Results 11 to 20 of about 216,238 (188)

Immunopathological outcomes are isolate dependent in chronic Mycobacterium avium complex pulmonary disease. [PDF]

Dis Model Mech
Novel treatment strategies are urgently needed to combat Mycobacterium avium complex (MAC) pulmonary disease (PD). Animal models are important for screening therapeutic strategies, but their ability to reproduce human-like immunopathology and impaired ...
Shaw TD, Lam H, Dutt TS, Pearce CM, Alshiraihi I, Obregon-Henao A, Henao-Tamayo M, Maloney Norcross SE, Meibohm B, Jackson M, Gonzalez-Juarrero M.   +10 more
europepmc   +2 more sources

C3HeB/FeJ mice with chronic <i>Mycobacterium avium</i> complex pulmonary infection exhibit impaired respiratory function but not necrotising granulomatous disease. [PDF]

Mycobacteria
Mycobacterium avium complex (MAC) is driving a global rise in pulmonary disease (MAC-PD) characterised by chronic infection, granulomatous inflammation and impaired respiratory function.
Shaw TD, Pearce CM, Lam H, Alshiraihi IM, Dutt T, Obregon-Henao A, Henao-Tamayo M, Jackson M, Gonzalez-Juarrero M.   +8 more
europepmc   +2 more sources

Phase II Feasibility Study of the Efficacy, Tolerability, and Impact on the Gut Microbiome of a Low-Residue (Fiber) Diet in Adult Patients With Mitochondrial Disease

Gastro Hep Advances, 2022
Background and Aims Gastrointestinal (GI) dysmotility is a common and debilitating clinical manifestation in patients with mitochondrial DNA (mtDNA)–related disease with no curative and few effective symptomatic therapies.
David Houghton, Y. Ng, M. Jackson, R. Stefanetti, P. Hynd, Micheál Mac Aogáin, Christopher J. Stewart, C. Lamb, A. Bright, C. Feeney, J. Newman, D. Turnbull, R. Mcfarland, A. Blain, G. Gorman   +14 more
semanticscholar   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

The rare C9 P167S risk variant for age-related macular degeneration increases polymerization of the terminal component of the complement cascade

Human Molecular Genetics, 2021
Age-related macular degeneration (AMD) is a complex neurodegenerative eye disease with behavioral and genetic etiology and is the leading cause of irreversible vision loss among elderly Caucasians.
O. McMahon, T. Hallam, S. Patel, C. Harris, A. Menny, W. M. Zelek, R. Widjajahakim, A. Java, T. Cox, N. Tzoumas, D. Steel, V. Shuttleworth, K. Smith-Jackson, V. Brocklebank, H. Griffiths, A. Cree, J. Atkinson, A. Lotery, D. Bubeck, B. Morgan, K. Marchbank, J. Seddon, D. Kavanagh   +22 more
semanticscholar   +1 more source

Isolation, phenotype, and allostimulatory activity of mouse liver dendritic cells [PDF]

, 1994
Donor liver-derived dendritic cells (DC) have recently been identified within various lymphoid and nonlymphoid tissues of organ allograft recipients, including nonimmunosuppressed mice transplanted with and permanently accepting major histocompatibility ...
Li, Y, Lu, L, Rao, AS, Starzl, TE, Subbotin, V, Thomson, AW, Woo, J   +6 more
core   +1 more source

An Observational Method to Measure the Relative Fractions of Solenoidal and Compressible Modes in Interstellar Clouds

, 2014
We introduce a new method for observationally estimating the fraction of momentum density (${\rho}{\mathbf{v}}$) power contained in solenoidal modes (for which $\nabla \cdot {\rho}{\mathbf{v}} = 0$) in molecular clouds.
Brunt, C. M., Federrath, C.
core   +1 more source

The density structure and star formation rate of non-isothermal polytropic turbulence [PDF]

, 2015
The interstellar medium of galaxies is governed by supersonic turbulence, which likely controls the star formation rate (SFR) and the initial mass function (IMF).
Banerjee, Supratik, Federrath, Christoph
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A molecular outflow evidencing star formation activity in the vicinity of the HII region G034.8-0.7 and the SNR W44 [PDF]

, 2009
This work aims at investigating the molecular gas component in the vicinity of two young stellar object (YSO) candidates identified at the border of the HII region G034.8-0.7 that is evolving within a molecular cloud shocked by the SNR W44.
Allen, Bachiller, Bessell, Caswell, Comerón, Cyganowski, Deharveng, Deharveng, Dickman, Elmegreen, Evans, Evans, Evans, Evans, Fazio, G. Dubner, Grevesse, Hanson, Helfand, Hiramatsu, Hoffman, Jackson, Johnstone, Kuchar, Leung, Lockman, M. E. Ortega, M. Rubio, Mac Low, McKee, McKee, Melioli, Milam, Moriarty-Schieven, Opik, Ortega, Radhakrishnan, Rathborne, Rathborne, Rawlings, Reach, Rieke, Robitaille, Robitaille, S. Paron, Seta, Seta, Skrutskie, van Dishoeck, van Dishoeck, van Zadelhoff, Vanhala, Werner, Wolszczan, Wu, Zavagno, Zhou   +56 more
core   +2 more sources