Results 21 to 30 of about 216,238 (188)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Modeling H2 formation in the turbulent ISM: Solenoidal versus compressive turbulent forcing [PDF]

, 2011
We present results from high-resolution three-dimensional simulations of the turbulent interstellar medium that study the influence of the nature of the turbulence on the formation of molecular hydrogen. We have examined both solenoidal (divergence-free)
Abel, Ballesteros-Paredes, Boley, Brown, Brunt, Brunt, Calder, Christoph Federrath, Colella, Elmegreen, Elmegreen, Falgarone, Federrath, Federrath, Federrath, Federrath, Ferland, Fryxell, Gillmon, Glover, Glover, Glover, Glover, Glover, Glover, Glover, Glover, Gnedin, Gnedin, Goldreich, Goldsmith, Gould, Hartmann, Heyer, Hollenbach, Hollenbach, Hollenbach, Klessen, Klessen, Krumholz, Krumholz, Larson, Lemaster, Mac Low, Mac Low, Mac Low, Mac Low, Mac Low, Martin, Milica Micic, Myers, Ossenkopf, Ostriker, Plewa, Price, Price, Pérault, Ralf S. Klessen, Roman-Duval, Scalo, Schmidt, Schneider, Sembach, Simon C. O. Glover, Solomon, Sutherland, Trevisan, Weingartner, Wolfire, Wolfire, Wong, Woodall, Zuckerman   +72 more
core   +2 more sources

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Role of transferrin, transferrin receptors, and iron in macrophage listericidal activity. [PDF]

, 1991
It is not yet known what properties distinguish macrophages which can kill facultative intracellular bacteria, such as Listeria monocytogenes, from those which cannot.
Alford, CE, Campbell, PA, King, TE
core  

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

Warm Molecular Gas Traced with CO J=7->6 in the Galaxy's Central 2 Parsecs: Dynamical Heating of the Circumnuclear Disk [PDF]

, 2005
We present an 11 arcsec resolution map of the central two parsecs of the Galaxy in the CO J =7->6 rotational transition. The CO emission shows rotation about Sgr A*, but also evidence for non-circular turbulent motion and a clumpy morphology.
A. D. Bolatto, Bradford C. M., C. M. Bradford, Ekers R. D., Flower D. R., G. J. Stacey, Gatley I., Huettemeister S., Huettemeister S., J. A. Davidson, J. M. Jackson, Koester B., M. L. Savage, Marshall J., Oort J. H., Rodriguez-Fernandez N. J., Schmid-Burgk J., Schwarz U. J., Serabyn E., T. Nikola, Wilson T. L., Wright M. C. H.   +21 more
core   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

Quire: Lightweight Provenance for Smart Phone Operating Systems [PDF]

, 2011
Smartphone apps often run with full privileges to access the network and sensitive local resources, making it difficult for remote systems to have any trust in the provenance of network connections they receive. Even within the phone, different apps with
Dietz, Michael, Pisetsky, Yuliy, Shekhar, Shashi, Shu, Anhei, Wallach, Dan S.   +4 more
core   +3 more sources

A 500 pc filamentary gas wisp in the disk of the Milky Way [PDF]

, 2013
Star formation occurs in molecular gas. In previous studies, the structure of the molecular gas has been studied in terms of molecular clouds, but has been overlooked beyond the cloud scale.
Belloche, Arnaud, Li, Guang-Xing, Menten, Karl, Wyrowski, Friedrich   +3 more
core   +2 more sources