanjalla CN, Wallis RS, Dooley KE.   +6 more
europepmc   +1 more source

Synthesis and Interfacial Behavior of Mixed Potassium N‐Lauroyl/N‐Myristoyl Glycinate Surfactants With Varying Alkyl Chain Ratios

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Biodegradable and low‐irritant amino acid–based surfactants have attracted considerable attention as environmentally friendly alternatives to conventional petroleum‐derived surfactants. In this study, a series of acyl amino acid surfactants with identical amino acid head groups but different alkyl chain lengths were synthesized via a modified ...
Toshihiro Takeshita, Tanjina Sharmin, Atsuki Nishihara, Sihyung Kim, Kazusa Mishima, Sahena Ferdosh, Agus Saptoro, Hussein Znad, Zaidul Islam Sarker, Kai Bin Liew, Mikio Ouchi, Kenji Mishima   +11 more
wiley   +1 more source

Cell death modulation dictates tissue-specific tropism of lumpy skin disease virus. [PDF]

PLoS Pathog
Wen Y, Wang T, Zhang S, Wang J, Li C, Liu C, Tang F, Dai J, Xue F.   +8 more
europepmc   +1 more source

Detecting cryptic ghost lineage introgression in four‐taxon genomic datasets

Applications in Plant Sciences, EarlyView.
Abstract Premise Hybridization and introgression are pervasive evolutionary forces that have played fundamental roles in shaping the diversity of wild and domesticated plants. Four‐taxon tests for introgression provide a reliable framework for detecting signatures of ancient introgression from genomic data, which have played an important role in ...
Evan S. Forsythe, Blaine S. Pappa, Darren A. Clavette, Devin Y. Mendoza   +3 more
wiley   +1 more source