Results 211 to 220 of about 336,654 (290)

Lost and found in translation: the value of the human imiquimod model

British Journal of Clinical Pharmacology, EarlyView.
Topical imiquimod (IMQ), a Toll‐like receptor (TLR) 7 agonist, induces transient cutaneous inflammation and is widely used in preclinical research as a ‘psoriasis‐like’ mouse model. However, accumulating evidence indicates substantial divergence between IMQ‐driven biology and human plaque psoriasis pathogenesis.
Anouk C. Meijs, Juliette A. van den Noort, Salma Assil, Naomi B. Klarenbeek, Matthijs Moerland, Tessa Niemeyer‐van der Kolk, Robert Rissmann   +6 more
wiley   +1 more source

Investigation of the Effect of Local Melatonin Application on Biomechanic Bone-Implant Connection in Titanium Implants with Different Surface Placed in Rat Tibias. [PDF]

Medicina (Kaunas)
Sökmen K, Dündar S, Ozcan EC, Tanrısever M, Istek O, Can UK.   +5 more
europepmc   +1 more source

Rocavorexant, a novel, selective orexin‐1 receptor antagonist: Safety, tolerability and pharmacokinetics in healthy adults and individuals with opioid use disorder

British Journal of Clinical Pharmacology, EarlyView.
Aims Rocavorexant (INDV‐2000), a selective orexin‐1 receptor antagonist, reduces drug self‐administration and anxiety in nonclinical studies. This Phase 1 programme evaluated the safety, pharmacokinetics and pharmacodynamics of rocavorexant in healthy volunteers and treatment‐seeking individuals with opioid use disorder (OUD).
Martin Kankam, Rana Al‐Awam, Rajinder Shiwach, Andrew S. Huhn, Malcolm A. Young, Robert L. Dobbins   +5 more
wiley   +1 more source

Sph-mediated mtDNA release and autophagy-dependent ferroptosis contribute to Staphylococcus aureus-induced mastitis. [PDF]

PLoS Pathog
Wei Y, Zhao X, Yin Z, Zhang Y, Zhai Y, Zhan B, Wang Y, He J, Wang J, Deng X, Xu L, Feng H.   +11 more
europepmc   +1 more source

Integrin-Mediated Leukocyte Recruitment in Atherosclerosis: A Mechanistic Review of β2 Integrins and VLA-4 Signaling Pathways. [PDF]

J Inflamm Res
Shahraki H, Bashash D, Mohammadi MH, Kouhpeikar H, Bahloli M, Bagheri S, Sargazi Aval O, Kargar M, Khiabani A, Yasbolaghi Sharahi J, Gheydari ME, Hamidpour M.   +11 more
europepmc   +1 more source

The ecology of inclusive education reimagined: A framework for research, policy, and practice

British Educational Research Journal, EarlyView.
Abstract Evidence suggests the educational gap between those who experience success at school and those who do not is growing. Decades of rhetoric, policy and reform have failed to deliver an inclusive form of schooling that meets the learning needs of all students and much of the blame for this is placed at the feet of schools.
Joanna Anderson
wiley   +1 more source

A Study of Epidermal Elafin Immunohistochemistry as a Diagnostic Biomarker of Acute Skin GVHD. [PDF]

Indian J Dermatol
Mahabal GD, George L, Peter DCV, Bindra MS, Thomas M, Abraham A, George B, Mathews V, Srivastava A, Pulimood S.   +9 more
europepmc   +1 more source

Affinity Peptides With pH Sensitivity for the Enrichment of CD38+ Cells

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The selective enrichment of cell populations based on surface markers is critical for the advancement of gene and cell therapies. Current antibody‐based cell isolation methods, such as fluorescence‐ and magnetic‐activated cell sorting (FACS and MACS), offer high specificity but are limited by scalability, cost, and potential adverse effects on
Gabrielle Rusch, Mickael Meyer, I. Mohamed Irfan, Carson Huber, Joseph Burclaff, Scott T. Magness, Stefano Menegatti, Michael Daniele   +7 more
wiley   +1 more source

Integration of single-cell and bulk RNA sequencing data identified an aortic dissection-enriched ANGPTL4+ macrophage subpopulation. [PDF]

Front Immunol
Li Z, Chen H, Liu X, Shao Y, Peng Y, Wu Q, Shi H, Zhang C.   +7 more
europepmc   +1 more source

Mechanism study of an articular cartilage repair material and its forward‐looking test for space medicine

BMEMat, EarlyView.
The regeneration process following dLhCG engraftment progressed through four distinct and interconnected stages. dLhCG maintained its regenerative efficacy after 6 months of cosmic exposure, supporting its potential application in space medicine.
Xu Hu, Hang Yao, Zhen Zhang, Zhonglian Wu, Huiqun Zhou, Bangheng Liu, Liang Ma, Yulei Mu, Dong‐An Wang   +8 more
wiley   +1 more source